Venous thrombosis (HP:0004936)
Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow.
Synonyms: Blood clot in vein
Cross References: MSH:D020246, SNOMEDCT_US:111293003, UMLS:C0042487
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Adherens junction | 0.000005053 | 0.0005053 | 125.56 | 1531.25 |
| 2 | Gastric cancer | 0.00004680 | 0.002230 | 58.25 | 580.74 |
| 3 | Hepatocellular carcinoma | 0.00006690 | 0.002230 | 51.49 | 494.97 |
| 4 | Bacterial invasion of epithelial cells | 0.0006453 | 0.01076 | 66.38 | 487.64 |
| 5 | Colorectal cancer | 0.0008042 | 0.01149 | 59.24 | 422.16 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | entry of bacterium into host cell (GO:0035635) | 0.000006290 | 0.002201 | 832.67 | 9972.50 |
| 2 | entry into host (GO:0044409) | 0.00001750 | 0.002747 | 454.07 | 4973.59 |
| 3 | positive regulation of histone H3-K4 methylation (GO:0051571) | 0.00002354 | 0.002747 | 384.17 | 4094.01 |
| 4 | cellular response to indole-3-methanol (GO:0071681) | 0.002498 | 0.02399 | 555.17 | 3326.77 |
| 5 | regulation of guanyl-nucleotide exchange factor activity (GO:1905097) | 0.002498 | 0.02399 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | I-SMAD binding (GO:0070411) | 0.00001750 | 0.0008399 | 454.07 | 4973.59 |
| 2 | G protein-coupled serotonin receptor binding (GO:0031821) | 0.002997 | 0.01798 | 444.11 | 2580.41 |
| 3 | non-membrane spanning protein tyrosine phosphatase activity (GO:0004726) | 0.002997 | 0.01798 | 444.11 | 2580.41 |
| 4 | histone methyltransferase binding (GO:1990226) | 0.005488 | 0.02927 | 222.00 | 1155.57 |
| 5 | transcription coregulator binding (GO:0001221) | 0.0003059 | 0.007341 | 97.74 | 790.95 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | beta-catenin-TCF complex (GO:1990907) | 0.006482 | 0.1037 | 184.98 | 932.06 |
| 2 | catenin complex (GO:0016342) | 0.01540 | 0.1037 | 73.93 | 308.54 |
| 3 | heterotrimeric G-protein complex (GO:0005834) | 0.01638 | 0.1037 | 69.30 | 284.93 |
| 4 | cytoplasmic side of plasma membrane (GO:0009898) | 0.02717 | 0.1132 | 41.02 | 147.91 |
| 5 | clathrin-coated vesicle (GO:0030136) | 0.03930 | 0.1132 | 28.00 | 90.64 |
Hub genes as predicted biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CTNNB1 | FLUORESCEN SODIUM |
| CASR | CINACALCET, VELCALCETIDE, CINACALCET HYDROCHLORIDE, PAMIDRONIC ACID |
| PRSS3P2 | – |
| SMAD4 | LYSINE, ALECTINIB |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| PRSS1 | – |
| CTRC | – |
| GNAQ | VERTEPORFIN |
| MET | CRIZOTINIB, OSIMERTINIB |
| PTPN22 | – |
