Long COVID-Autoimmunity-Antinuclear antibody positivity
May 19, 2022HPO term: Antinuclear antibody positivity
Definition: The presence of autoantibodies in the serum that react against nuclei or nuclear components.
Synonyms: Antinuclear antibody positive; Serum antinuclear antibody; Antinuclear antibodies; Elevated antinuclear antibody
Plain-language label: Antinuclear antibody
Plain-language definition: An autoantibody is a kind of antibody that is directed against a substance made by one’s own body (usually, antibodies are directed against external agents such as bacteria). This term refers to autoantibodies directed against components of the nucleus of the cell
Gene-association
Gene Ontology
KEGG – Pathway
Hub genes & FDA repurposed drugs
| CTLA4 | IPILIMUMAB, ABATACEPT |
| IL2RA | BASILIXIMAB, DACLIZUMAB, ALDESLEUKIN, DENILEUKIN DIFTITOX, CETIRIZINE |
| FAS | TENIPOSIDE |
| FASLG | – |
| FCGR2B | – |
| RIPK1 | – |
| IL12RB1 | – |
| MS4A1 | TOSITUMOMAB, OFATUMUMAB, OBINUTUZUMAB, OCRELIZUMAB, IBRITUMOMAB TIUXETAN, YTTRIUM Y 90 IBRITUMOMAB TIUXETAN, RITUXIMAB |
| PTPN22 | – |
| ACP5 | FILGRASTIM, ALTEPLASE |
