Dysarthria (HP:0001260)
Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed.
Synonyms: Difficulty articulating speech, Dysarthric speech
Cross References: MSH:D004401, SNOMEDCT_US:8011004, UMLS:C0013362
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Amyotrophic lateral sclerosis | 4.861e-13 | 3.889e-12 | 220.61 | 6254.72 |
| 2 | Pathways of neurodegeneration | 3.368e-8 | 1.347e-7 | 62.43 | 1074.25 |
| 3 | Inositol phosphate metabolism | 0.03591 | 0.09198 | 30.74 | 102.25 |
| 4 | mRNA surveillance pathway | 0.04794 | 0.09198 | 22.79 | 69.22 |
| 5 | Spinocerebellar ataxia | 0.06926 | 0.09198 | 15.53 | 41.47 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | axo-dendritic transport (GO:0008088) | 0.002997 | 0.03670 | 444.11 | 2580.41 |
| 2 | regulation of cytoplasmic mRNA processing body assembly (GO:0010603) | 0.003495 | 0.03670 | 370.07 | 2093.27 |
| 3 | intermediate filament bundle assembly (GO:0045110) | 0.003495 | 0.03670 | 370.07 | 2093.27 |
| 4 | regulation of vesicle size (GO:0097494) | 0.003495 | 0.03670 | 370.07 | 2093.27 |
| 5 | nucleic acid transport (GO:0050657) | 0.004990 | 0.04084 | 246.68 | 1307.49 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | epidermal growth factor receptor binding (GO:0005154) | 0.01293 | 0.06939 | 88.73 | 385.85 |
| 2 | kinesin binding (GO:0019894) | 0.01441 | 0.06939 | 79.21 | 335.86 |
| 3 | miRNA binding (GO:0035198) | 0.01490 | 0.06939 | 76.48 | 321.69 |
| 4 | protein serine/threonine kinase activator activity (GO:0043539) | 0.01835 | 0.06939 | 61.59 | 246.23 |
| 5 | regulatory RNA binding (GO:0061980) | 0.01983 | 0.06939 | 56.84 | 222.86 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neurofibrillary tangle (GO:0097418) | 0.002498 | 0.02498 | 555.17 | 3326.77 |
| 2 | axon (GO:0030424) | 0.0001190 | 0.001785 | 42.19 | 381.27 |
| 3 | nuclear inner membrane (GO:0005637) | 0.01392 | 0.06958 | 82.15 | 351.18 |
| 4 | neuron projection (GO:0043005) | 0.0001086 | 0.001785 | 23.48 | 214.29 |
| 5 | cytoplasmic stress granule (GO:0010494) | 0.03204 | 0.1005 | 34.59 | 119.03 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ATXN2 | – |
| SPG11 | – |
| C9orf72 | – |
| FUS | TRETINOIN |
| MATR3 | – |
| NEFH | – |
| SETX | – |
| NEK1 | – |
| FIG4 | – |
| ALS2 | – |
