Angina pectoris (HP:0001681)
Paroxysmal chest pain that occurs with exertion or stress and is related to myocardial ischemia.
Synonyms: No synonyms found for this term.
Cross References: MSH:D000787, SNOMEDCT_US:194828000, SNOMEDCT_US:225566008, UMLS:C0002962
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Cholesterol metabolism | 7.176e-9 | 1.579e-7 | 289.04 | 5420.31 |
| 2 | ABC transporters | 0.000001263 | 0.00001389 | 203.55 | 2764.61 |
| 3 | Riboflavin metabolism | 0.003994 | 0.01464 | 317.19 | 1751.86 |
| 4 | Fat digestion and absorption | 0.0002010 | 0.001474 | 121.64 | 1035.45 |
| 5 | Primary bile acid biosynthesis | 0.008469 | 0.02662 | 138.71 | 661.82 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of intestinal cholesterol absorption (GO:0030300) | 0.000006290 | 0.0003522 | 832.67 | 9972.50 |
| 2 | intestinal cholesterol absorption (GO:0030299) | 0.000008085 | 0.0003622 | 713.68 | 8368.26 |
| 3 | negative regulation of cholesterol transport (GO:0032375) | 0.00001235 | 0.0003950 | 555.03 | 6273.06 |
| 4 | intestinal lipid absorption (GO:0098856) | 0.00001235 | 0.0003950 | 555.03 | 6273.06 |
| 5 | nucleoside triphosphate catabolic process (GO:0009143) | 0.002498 | 0.01797 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | lipoprotein lipase activity (GO:0004465) | 0.002498 | 0.01443 | 555.17 | 3326.77 |
| 2 | phosphodiesterase I activity (GO:0004528) | 0.002498 | 0.01443 | 555.17 | 3326.77 |
| 3 | cholesterol transfer activity (GO:0120020) | 0.00003428 | 0.0004405 | 312.09 | 3208.63 |
| 4 | sterol transfer activity (GO:0120015) | 0.00003830 | 0.0004405 | 293.72 | 2987.15 |
| 5 | non-membrane spanning protein tyrosine phosphatase activity (GO:0004726) | 0.002997 | 0.01443 | 444.11 | 2580.41 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | ATP-binding cassette (ABC) transporter complex (GO:0043190) | 0.000003371 | 0.00008091 | 1249.13 | 15739.23 |
| 2 | cytoplasmic side of plasma membrane (GO:0009898) | 0.02717 | 0.1323 | 41.02 | 147.91 |
| 3 | clathrin-coated vesicle (GO:0030136) | 0.03930 | 0.1323 | 28.00 | 90.64 |
| 4 | clathrin-coated endocytic vesicle (GO:0045334) | 0.04171 | 0.1323 | 26.33 | 83.66 |
| 5 | lysosomal lumen (GO:0043202) | 0.04219 | 0.1323 | 26.02 | 82.37 |
Hub genes as predicted biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ABCG5 | – |
| ABCG8 | ATORVASTATIN |
| CYP27A1 | CHOLESTYRAMINE |
| ABCC6 | SODIUM CHLORIDE, THALIDOMIDE |
| LIPC | PENTONSAN POLYSULFATE SODIUM, FLUVASTATTIN |
| ENPP1 | – |
| PTPN22 | – |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| ZMPSTE24 | – |
| GLA | MIGALASTAT, PINDOLOL |
