Diabetes mellitus (HP:0000819)
A group of abnormalities characterized by hyperglycemia and glucose intolerance.
Synonyms: No synonyms found for this term.
Cross References: MSH:D003920, SNOMEDCT_US:73211009, UMLS:C0011849
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Phototransduction | 0.00008446 | 0.0003379 | 191.96 | 1800.45 |
| 2 | Retinol metabolism | 0.03349 | 0.06698 | 33.04 | 112.22 |
| 3 | Purine metabolism | 0.06267 | 0.07253 | 17.24 | 47.76 |
| 4 | Spliceosome | 0.07253 | 0.07253 | 14.80 | 38.82 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | protein localization to ciliary transition zone (GO:1904491) | 0.002997 | 0.02825 | 444.11 | 2580.41 |
| 2 | protein localization to non-motile cilium (GO:0097499) | 0.002997 | 0.02825 | 444.11 | 2580.41 |
| 3 | visual perception (GO:0007601) | 9.004e-8 | 0.000003238 | 149.07 | 2418.38 |
| 4 | sensory perception of light stimulus (GO:0050953) | 9.813e-8 | 0.000003238 | 145.78 | 2352.45 |
| 5 | regulation of rhodopsin mediated signaling pathway (GO:0022400) | 0.00006709 | 0.001476 | 217.03 | 2085.58 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | guanylate cyclase activator activity (GO:0030250) | 0.002498 | 0.03296 | 555.17 | 3326.77 |
| 2 | NADP-retinol dehydrogenase activity (GO:0052650) | 0.002997 | 0.03296 | 444.11 | 2580.41 |
| 3 | leucine zipper domain binding (GO:0043522) | 0.004990 | 0.03469 | 246.68 | 1307.49 |
| 4 | LRR domain binding (GO:0030275) | 0.006979 | 0.03469 | 170.74 | 847.70 |
| 5 | alcohol dehydrogenase (NADP+) activity (GO:0008106) | 0.008469 | 0.03469 | 138.71 | 661.82 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | spliceosomal tri-snRNP complex (GO:0097526) | 0.01589 | 0.06098 | 71.54 | 296.32 |
| 2 | U4/U6 x U5 tri-snRNP complex (GO:0046540) | 0.01589 | 0.06098 | 71.54 | 296.32 |
| 3 | U2-type precatalytic spliceosome (GO:0071005) | 0.02473 | 0.06098 | 45.22 | 167.30 |
| 4 | precatalytic spliceosome (GO:0071011) | 0.02570 | 0.06098 | 43.44 | 159.04 |
| 5 | sperm flagellum (GO:0036126) | 0.02570 | 0.06098 | 43.44 | 159.04 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CRX | – |
| GUCA1B | – |
| PRPH2 | – |
| RDH12 | – |
| RPGR | – |
| NR2E3 | – |
| TULP1 | |
| SPATA7 | – |
| PRPF3 | – |
| PDE6G | PENTOXIFYLLINE |
