Abnormal heart rate variability (HP:0031860)
Any abnormality in the variability of the time interval between successive heartbeats.
Pubmed References: PMID:8598068
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Hedgehog signaling pathway | 0.000002460 | 0.00005167 | 161.22 | 2082.13 |
| 2 | Basal cell carcinoma | 0.0004323 | 0.004540 | 81.68 | 632.69 |
| 3 | TGF-beta signaling pathway | 0.0009597 | 0.006718 | 54.07 | 375.73 |
| 4 | Gastric cancer | 0.002386 | 0.01002 | 33.75 | 203.77 |
| 5 | Melanoma | 0.03543 | 0.1240 | 31.17 | 104.12 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry (GO:1900175) | 0.000002248 | 0.00009367 | 1665.58 | 21661.60 |
| 2 | positive regulation of T cell differentiation in thymus (GO:0033089) | 0.000003371 | 0.0001204 | 1249.13 | 15739.23 |
| 3 | dorsal/ventral pattern formation (GO:0009953) | 3.331e-10 | 8.328e-8 | 665.67 | 14526.48 |
| 4 | pituitary gland development (GO:0021983) | 0.000004719 | 0.0001263 | 999.25 | 12254.80 |
| 5 | proximal/distal pattern formation (GO:0009954) | 0.000006290 | 0.0001430 | 832.67 | 9972.50 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | morphogen activity (GO:0016015) | 0.000004719 | 0.0001321 | 999.25 | 12254.80 |
| 2 | type 1 fibroblast growth factor receptor binding (GO:0005105) | 0.002498 | 0.006994 | 555.17 | 3326.77 |
| 3 | type 2 fibroblast growth factor receptor binding (GO:0005111) | 0.002498 | 0.006994 | 555.17 | 3326.77 |
| 4 | patched binding (GO:0005113) | 0.003495 | 0.008897 | 370.07 | 2093.27 |
| 5 | activin receptor binding (GO:0070697) | 0.004990 | 0.01164 | 246.68 | 1307.49 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | condensed nuclear chromosome (GO:0000794) | 0.009957 | 0.1025 | 116.79 | 538.34 |
| 2 | condensed chromosome (GO:0000793) | 0.02668 | 0.1245 | 41.80 | 151.46 |
| 3 | nuclear chromosome (GO:0000228) | 0.04074 | 0.1426 | 26.98 | 86.34 |
| 4 | collagen-containing extracellular matrix (GO:0062023) | 0.01465 | 0.1025 | 12.97 | 54.78 |
| 5 | chromosome (GO:0005694) | 0.07720 | 0.1834 | 13.86 | 35.50 |
Hub genes as predicted biomarkers & FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| ZIC2 | – |
| SIX3 | – |
| SHH | VISMODEGIB, CAFFEINE |
| GLI2 | – |
| CDON | – |
| FGF8 | – |
| NODAL | – |
| TGIF1 | – |
| PHOX2B | – |
| SMC1A | – |
