Babinski sign (HP:0003487)
Upturning of the big toe (and sometimes fanning of the other toes) in response to stimulation of the sole of the foot. If the Babinski sign is present it can indicate damage to the corticospinal tract.
Synonyms: Extensor plantar reflexes, Extensor plantar response, Extensor plantar responses, Positive Babinski sign
Comment: A positive Babinski sign can indicate damage to the corticospinal tract.
Cross References: SNOMEDCT_US:246586009, SNOMEDCT_US:366575004, UMLS:C0034935
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Lysosome | 0.00002973 | 0.0001189 | 68.11 | 709.91 |
| 2 | Endocytosis | 0.1191 | 0.2137 | 8.74 | 18.59 |
| 3 | Amyotrophic lateral sclerosis | 0.1678 | 0.2137 | 6.01 | 10.72 |
| 4 | Pathways of neurodegeneration | 0.2137 | 0.2137 | 4.57 | 7.06 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | axo-dendritic transport (GO:0008088) | 0.002997 | 0.02686 | 444.11 | 2580.41 |
| 2 | membrane fission (GO:0090148) | 0.003495 | 0.02686 | 370.07 | 2093.27 |
| 3 | protein hexamerization (GO:0034214) | 0.004492 | 0.02686 | 277.53 | 1500.17 |
| 4 | synaptic vesicle transport (GO:0048489) | 0.005488 | 0.02686 | 222.00 | 1155.57 |
| 5 | axonal transport of mitochondrion (GO:0019896) | 0.005488 | 0.02686 | 222.00 | 1155.57 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | olfactory receptor binding (GO:0031849) | 0.002997 | 0.01323 | 444.11 | 2580.41 |
| 2 | CD4 receptor binding (GO:0042609) | 0.003994 | 0.01323 | 317.19 | 1751.86 |
| 3 | alpha-tubulin binding (GO:0043014) | 0.01540 | 0.01854 | 73.93 | 308.54 |
| 4 | beta-tubulin binding (GO:0048487) | 0.01589 | 0.01854 | 71.54 | 296.32 |
| 5 | microtubule binding (GO:0008017) | 0.005670 | 0.01323 | 21.48 | 111.10 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | endosome lumen (GO:0031904) | 2.326e-7 | 0.000007211 | 372.06 | 5682.76 |
| 2 | trans-Golgi network membrane (GO:0032588) | 0.00001377 | 0.0002134 | 88.81 | 994.11 |
| 3 | trans-Golgi network transport vesicle (GO:0030140) | 0.007476 | 0.03863 | 158.54 | 776.21 |
| 4 | endoplasmic reticulum tubular network (GO:0071782) | 0.01144 | 0.05068 | 100.85 | 450.83 |
| 5 | trans-Golgi network (GO:0005802) | 0.0001901 | 0.001964 | 35.87 | 307.37 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| REEP1 | – |
| RTN2 | – |
| SPG21 | – |
| SPG11 | – |
| KIAA0196 | – |
| NIPA1 | – |
| AP4B1 | – |
| AP4S1 | – |
| AP4E1 | – |
| SPAST | – |
