Bradykinesia (HP:0002067)
Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement).
Synonyms: Slowness of movements, Slow movements
Cross References: MSH:D018476, SNOMEDCT_US:399317006, UMLS:C0233565
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 8.806e-7 | 0.00002466 | 231.12 | 3222.36 |
| 2 | Taste transduction | 0.000009013 | 0.00007479 | 102.79 | 1194.10 |
| 3 | GABAergic synapse | 0.000009993 | 0.00007479 | 99.19 | 1142.03 |
| 4 | Morphine addiction | 0.00001068 | 0.00007479 | 96.93 | 1109.48 |
| 5 | Retrograde endocannabinoid signaling | 0.00004587 | 0.0002569 | 58.66 | 585.95 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | membrane depolarization during action potential (GO:0086010) | 4.685e-10 | 2.460e-8 | 605.09 | 12998.28 |
| 2 | membrane depolarization (GO:0051899) | 1.125e-9 | 3.938e-8 | 475.29 | 9793.38 |
| 3 | neuronal action potential (GO:0019228) | 1.379e-7 | 0.000002414 | 450.47 | 7115.97 |
| 4 | synaptic transmission, GABAergic (GO:0051932) | 0.00001235 | 0.00009259 | 555.03 | 6273.06 |
| 5 | inhibitory synapse assembly (GO:1904862) | 0.00001235 | 0.00009259 | 555.03 | 6273.06 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel activity (GO:0005248) | 2.294e-10 | 7.801e-9 | 739.70 | 16417.99 |
| 2 | GABA-A receptor activity (GO:0004890) | 8.685e-8 | 9.843e-7 | 535.02 | 8698.92 |
| 3 | sodium channel activity (GO:0005272) | 2.307e-9 | 3.921e-8 | 391.29 | 7781.87 |
| 4 | benzodiazepine receptor activity (GO:0008503) | 0.00001010 | 0.00004907 | 624.44 | 7182.69 |
| 5 | GABA receptor activity (GO:0016917) | 1.379e-7 | 0.000001172 | 450.47 | 7115.97 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | voltage-gated sodium channel complex (GO:0001518) | 7.474e-11 | 2.093e-9 | 1024.46 | 23887.38 |
| 2 | sodium channel complex (GO:0034706) | 3.965e-10 | 4.837e-9 | 633.94 | 13723.68 |
| 3 | GABA-A receptor complex (GO:1902711) | 8.685e-8 | 4.863e-7 | 535.02 | 8698.92 |
| 4 | integral component of plasma membrane (GO:0005887) | 5.182e-10 | 4.837e-9 | 115.51 | 2469.57 |
| 5 | neuron to neuron synapse (GO:0098984) | 0.003994 | 0.01398 | 317.19 | 1751.86 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SCN1A | ETHOSUXIMIDE |
| GABRG2 | – |
| SCN2A | – |
| GABRA1 | METHOHEXITAL, BARBITAL, THIAMYLAL, ZALEPLON, ZOPICLONE, ZOLPIDEM |
| SCN1B | ZONISAMIDE |
| GABRD | – |
| ATP1A3 | ACETYLDIGITOXIN, DESLANOSIDE, DIGITOXIN |
| PCDH19 | – |
| SCN9A | – |
| ATXN3 | – |
