Diplopia (HP:0000651)
Diplopia is a condition in which a single object is perceived as two images, it is also known as double vision.
Synonyms: Double vision
Cross References: MSH:D004172, SNOMEDCT_US:24982008, UMLS:C0012569
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Neuroactive ligand-receptor interaction | 0.00001608 | 0.00004823 | 38.88 | 429.14 |
| 2 | Glycerophospholipid metabolism | 0.04794 | 0.05510 | 22.79 | 69.22 |
| 3 | Cholinergic synapse | 0.05510 | 0.05510 | 19.72 | 57.16 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neuromuscular process (GO:0050905) | 8.685e-8 | 0.000001307 | 535.02 | 8698.92 |
| 2 | synaptic transmission, cholinergic (GO:0007271) | 8.685e-8 | 0.000001307 | 535.02 | 8698.92 |
| 3 | neuromuscular synaptic transmission (GO:0007274) | 1.021e-7 | 0.000001307 | 503.52 | 8105.11 |
| 4 | neuronal action potential (GO:0019228) | 1.379e-7 | 0.000001471 | 450.47 | 7115.97 |
| 5 | neuromuscular junction development (GO:0007528) | 1.812e-7 | 0.000001656 | 407.53 | 6326.45 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential (GO:0099529) | 1.878e-10 | 5.821e-9 | 783.25 | 17541.62 |
| 2 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) | 8.580e-10 | 1.330e-8 | 511.90 | 10686.61 |
| 3 | transmitter-gated ion channel activity (GO:0022824) | 1.451e-9 | 1.499e-8 | 443.56 | 9026.96 |
| 4 | postsynaptic neurotransmitter receptor activity (GO:0098960) | 1.191e-7 | 8.551e-7 | 475.52 | 7581.26 |
| 5 | acetylcholine receptor activity (GO:0015464) | 1.379e-7 | 8.551e-7 | 450.47 | 7115.97 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neuromuscular junction (GO:0031594) | 4.712e-12 | 6.125e-11 | 604.76 | 15772.67 |
| 2 | acetylcholine-gated channel complex (GO:0005892) | 3.267e-8 | 1.416e-7 | 778.40 | 13417.28 |
| 3 | ion channel complex (GO:0034702) | 5.841e-7 | 0.000001898 | 267.29 | 3836.51 |
| 4 | neuron projection (GO:0043005) | 1.379e-9 | 8.967e-9 | 82.63 | 1685.72 |
| 5 | voltage-gated sodium channel complex (GO:0001518) | 0.008469 | 0.01835 | 138.71 | 661.82 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| DOK7 | – |
| MUSK | – |
| RAPSN | – |
| SCN4A | LEVOBUPIVACAINE HYDROCHLORIDE, BUPIVACAINE HYDROCHLORIDE |
| CHRNE | SUCCINYLCHOLINE CHLORIDE, PIPECURONIUM BROMIDE, MIVACURIUM CHLORIDE, METOCURINE IODIDE, DOXACURIUM CHLORIDE, VECURONIUM BROMIDE, DECAMETHONIUM BROMIDE |
| CHRNA1 | – |
| CHRNB1 | SUCCINYLCHOLINE CHLORIDE, PIPECURONIUM BROMIDE, MIVACURIUM CHLORIDE, METOCURINE IODIDE, DOXACURIUM CHLORIDE, VECURONIUM BROMIDE, DECAMETHONIUM BROMIDE |
| CHRND | SUCCINYLCHOLINE CHLORIDE, PIPECURONIUM BROMIDE, MIVACURIUM CHLORIDE, METOCURINE IODIDE, DOXACURIUM CHLORIDE, VECURONIUM BROMIDE, DECAMETHONIUM BROMIDE |
| CHAT | RIVASTIGMINE, GALANTAMINE, DONEPEZILM PILOCARPINE |
| KCNA1 | BUPIVACAINE, ISOFLURANE, DESFLURANE |
