Delusions (HP:0000746)
A false belief that is held despite evidence to the contrary.
Synonyms: Delusions
Cross References: MSH:D003702, SNOMEDCT_US:2073000, UMLS:C0011253
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | RNA transport | 0.00009052 | 0.0004526 | 46.39 | 431.86 |
| 2 | Tyrosine metabolism | 0.01786 | 0.02976 | 63.35 | 255.00 |
| 3 | Steroid hormone biosynthesis | 0.03009 | 0.03761 | 36.91 | 129.31 |
| 4 | Herpes simplex virus 1 infection | 0.001616 | 0.004040 | 16.88 | 108.49 |
| 5 | Dopaminergic synapse | 0.06409 | 0.06409 | 16.84 | 46.28 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | oligodendrocyte development (GO:0014003) | 5.023e-8 | 0.000005626 | 658.58 | 11068.58 |
| 2 | oligodendrocyte differentiation (GO:0048709) | 1.021e-7 | 0.000005720 | 503.52 | 8105.11 |
| 3 | response to hexose (GO:0009746) | 2.058e-7 | 0.000006513 | 388.99 | 5988.96 |
| 4 | glial cell development (GO:0021782) | 2.326e-7 | 0.000006513 | 372.06 | 5682.76 |
| 5 | response to peptide (GO:1901652) | 8.148e-7 | 0.00001825 | 237.55 | 3330.49 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | translation initiation factor activity (GO:0003743) | 9.499e-7 | 0.00001805 | 225.02 | 3120.36 |
| 2 | O-methyltransferase activity (GO:0008171) | 0.004990 | 0.02370 | 246.68 | 1307.49 |
| 3 | guanyl-nucleotide exchange factor activity (GO:0005085) | 0.00004680 | 0.0004446 | 58.25 | 580.74 |
| 4 | S-adenosylmethionine-dependent methyltransferase activity (GO:0008757) | 0.02130 | 0.07830 | 52.77 | 203.13 |
| 5 | GTPase activator activity (GO:0005096) | 0.0005166 | 0.003272 | 25.30 | 191.47 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | junctional sarcoplasmic reticulum membrane (GO:0014701) | 0.004492 | 0.03593 | 277.53 | 1500.17 |
| 2 | sarcoplasmic reticulum membrane (GO:0033017) | 0.01392 | 0.05566 | 82.15 | 351.18 |
| 3 | axon (GO:0030424) | 0.09746 | 0.2542 | 10.83 | 25.22 |
| 4 | dendrite (GO:0030425) | 0.1271 | 0.2542 | 8.15 | 16.80 |
| 5 | neuron projection (GO:0043005) | 0.2457 | 0.3932 | 3.89 | 5.46 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| COMT | ENTACAPONE, OPICAPONE, REMIFENTANIL, SUFENTANIL, MODAFINIL, MORPHINE, METHADONE |
| DGCR2 | – |
| ENSP00000331681 | – |
| TBX1 | – |
| EIF2B2 | – |
| DAOA | – |
| EIF2B3 | – |
| JPH3 | – |
| EIF2B1 | – |
| DGCR14 | – |
