Constipation (HP:0002019)
Infrequent or difficult evacuation of feces.
Synonyms: Constipation, Costiveness, Dyschezia
Cross References: MSH:D003248, SNOMEDCT_US:14760008, SNOMEDCT_US:225595004, UMLS:C0009806, UMLS:C0237326
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Hedgehog signaling pathway | 0.0003416 | 0.003675 | 92.30 | 736.71 |
| 2 | Basal cell carcinoma | 0.0004323 | 0.003675 | 81.68 | 632.69 |
| 3 | Gastric cancer | 0.002386 | 0.01014 | 33.75 | 203.77 |
| 4 | Melanoma | 0.03543 | 0.1205 | 31.17 | 104.12 |
| 5 | Pathways in cancer | 0.001943 | 0.01014 | 15.80 | 98.63 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | pituitary gland development (GO:0021983) | 3.147e-9 | 2.087e-7 | 2141.36 | 41921.23 |
| 2 | positive regulation of T cell differentiation in thymus (GO:0033089) | 0.000003371 | 0.00004792 | 1249.13 | 15739.23 |
| 3 | dorsal/ventral pattern formation (GO:0009953) | 3.331e-10 | 6.629e-8 | 665.67 | 14526.48 |
| 4 | proximal/distal pattern formation (GO:0009954) | 0.000006290 | 0.00007823 | 832.67 | 9972.50 |
| 5 | dopaminergic neuron differentiation (GO:0071542) | 1.021e-7 | 0.000002033 | 503.52 | 8105.11 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | type 1 fibroblast growth factor receptor binding (GO:0005105) | 0.002498 | 0.006744 | 555.17 | 3326.77 |
| 2 | type 2 fibroblast growth factor receptor binding (GO:0005111) | 0.002498 | 0.006744 | 555.17 | 3326.77 |
| 3 | morphogen activity (GO:0016015) | 0.003495 | 0.007864 | 370.07 | 2093.27 |
| 4 | patched binding (GO:0005113) | 0.003495 | 0.007864 | 370.07 | 2093.27 |
| 5 | eukaryotic initiation factor 4E binding (GO:0008190) | 0.004990 | 0.01036 | 246.68 | 1307.49 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | nucleus (GO:0005634) | 0.001775 | 0.01775 | 8.09 | 51.21 |
| 2 | intracellular membrane-bounded organelle (GO:0043231) | 0.004410 | 0.02205 | 6.66 | 36.14 |
| 3 | membrane raft (GO:0045121) | 0.07859 | 0.2620 | 13.60 | 34.59 |
| 4 | cilium (GO:0005929) | 0.1124 | 0.2675 | 9.30 | 20.33 |
| 5 | endoplasmic reticulum lumen (GO:0005788) | 0.1337 | 0.2675 | 7.71 | 15.51 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SHH | VISMODEGIB, CAFFEINE |
| FGF8 | – |
| OTX2 | – |
| SIX3 | – |
| SOX3 | – |
| ZIC2 | – |
| GLI2 | – |
| FOXG1 | – |
| SOX10 | VEMURAFENIB |
| LHX3 | – |
