Diarrhea (HP:0002014)
Abnormally increased frequency (usually defined as three or more) loose or watery bowel movements a day.
Synonyms: Diarrhea, Watery stool, Diarrhoea
Cross References: MSH:D003967, SNOMEDCT_US:267060006, SNOMEDCT_US:62315008, UMLS:C0011991
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Primary immunodeficiency | 3.458e-21 | 1.037e-19 | 2661.33 | 125385.00 |
| 2 | T cell receptor signaling pathway | 8.515e-10 | 1.277e-8 | 200.92 | 4196.00 |
| 3 | B cell receptor signaling pathway | 0.000007524 | 0.00006625 | 109.41 | 1290.72 |
| 4 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 0.000009993 | 0.00006625 | 99.19 | 1142.03 |
| 5 | Th1 and Th2 cell differentiation | 0.00001104 | 0.00006625 | 95.83 | 1093.80 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive thymic T cell selection (GO:0045059) | 8.995e-10 | 2.541e-8 | 4283.14 | 89214.48 |
| 2 | B cell activation (GO:0042113) | 1.020e-12 | 5.761e-11 | 378.06 | 10438.72 |
| 3 | B cell receptor signaling pathway (GO:0050853) | 1.451e-9 | 3.278e-8 | 443.56 | 9026.96 |
| 4 | antigen receptor-mediated signaling pathway (GO:0050851) | 6.059e-13 | 5.761e-11 | 259.71 | 7306.12 |
| 5 | V(D)J recombination (GO:0033151) | 0.00001235 | 0.0001163 | 555.03 | 6273.06 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | endodeoxyribonuclease activity (GO:0004520) | 0.009957 | 0.06431 | 116.79 | 538.34 |
| 2 | phosphatidylinositol-3,5-bisphosphate binding (GO:0080025) | 0.01194 | 0.06431 | 96.46 | 427.12 |
| 3 | phosphatidylinositol-3,4-bisphosphate binding (GO:0043325) | 0.01293 | 0.06431 | 88.73 | 385.85 |
| 4 | tumor necrosis factor receptor superfamily binding (GO:0032813) | 0.01392 | 0.06431 | 82.15 | 351.18 |
| 5 | phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547) | 0.01737 | 0.06431 | 65.22 | 264.33 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | T cell receptor complex (GO:0042101) | 1.975e-8 | 2.765e-7 | 951.48 | 16879.14 |
| 2 | alpha-beta T cell receptor complex (GO:0042105) | 0.000003371 | 0.00002360 | 1249.13 | 15739.23 |
| 3 | clathrin-coated endocytic vesicle (GO:0045334) | 0.0007857 | 0.002750 | 59.96 | 428.66 |
| 4 | multivesicular body (GO:0005771) | 0.02326 | 0.05427 | 48.17 | 181.19 |
| 5 | membrane raft (GO:0045121) | 0.002846 | 0.007968 | 30.79 | 180.49 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| CD19 | BLINATUMOMAB |
| CD79A | – |
| CD79B | POLATUZUMAB VEDOTIN |
| CD3E | MUROMMONAB-CD3, CATUMAXOMAB, BLINATUMOMAB |
| ZAP70 | – |
| CD3D | MUROMMONAB-CD3, CATUMAXOMAB, BLINATUMOMAB |
| RAG2 | – |
| RAG1 | – |
| CD40LG | – |
