Long COVID-Difficulty walking

Difficulty walking (HP:0002355)

Reduced ability to walk (ambulate).

Synonyms:    Difficulty in walking, Difficulty walking, Walking disability

Cross References:    MSH:D051346, SNOMEDCT_US:228158008, UMLS:C0311394

KEGG Pathway

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1Lysosome0.000029730.000118968.11709.91
2Endocytosis0.11910.21378.7418.59
3Amyotrophic lateral sclerosis0.16780.21376.0110.72
4Pathways of neurodegeneration0.21370.21374.577.06

GO: Biological Process

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1axo-dendritic transport (GO:0008088)0.0029970.02576444.112580.41
2lipid droplet formation (GO:0140042)0.0049900.02576246.681307.49
3synaptic vesicle transport (GO:0048489)0.0054880.02576222.001155.57
4post-Golgi vesicle-mediated transport (GO:0006892)0.0000099930.000311099.191142.03
5transport along microtubule (GO:0010970)0.0064820.02576184.98932.06

GO: Molecular Function

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1gap junction channel activity involved in cell communication by electrical coupling (GO:1903763)0.0029970.01065444.112580.41
2olfactory receptor binding (GO:0031849)0.0029970.01065444.112580.41
3CD4 receptor binding (GO:0042609)0.0039940.01065317.191751.86
4gap junction channel activity (GO:0005243)0.011940.0198996.46427.12
5wide pore channel activity (GO:0022829)0.012430.0198992.44405.55

GO: Cellular Component

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1endosome lumen (GO:0031904)2.326e-70.000007211372.065682.76
2trans-Golgi network membrane (GO:0032588)0.000013770.000213488.81994.11
3trans-Golgi network transport vesicle (GO:0030140)0.0074760.02575158.54776.21
4connexin complex (GO:0005922)0.010450.03084110.94506.01
5endoplasmic reticulum tubular network (GO:0071782)0.011440.03084100.85450.83

Hub genes predicted as biomarkers & predicted FDA approved drugs

Hub Genes (ranked)FDA-Approved Drugs
REEP1–
RTN2–
SPG21–
AP4E1–
AP4B1–
SPG11–
AP4S1–
KIAA0196–
BSCL2–
GJC2CARBENOXOLONE