Fragile nails (HP:0001808)
Nails that easily break.
Synonyms: Brittle nails
Cross References: UMLS:C1856963
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Basal transcription factors | 0.0002202 | 0.008572 | 115.97 | 976.58 |
| 2 | Nucleotide excision repair | 0.0002403 | 0.008572 | 110.81 | 923.40 |
| 3 | Long-term potentiation | 0.0004889 | 0.01151 | 76.63 | 584.21 |
| 4 | Glioma | 0.0006123 | 0.01151 | 68.21 | 504.62 |
| 5 | Arrhythmogenic right ventricular cardiomyopathy | 0.0006453 | 0.01151 | 66.38 | 487.64 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | hemidesmosome assembly (GO:0031581) | 0.00001481 | 0.001888 | 499.50 | 5554.53 |
| 2 | regulation of miRNA metabolic process (GO:2000628) | 0.002498 | 0.01370 | 555.17 | 3326.77 |
| 3 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902255) | 0.002498 | 0.01370 | 555.17 | 3326.77 |
| 4 | nucleotide-excision repair, DNA incision, 3′-to lesion (GO:0006295) | 0.00004701 | 0.001888 | 262.78 | 2618.60 |
| 5 | nucleotide-excision repair, preincision complex stabilization (GO:0006293) | 0.00004701 | 0.001888 | 262.78 | 2618.60 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neuregulin binding (GO:0038132) | 0.002498 | 0.02709 | 555.17 | 3326.77 |
| 2 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication (GO:0086083) | 0.002498 | 0.02709 | 555.17 | 3326.77 |
| 3 | calcium-dependent protein serine/threonine phosphatase activity (GO:0004723) | 0.003495 | 0.02709 | 370.07 | 2093.27 |
| 4 | 5′-3′ DNA helicase activity (GO:0043139) | 0.003495 | 0.02709 | 370.07 | 2093.27 |
| 5 | protein binding involved in heterotypic cell-cell adhesion (GO:0086080) | 0.004990 | 0.03094 | 246.68 | 1307.49 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | hemidesmosome (GO:0030056) | 0.000004719 | 0.0001746 | 999.25 | 12254.80 |
| 2 | transcription factor TFIIH core complex (GO:0000439) | 0.00001010 | 0.0001827 | 624.44 | 7182.69 |
| 3 | transcription factor TFIIH holo complex (GO:0005675) | 0.00001481 | 0.0001827 | 499.50 | 5554.53 |
| 4 | transcription factor TFIID complex (GO:0005669) | 0.0001038 | 0.0009603 | 172.08 | 1578.44 |
| 5 | intercalated disc (GO:0014704) | 0.01540 | 0.09034 | 73.93 | 308.54 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| COL17A1 | – |
| HRAS | – |
| ITGB4 | – |
| DSP | ENALAPRIL |
| EFNB1 | – |
| DLX3 | – |
| ERCC2 | OXALIPLATIN, LEUCOVORIN |
| GTF2H5 | – |
| CAMK2G | – |
| MSX1 | – |
