Tachycardia (HP:0001649)
A rapid heartrate that exceeds the range of the normal resting heartrate for age.
Synonyms: Fast heart rate, Heart racing, Racing heart, Elevated heart rate, Increased heart rate, Rapid heart beat
Cross References: MSH:D013610, SNOMEDCT_US:3424008, SNOMEDCT_US:86651002, UMLS:C0039231, UMLS:C4020868
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Adrenergic signaling in cardiomyocytes | 6.163e-7 | 0.00001664 | 90.61 | 1295.71 |
| 2 | Oxytocin signaling pathway | 0.00005163 | 0.0006971 | 56.31 | 555.83 |
| 3 | Arrhythmogenic right ventricular cardiomyopathy | 0.0006453 | 0.003940 | 66.38 | 487.64 |
| 4 | Cardiac muscle contraction | 0.0008229 | 0.003940 | 58.54 | 415.82 |
| 5 | Hypertrophic cardiomyopathy | 0.0008802 | 0.003940 | 56.54 | 397.78 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of heart rate by cardiac conduction (GO:0086091) | 4.350e-21 | 8.135e-19 | 2575.35 | 120743.21 |
| 2 | SA node cell to atrial cardiac muscle cell signaling (GO:0086018) | 8.995e-10 | 1.682e-8 | 4283.14 | 89214.48 |
| 3 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 5.833e-14 | 5.454e-12 | 1664.83 | 50731.79 |
| 4 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.147e-9 | 3.942e-8 | 2141.36 | 41921.23 |
| 5 | SA node cell action potential (GO:0086015) | 3.147e-9 | 3.942e-8 | 2141.36 | 41921.23 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006) | 8.995e-10 | 1.889e-8 | 4283.14 | 89214.48 |
| 2 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282) | 1.975e-8 | 2.765e-7 | 951.48 | 16879.14 |
| 3 | voltage-gated sodium channel activity (GO:0005248) | 2.294e-10 | 9.637e-9 | 739.70 | 16417.99 |
| 4 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008) | 4.082e-8 | 4.286e-7 | 713.50 | 12139.53 |
| 5 | sodium channel inhibitor activity (GO:0019871) | 0.000006290 | 0.00003774 | 832.67 | 9972.50 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel complex (GO:0001518) | 6.098e-8 | 0.000001890 | 611.51 | 10158.88 |
| 2 | sodium channel complex (GO:0034706) | 2.058e-7 | 0.000003190 | 388.99 | 5988.96 |
| 3 | intercalated disc (GO:0014704) | 0.0001038 | 0.0005364 | 172.08 | 1578.44 |
| 4 | junctional sarcoplasmic reticulum membrane (GO:0014701) | 0.004492 | 0.01392 | 277.53 | 1500.17 |
| 5 | voltage-gated potassium channel complex (GO:0008076) | 0.000005496 | 0.00004259 | 121.96 | 1477.11 |
Hub genes as predicted biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SCN5A | INDECAINIDE, BENZONATATE, FOSPHENYTOIN, MORICIZINE, HEXYLCAINE, PROCAINAMIDE, MEXILETINE, DISOPYRAMIDE |
| HCN4 | IVABRADINE HYDROCHLORIDE, DRONEDARONE HYDROCHLORIDE, IVABRADINE |
| KCND3 | – |
| CACNB2 | FELODIPINE, AMLODIPINE |
| KCNE3 | – |
| SCN1B | ZONISAMIDE |
| ABCC9 | NICORANDIL, PINACIDIL, TOLBUTAMIDE, GLIMEPIRIDE |
| SCN3B | ZONISAMIDE |
| RYR2 | PROCAINE |
| KCNJ5 | – |
