Cognitive impairment (HP:0100543)
Abnormal cognition with deficits in thinking, reasoning, or remembering.
Synonyms: Abnormality of cognition, Cognitive abnormality, Cognitive defects, Cognitive deficits, Cognitive impairment, Intellectual impairment
Comment: An individual with cognitive impairment may have trouble remembering, learning new things, concentrating, or making decisions.
Cross References: MSH:D060825, SNOMEDCT_US:386806002, UMLS:C0338656, UMLS:C0683322
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 2.854e-9 | 4.852e-8 | 369.52 | 7270.07 |
| 2 | GABAergic synapse | 7.537e-8 | 4.673e-7 | 156.12 | 2560.47 |
| 3 | Morphine addiction | 8.246e-8 | 4.673e-7 | 152.51 | 2487.64 |
| 4 | Retrograde endocannabinoid signaling | 5.840e-7 | 0.000002482 | 91.88 | 1318.78 |
| 5 | Taste transduction | 0.0008042 | 0.002278 | 59.24 | 422.16 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neuronal action potential (GO:0019228) | 2.294e-10 | 1.170e-8 | 739.70 | 16417.99 |
| 2 | membrane depolarization (GO:0051899) | 1.125e-9 | 2.869e-8 | 475.29 | 9793.38 |
| 3 | synaptic transmission, GABAergic (GO:0051932) | 0.00001235 | 0.00004197 | 555.03 | 6273.06 |
| 4 | inhibitory synapse assembly (GO:1904862) | 0.00001235 | 0.00004197 | 555.03 | 6273.06 |
| 5 | action potential (GO:0001508) | 4.648e-9 | 7.901e-8 | 324.37 | 6223.71 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | GABA-A receptor activity (GO:0004890) | 8.685e-8 | 0.000001195 | 535.02 | 8698.92 |
| 2 | benzodiazepine receptor activity (GO:0008503) | 0.00001010 | 0.00003060 | 624.44 | 7182.69 |
| 3 | voltage-gated sodium channel activity (GO:0005248) | 1.379e-7 | 0.000001195 | 450.47 | 7115.97 |
| 4 | GABA receptor activity (GO:0016917) | 1.379e-7 | 0.000001195 | 450.47 | 7115.97 |
| 5 | extracellular ligand-gated ion channel activity (GO:0005230) | 0.00001235 | 0.00003060 | 555.03 | 6273.06 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel complex (GO:0001518) | 6.098e-8 | 1.677e-7 | 611.51 | 10158.88 |
| 2 | GABA-A receptor complex (GO:1902711) | 8.685e-8 | 1.911e-7 | 535.02 | 8698.92 |
| 3 | sodium channel complex (GO:0034706) | 2.058e-7 | 3.773e-7 | 388.99 | 5988.96 |
| 4 | dendrite membrane (GO:0032590) | 3.266e-7 | 5.133e-7 | 329.08 | 4914.57 |
| 5 | neuron projection (GO:0043005) | 1.454e-11 | 1.600e-10 | 141.91 | 3541.27 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SCN2A | – |
| SCN1A | ETHOSUXIMIDE |
| KCNA2 | – |
| KCNT1 | CLOFILIUM, LOXAPINE, QUINIDINE |
| GABRG2 | – |
| KCNC1 | – |
| GABRA1 | METHOHEXITAL, BARBITAL, THIAMYLAL, ZALEPLON, ZOPICLONE, ZOLPIDEM |
| CACNA1B | ZICONOTIDE, ZICONOTIDE ACETATE, AMLODIPINE, LEVETIRACETAM |
| SCN8A | – |
| GABRD | – |
