Pericardial effusion (HP:0001698)
Accumulation of fluid within the pericardium.
Synonyms: Fluid around heart, Pericardial effusions
Cross References: Fyler:1940, MSH:D010490, SNOMEDCT_US:373945007, UMLS:C0031039
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Riboflavin metabolism | 0.003994 | 0.06789 | 317.19 | 1751.86 |
| 2 | ABC transporters | 0.0002202 | 0.007487 | 115.97 | 976.58 |
| 3 | Pantothenate and CoA biosynthesis | 0.01045 | 0.07158 | 110.94 | 506.01 |
| 4 | Collecting duct acid secretion | 0.01342 | 0.07158 | 85.32 | 367.79 |
| 5 | Asthma | 0.01540 | 0.07158 | 73.93 | 308.54 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of vascular endothelial growth factor signaling pathway (GO:1900748) | 0.000003371 | 0.0007248 | 1249.13 | 15739.23 |
| 2 | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (GO:0032831) | 0.002498 | 0.02728 | 555.17 | 3326.77 |
| 3 | nucleoside triphosphate catabolic process (GO:0009143) | 0.002498 | 0.02728 | 555.17 | 3326.77 |
| 4 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 0.00003830 | 0.004117 | 293.72 | 2987.15 |
| 5 | cellular trivalent inorganic anion homeostasis (GO:0072502) | 0.002997 | 0.02728 | 444.11 | 2580.41 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | anion:sodium symporter activity (GO:0015373) | 0.002498 | 0.01746 | 555.17 | 3326.77 |
| 2 | phosphodiesterase I activity (GO:0004528) | 0.002498 | 0.01746 | 555.17 | 3326.77 |
| 3 | ATP-activated inward rectifier potassium channel activity (GO:0015272) | 0.002997 | 0.01746 | 444.11 | 2580.41 |
| 4 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) | 0.003495 | 0.01746 | 370.07 | 2093.27 |
| 5 | ABC-type glutathione S-conjugate transporter activity (GO:0015431) | 0.003495 | 0.01746 | 370.07 | 2093.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cardiac myofibril (GO:0097512) | 0.002498 | 0.04621 | 555.17 | 3326.77 |
| 2 | MHC class II protein complex (GO:0042613) | 0.006482 | 0.05149 | 184.98 | 932.06 |
| 3 | cation-transporting ATPase complex (GO:0090533) | 0.007973 | 0.05149 | 147.96 | 714.91 |
| 4 | MHC protein complex (GO:0042611) | 0.009957 | 0.05149 | 116.79 | 538.34 |
| 5 | myofibril (GO:0030016) | 0.01342 | 0.05149 | 85.32 | 367.79 |
Hub genes as predicted biomarkers & FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| MYBPC3 | – |
| CCBE1 | – |
| HLA-DRB1 | CLAVULANIC ACID, PITAVASTATIN |
| CLCNKB | – |
| ABCC9 | NICORANDIL, PINACIDIL, TOLBUTAMIDE, GLIMEPIRIDE |
| ADAMTS3 | – |
| PTPN14 | – |
| ENPP1 | – |
| SLC12A3 | POLYTHIAZIDE, BENDROFLUMETHIAZIDE, QUINETHAZONE, METOLAZONE, BENZTHIAZIDE, TRICHLORMETHIAZIDE, CHLOROTHIZIDE, CHLOROTHIAZIDE SODIUM, INDAPAMIDE, HYDROCHL OROTHIAZIDE |
| ABCC6 | SODIUM CHLORIDE, THALIDOMIDE |
