Long COVID-Chills – LCGAR: Long COVID Gene Association Resource

A sudden sensation of feeling cold.

Synonyms: Chills

Comment: The word chills can also refer to an episode of shivering, accompanied by paleness and feeling cold.

KEGG Pathway

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	Pertussis	0.02259	0.07242	53.12	201.33
2	C-type lectin receptor signaling pathway	0.03080	0.07242	38.62	134.42
3	Yersinia infection	0.04041	0.07242	29.20	93.70
4	Apoptosis	0.04186	0.07242	28.16	89.37
5	Necroptosis	0.04677	0.07242	25.11	76.90

GO: Biological Process

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	positive regulation of protein localization to cell cortex (GO:1904778)	0.001499	0.02006	999.50	6499.56
2	positive regulation of T-helper 2 cell differentiation (GO:0045630)	0.001799	0.02006	799.56	5053.71
3	regulation of digestive system process (GO:0044058)	0.001799	0.02006	799.56	5053.71
4	regulation of type 2 immune response (GO:0002828)	0.001799	0.02006	799.56	5053.71
5	establishment of centrosome localization (GO:0051660)	0.002098	0.02006	666.27	4108.59

GO: Molecular Function

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	protein-glutamine gamma-glutamyltransferase activity (GO:0003810)	0.002697	0.01947	499.65	2955.69
2	1-phosphatidylinositol binding (GO:0005545)	0.004492	0.01947	285.43	1542.87
3	peptidoglycan binding (GO:0042834)	0.004492	0.01947	285.43	1542.87
4	ATPase binding (GO:0051117)	0.02170	0.06749	55.34	211.96
5	phosphatidylinositol binding (GO:0035091)	0.02729	0.06749	43.74	157.53

GO: Cellular Component

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	spectrin-associated cytoskeleton (GO:0014731)	8.395e-10	1.679e-8	3997.80	83546.98
2	intrinsic component of the cytoplasmic side of the plasma membrane (GO:0031235)	0.002398	0.006851	571.06	3445.29
3	cell cortex region (GO:0099738)	0.003296	0.007538	399.68	2284.21
4	cytoplasmic side of plasma membrane (GO:0009898)	0.0001106	0.0007373	188.12	1713.74
5	anchored component of external side of plasma membrane (GO:0031362)	0.005986	0.01197	210.26	1076.21

Hub genes predicted as biomarkers & predicted FDA approved drugs