Pruritus (HP:0000989)
Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus.
Synonyms: Itching, Skin itching, Itchy skin
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Primary immunodeficiency | 0.01884 | 0.09914 | 59.92 | 237.98 |
| 2 | ABC transporters | 0.02228 | 0.09914 | 50.37 | 191.61 |
| 3 | Sphingolipid metabolism | 0.02424 | 0.09914 | 46.16 | 171.72 |
| 4 | Arachidonic acid metabolism | 0.03009 | 0.09914 | 36.91 | 129.31 |
| 5 | Acute myeloid leukemia | 0.03301 | 0.09914 | 33.54 | 114.41 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | ceramide metabolic process (GO:0006672) | 6.794e-14 | 1.175e-11 | 610.44 | 18508.64 |
| 2 | ceramide biosynthetic process (GO:0046513) | 7.979e-12 | 6.901e-10 | 539.27 | 13780.66 |
| 3 | amide biosynthetic process (GO:0043604) | 2.433e-11 | 1.403e-9 | 424.32 | 10370.14 |
| 4 | regulation of water loss via skin (GO:0033561) | 8.685e-8 | 0.000002146 | 535.02 | 8698.92 |
| 5 | establishment of skin barrier (GO:0061436) | 8.685e-8 | 0.000002146 | 535.02 | 8698.92 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702) | 0.00003428 | 0.0009598 | 312.09 | 3208.63 |
| 2 | apolipoprotein receptor binding (GO:0034190) | 0.002997 | 0.02447 | 444.11 | 2580.41 |
| 3 | sphingosine N-acyltransferase activity (GO:0050291) | 0.003495 | 0.02447 | 370.07 | 2093.27 |
| 4 | NAD-retinol dehydrogenase activity (GO:0004745) | 0.009462 | 0.04577 | 123.28 | 574.57 |
| 5 | endodeoxyribonuclease activity (GO:0004520) | 0.009957 | 0.04577 | 116.79 | 538.34 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | lamellar body (GO:0042599) | 0.006482 | 0.05834 | 184.98 | 932.06 |
| 2 | lipid droplet (GO:0005811) | 0.03785 | 0.1414 | 29.11 | 95.32 |
| 3 | endoplasmic reticulum membrane (GO:0005789) | 0.04712 | 0.1414 | 6.79 | 20.74 |
| 4 | Golgi membrane (GO:0000139) | 0.2125 | 0.4781 | 4.60 | 7.13 |
| 5 | bounding membrane of organelle (GO:0098588) | 0.3237 | 0.5827 | 2.79 | 3.15 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ABCA12 | – |
| PNPLA1 | – |
| CYP4F22 | – |
| SDR9C7 | – |
| LIPN | – |
| CERS3 | – |
| ALOXE3 | – |
| ALOX12B | – |
| RAG1 | – |
| KIT | NILOTINIB, IMATINIB |
