Scaling skin (HP:0040189)
Refers to the loss of the outer layer of the epidermis in large, scale-like flakes.
Synonyms: Scaling skin, Scaly skin, flaking skin, peeling skin, Desquamation
Cross References: SNOMEDCT_US:14411002, SNOMEDCT_US:271767006, UMLS:C0237849
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Terpenoid backbone biosynthesis | 0.01095 | 0.06911 | 105.66 | 476.99 |
| 2 | Hematopoietic cell lineage | 0.001064 | 0.02872 | 51.27 | 351.00 |
| 3 | Various types of N-glycan biosynthesis | 0.01933 | 0.08459 | 58.34 | 230.20 |
| 4 | Notch signaling pathway | 0.02912 | 0.08459 | 38.18 | 135.03 |
| 5 | Acute myeloid leukemia | 0.03301 | 0.08459 | 33.54 | 114.41 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | receptor transactivation (GO:0035624) | 0.002498 | 0.02820 | 555.17 | 3326.77 |
| 2 | positive regulation of smooth muscle cell differentiation (GO:0051152) | 0.002498 | 0.02820 | 555.17 | 3326.77 |
| 3 | positive regulation of leukocyte mediated immunity (GO:0002705) | 0.002498 | 0.02820 | 555.17 | 3326.77 |
| 4 | immature B cell differentiation (GO:0002327) | 0.002498 | 0.02820 | 555.17 | 3326.77 |
| 5 | regulation of dendritic cell cytokine production (GO:0002730) | 0.002498 | 0.02820 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | N-acetylgalactosamine 4-O-sulfotransferase activity (GO:0001537) | 0.002498 | 0.01806 | 555.17 | 3326.77 |
| 2 | keratin filament binding (GO:1990254) | 0.002997 | 0.01806 | 444.11 | 2580.41 |
| 3 | interleukin-6 receptor binding (GO:0005138) | 0.003495 | 0.01806 | 370.07 | 2093.27 |
| 4 | potassium channel inhibitor activity (GO:0019870) | 0.004492 | 0.01989 | 277.53 | 1500.17 |
| 5 | cysteine-type endopeptidase activity involved in execution phase of apoptosis (GO:0097200) | 0.006482 | 0.02472 | 184.98 | 932.06 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | desmosome (GO:0030057) | 0.008469 | 0.08046 | 138.71 | 661.82 |
| 2 | aggresome (GO:0016235) | 0.01737 | 0.08384 | 65.22 | 264.33 |
| 3 | cornified envelope (GO:0001533) | 0.02130 | 0.08384 | 52.77 | 203.13 |
| 4 | cell-cell junction (GO:0005911) | 0.007662 | 0.08046 | 18.33 | 89.29 |
| 5 | intrinsic component of endoplasmic reticulum membrane (GO:0031227) | 0.05889 | 0.1399 | 18.40 | 52.10 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CDSN | CARBOPLATIN |
| KIT | NILOTINIB, IMATINIB |
| IL2RA | BASILIXIMAB, DACLIZUMAB, ALDESLEUKIN, DENILEUKIN DIFTITOX, CETIRIZINE |
| ZMPSTE24 | – |
| ADAM17 | – |
| RASA1 | TRAMETINIB |
| KRT74 | – |
| CHST8 | – |
| CARD14 | – |
| CASP14 | – |
