Skin rash (HP:0000988)
A red eruption of the skin.
Synonyms: Rash, Skin rash
Cross References: MEDDRA:10037844, MSH:D005076, SNOMEDCT_US:112625008, SNOMEDCT_US:271807003, UMLS:C0015230
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Primary immunodeficiency | 4.712e-12 | 1.461e-10 | 604.76 | 15772.67 |
| 2 | B cell receptor signaling pathway | 2.384e-10 | 3.695e-9 | 262.03 | 5805.76 |
| 3 | NF-kappa B signaling pathway | 0.00001596 | 0.0001649 | 84.39 | 932.17 |
| 4 | Osteoclast differentiation | 0.00002904 | 0.0002251 | 68.66 | 717.28 |
| 5 | Fc epsilon RI signaling pathway | 0.0005036 | 0.003122 | 75.47 | 573.09 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of neutrophil activation (GO:1902563) | 0.000002248 | 0.00007819 | 1665.58 | 21661.60 |
| 2 | B cell receptor signaling pathway (GO:0050853) | 2.614e-12 | 1.869e-10 | 688.31 | 18357.31 |
| 3 | lymphocyte differentiation (GO:0030098) | 9.479e-13 | 9.721e-11 | 382.92 | 10601.05 |
| 4 | B cell activation (GO:0042113) | 1.020e-12 | 9.721e-11 | 378.06 | 10438.72 |
| 5 | positive regulation of B cell differentiation (GO:0045579) | 0.000008085 | 0.0002102 | 713.68 | 8368.26 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phospholipase binding (GO:0043274) | 0.00002041 | 0.0002925 | 416.21 | 4494.85 |
| 2 | non-membrane spanning protein tyrosine kinase activity (GO:0004715) | 5.841e-7 | 0.00002512 | 267.29 | 3836.51 |
| 3 | IgG binding (GO:0019864) | 0.002498 | 0.01343 | 555.17 | 3326.77 |
| 4 | non-membrane spanning protein tyrosine phosphatase activity (GO:0004726) | 0.002997 | 0.01432 | 444.11 | 2580.41 |
| 5 | phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547) | 0.0001327 | 0.001277 | 151.19 | 1349.73 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | T cell receptor complex (GO:0042101) | 0.00001481 | 0.0001925 | 499.50 | 5554.53 |
| 2 | early phagosome (GO:0032009) | 0.005985 | 0.02594 | 201.81 | 1032.95 |
| 3 | membrane raft (GO:0045121) | 0.00006115 | 0.0003975 | 53.12 | 515.34 |
| 4 | multivesicular body (GO:0005771) | 0.02326 | 0.06771 | 48.17 | 181.19 |
| 5 | cytoplasmic side of plasma membrane (GO:0009898) | 0.02717 | 0.06771 | 41.02 | 147.91 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| ZAP70 | – |
| CD79B | POLATUZUMAB VEDOTIN |
| CD79A | – |
| BTK | IBRUTINIB |
| SYK | FOSTAMATINIB |
| FCGR2B | – |
| RAG2 | – |
| RAG1 | – |
| PTPN22 | – |
