Bone pain (HP:0002653)
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.
Synonyms: Bone pain
Cross References: SNOMEDCT_US:12584003, UMLS:C0151825
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Parathyroid hormone synthesis, secretion and action | 9.380e-10 | 4.033e-8 | 196.92 | 4093.45 |
| 2 | Mineral absorption | 0.000003034 | 0.00006524 | 149.87 | 1904.21 |
| 3 | Riboflavin metabolism | 0.003994 | 0.02862 | 317.19 | 1751.86 |
| 4 | Prolactin signaling pathway | 0.0005336 | 0.005736 | 73.24 | 551.94 |
| 5 | Pantothenate and CoA biosynthesis | 0.01045 | 0.06421 | 110.94 | 506.01 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cellular trivalent inorganic anion homeostasis (GO:0072502) | 1.799e-9 | 1.103e-7 | 2855.29 | 57494.92 |
| 2 | cellular phosphate ion homeostasis (GO:0030643) | 1.799e-9 | 1.103e-7 | 2855.29 | 57494.92 |
| 3 | phosphate ion homeostasis (GO:0055062) | 6.605e-12 | 1.215e-9 | 2220.44 | 57161.21 |
| 4 | trivalent inorganic anion homeostasis (GO:0072506) | 0.000002248 | 0.00008273 | 1665.58 | 21661.60 |
| 5 | negative regulation of bone mineralization (GO:0030502) | 0.00002041 | 0.0006188 | 416.21 | 4494.85 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | sodium:phosphate symporter activity (GO:0005436) | 0.00001235 | 0.0005679 | 555.03 | 6273.06 |
| 2 | solute:proton antiporter activity (GO:0015299) | 0.002498 | 0.02087 | 555.17 | 3326.77 |
| 3 | type 1 fibroblast growth factor receptor binding (GO:0005105) | 0.002498 | 0.02087 | 555.17 | 3326.77 |
| 4 | phosphodiesterase I activity (GO:0004528) | 0.002498 | 0.02087 | 555.17 | 3326.77 |
| 5 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) | 0.003495 | 0.02087 | 370.07 | 2093.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | brush border membrane (GO:0031526) | 0.01835 | 0.05811 | 61.59 | 246.23 |
| 2 | vesicle (GO:0031982) | 0.005389 | 0.04011 | 22.06 | 115.23 |
| 3 | integral component of plasma membrane (GO:0005887) | 0.0003728 | 0.007084 | 12.80 | 101.01 |
| 4 | lytic vacuole membrane (GO:0098852) | 0.007445 | 0.04011 | 18.61 | 91.19 |
| 5 | endoplasmic reticulum lumen (GO:0005788) | 0.008444 | 0.04011 | 17.41 | 83.12 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| PHEX | CALCITRIOL |
| FGF23 | BUROSUMAB |
| SLC34A3 | – |
| DMP1 | – |
| SLC34A1 | – |
| VDR | CALCIPOTRIOL, CALCIUM, DIHYDROTACHYSTEROL |
| ENPP1 | – |
| TNFSF11 | DENOSUMAB, LENALIDOMIDE, ANASTROZOLE, LETROZOLE |
| CLCN5 | – |
| STAT5B | TOFACITINIB, DASATINIB, EPOETIN ALFA |
