Back pain (HP:0003418)
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back.
Synonyms: Back pain
Cross References: MSH:D001416, SNOMEDCT_US:161891005, UMLS:C0004604
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Chronic myeloid leukemia | 0.000006207 | 0.0001552 | 116.93 | 1401.96 |
| 2 | Pancreatic cancer | 0.000006207 | 0.0001552 | 116.93 | 1401.96 |
| 3 | Gastric cancer | 6.000e-7 | 0.00006061 | 91.24 | 1307.15 |
| 4 | Aldosterone-regulated sodium reabsorption | 0.0001485 | 0.001326 | 142.54 | 1256.48 |
| 5 | Colorectal cancer | 0.000009013 | 0.0001878 | 102.79 | 1194.10 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of histone H3-K9 acetylation (GO:2000617) | 0.000002248 | 0.0007621 | 1665.58 | 21661.60 |
| 2 | regulation of histone H3-K9 acetylation (GO:2000615) | 0.00001235 | 0.002093 | 555.03 | 6273.06 |
| 3 | positive regulation of histone H3-K4 methylation (GO:0051571) | 0.00002354 | 0.002660 | 384.17 | 4094.01 |
| 4 | cellular response to indole-3-methanol (GO:0071681) | 0.002498 | 0.03309 | 555.17 | 3326.77 |
| 5 | establishment of protein localization to telomere (GO:0070200) | 0.002498 | 0.03309 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | transcription coactivator binding (GO:0001223) | 0.00004255 | 0.001127 | 277.39 | 2791.90 |
| 2 | RNA-directed DNA polymerase activity (GO:0003964) | 0.002997 | 0.02269 | 444.11 | 2580.41 |
| 3 | telomerase activity (GO:0003720) | 0.002997 | 0.02269 | 444.11 | 2580.41 |
| 4 | 1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005) | 0.003495 | 0.02316 | 370.07 | 2093.27 |
| 5 | potassium channel inhibitor activity (GO:0019870) | 0.004492 | 0.02404 | 277.53 | 1500.17 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phosphatidylinositol 3-kinase complex, class I (GO:0097651) | 0.002498 | 0.04492 | 555.17 | 3326.77 |
| 2 | transferase complex, transferring phosphorus-containing groups (GO:0061695) | 0.004492 | 0.04492 | 277.53 | 1500.17 |
| 3 | intercalated disc (GO:0014704) | 0.01540 | 0.09303 | 73.93 | 308.54 |
| 4 | cell-cell contact zone (GO:0044291) | 0.02326 | 0.09303 | 48.17 | 181.19 |
| 5 | mitochondrial outer membrane (GO:0005741) | 0.06126 | 0.1930 | 17.66 | 49.31 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| PIK3CA | – |
| KRAS | PANITUMUMAB, CETUXIMAB |
| SMAD4 | LYSINE, ALECTINIB |
| BRCA1 | – |
| PALB2 | OLAPARIB, MITOMYCIN |
| TERT | OMACETAXINE MEPESUCCINATE |
| TBX6 | – |
| ALDH18A1 | – |
| RASA1 | TRAMETINIB |
| MESP2 | – |
