Depression (HP:0000716)
Frequent feelings of being down, miserable, and/or hopeless; difficulty recovering from such moods; pessimism about the future; pervasive shame; feeling of inferior self-worth; thoughts of suicide and suicidal behavior.
Synonyms: Depression, Depressivity, Depressive disorder
Pubmed References: PMID:23902698
Cross References: MSH:D003866, SNOMEDCT_US:21061000119107, SNOMEDCT_US:35489007, SNOMEDCT_US:78667006, UMLS:C0011581
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | equilibrioception (GO:0050957) | 5.668e-17 | 3.287e-15 | 19989.00 | 747771.16 |
| 2 | neuromuscular process controlling balance (GO:0050885) | 1.888e-14 | 2.738e-13 | 2220.11 | 70156.55 |
| 3 | sensory perception (GO:0007600) | 4.223e-14 | 4.899e-13 | 664.83 | 20473.93 |
| 4 | sensory perception of mechanical stimulus (GO:0050954) | 2.969e-15 | 7.316e-14 | 573.51 | 19184.17 |
| 5 | sensory perception of sound (GO:0007605) | 3.784e-15 | 7.316e-14 | 552.94 | 18362.12 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | myosin binding (GO:0017022) | 0.02766 | 0.05531 | 40.27 | 144.50 |
| 2 | calcium ion binding (GO:0005509) | 0.01239 | 0.05531 | 14.19 | 62.33 |
| 3 | magnesium ion binding (GO:0000287) | 0.07066 | 0.1060 | 15.21 | 40.30 |
| 4 | metal ion binding (GO:0046872) | 0.02616 | 0.05531 | 9.45 | 34.45 |
| 5 | cadherin binding (GO:0045296) | 0.1499 | 0.1798 | 6.81 | 12.92 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | microvillus (GO:0005902) | 0.0003539 | 0.003893 | 90.61 | 720.07 |
| 2 | actin-based cell projection (GO:0098858) | 0.0007493 | 0.004121 | 61.45 | 442.20 |
| 3 | catenin complex (GO:0016342) | 0.01540 | 0.05645 | 73.93 | 308.54 |
| 4 | basement membrane (GO:0005604) | 0.02570 | 0.07068 | 43.44 | 159.04 |
| 5 | cilium (GO:0005929) | 0.1124 | 0.2473 | 9.30 | 20.33 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| GPR98 | – |
| USH1G | – |
| PCDH15 | – |
| DFNB31 | – |
| CIB2 | – |
| CDH23 | METHYLPHENIDATE |
| USH1C | – |
| CLRN1 | – |
| PDZD7 | – |
| USH2A | – |
