Alopecia (HP:0001596)
A noncongenital process of hair loss, which may progress to partial or complete baldness.
Synonyms: Hair loss
Pubmed References: PMID:14676077
Cross References: MEDDRA:10001760, MSH:D000505, SNOMEDCT_US:278040002, SNOMEDCT_US:56317004, UMLS:C0002170
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Gap junction | 3.640e-10 | 3.232e-8 | 239.84 | 5212.76 |
| 2 | GnRH signaling pathway | 4.823e-10 | 3.232e-8 | 226.16 | 4851.66 |
| 3 | Long-term depression | 1.516e-8 | 3.385e-7 | 237.31 | 4272.71 |
| 4 | GnRH secretion | 1.973e-8 | 3.762e-7 | 221.44 | 3928.66 |
| 5 | Cholinergic synapse | 1.297e-9 | 5.648e-8 | 184.09 | 3767.09 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | activation of protein kinase A activity (GO:0034199) | 0.00003048 | 0.001338 | 332.92 | 3461.84 |
| 2 | regulation of miRNA metabolic process (GO:2000628) | 0.002498 | 0.02623 | 555.17 | 3326.77 |
| 3 | negative regulation of regulatory T cell differentiation (GO:0045590) | 0.002498 | 0.02623 | 555.17 | 3326.77 |
| 4 | cellular response to glucagon stimulus (GO:0071377) | 0.00003830 | 0.001338 | 293.72 | 2987.15 |
| 5 | response to glucagon (GO:0033762) | 0.00004701 | 0.001357 | 262.78 | 2618.60 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cAMP-dependent protein kinase activity (GO:0004691) | 0.002498 | 0.01049 | 555.17 | 3326.77 |
| 2 | cyclic nucleotide-dependent protein kinase activity (GO:0004690) | 0.002997 | 0.01049 | 444.11 | 2580.41 |
| 3 | G protein-coupled serotonin receptor binding (GO:0031821) | 0.002997 | 0.01049 | 444.11 | 2580.41 |
| 4 | apolipoprotein receptor binding (GO:0034190) | 0.002997 | 0.01049 | 444.11 | 2580.41 |
| 5 | sphingosine N-acyltransferase activity (GO:0050291) | 0.003495 | 0.01112 | 370.07 | 2093.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | lamellar body (GO:0042599) | 0.006482 | 0.03025 | 184.98 | 932.06 |
| 2 | membrane raft (GO:0045121) | 0.00006115 | 0.0008561 | 53.12 | 515.34 |
| 3 | plasma membrane raft (GO:0044853) | 0.0007315 | 0.004096 | 62.22 | 449.25 |
| 4 | heterotrimeric G-protein complex (GO:0005834) | 0.01638 | 0.06553 | 69.30 | 284.93 |
| 5 | Golgi membrane (GO:0000139) | 0.00005745 | 0.0008561 | 27.81 | 271.55 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| HRAS | – |
| KRAS | PANITUMUMAB, CETUXIMAB |
| NRAS | BINIMETINIB |
| GNA11 | BINIMETINIB, CABOZANTINIB |
| PRKAR1A | – |
| PRKACA | – |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| BTK | IBRUTINIB |
| ABCA12 | – |
| CERS3 | – |
