Arrhythmia (HP:0011675)
Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both.
Synonyms: Abnormal heart rate, Heart rhythm disorders, Irregular heart beat, Irregular heartbeat, Arrhythmias, Cardiac arrhythmia, Cardiac arrhythmias, Cardiac rhythm disturbances
Pubmed References: PMID:19063792
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Hypertrophic cardiomyopathy | 3.494e-15 | 6.683e-14 | 559.63 | 18629.01 |
| 2 | Dilated cardiomyopathy | 5.569e-15 | 6.683e-14 | 521.75 | 17124.60 |
| 3 | Cardiac muscle contraction | 1.177e-12 | 9.416e-12 | 368.69 | 10127.07 |
| 4 | Adrenergic signaling in cardiomyocytes | 3.297e-11 | 1.978e-10 | 206.73 | 4989.52 |
| 5 | Viral myocarditis | 0.0003921 | 0.001569 | 85.91 | 673.90 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | heart contraction (GO:0060047) | 6.755e-21 | 1.067e-18 | 2419.03 | 112349.58 |
| 2 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 2.534e-18 | 1.334e-16 | 1725.20 | 69899.68 |
| 3 | cardiac muscle contraction (GO:0060048) | 2.534e-18 | 1.334e-16 | 1725.20 | 69899.68 |
| 4 | actin-myosin filament sliding (GO:0033275) | 5.941e-18 | 1.877e-16 | 1502.29 | 59587.92 |
| 5 | muscle filament sliding (GO:0030049) | 5.941e-18 | 1.877e-16 | 1502.29 | 59587.92 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | myosin heavy chain binding (GO:0032036) | 3.147e-9 | 9.440e-8 | 2141.36 | 41921.23 |
| 2 | titin binding (GO:0031432) | 0.00001750 | 0.0001750 | 454.07 | 4973.59 |
| 3 | FATZ binding (GO:0051373) | 0.002498 | 0.01070 | 555.17 | 3326.77 |
| 4 | telethonin binding (GO:0031433) | 0.003495 | 0.01311 | 370.07 | 2093.27 |
| 5 | actin monomer binding (GO:0003785) | 0.00006709 | 0.0005032 | 217.03 | 2085.58 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cardiac myofibril (GO:0097512) | 8.995e-10 | 1.484e-8 | 4283.14 | 89214.48 |
| 2 | myofibril (GO:0030016) | 7.595e-13 | 2.506e-11 | 907.64 | 25328.60 |
| 3 | muscle myosin complex (GO:0005859) | 4.082e-8 | 4.490e-7 | 713.50 | 12139.53 |
| 4 | myosin filament (GO:0032982) | 0.002997 | 0.01978 | 444.11 | 2580.41 |
| 5 | pseudopodium (GO:0031143) | 0.004492 | 0.02118 | 277.53 | 1500.17 |
Hub genes as predicted biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| MYH6 | – |
| ACTN2 | – |
| TNNI3 | – |
| MYL2 | – |
| MYBPC3 | – |
| CSRP3 | – |
| MYH7 | – |
| RYR2 | PROCAINE |
| LDB3 | – |
| MYL3 | – |
