Arthritis (HP:0001369)
Inflammation of a joint.
Synonyms: Arthritis, Joint inflammation
Cross References: MSH:D001168, SNOMEDCT_US:3723001, UMLS:C0003864
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | B cell receptor signaling pathway | 5.146e-8 | 0.000001492 | 172.41 | 2893.43 |
| 2 | Osteoclast differentiation | 0.00002904 | 0.0004211 | 68.66 | 717.28 |
| 3 | Fc epsilon RI signaling pathway | 0.0005036 | 0.004251 | 75.47 | 573.09 |
| 4 | ECM-receptor interaction | 0.0008418 | 0.004251 | 57.86 | 409.65 |
| 5 | Fc gamma R-mediated phagocytosis | 0.001021 | 0.004251 | 52.36 | 360.55 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of neutrophil activation (GO:1902563) | 0.000002248 | 0.0001323 | 1665.58 | 21661.60 |
| 2 | B cell receptor signaling pathway (GO:0050853) | 1.451e-9 | 3.568e-7 | 443.56 | 9026.96 |
| 3 | positive regulation of B cell differentiation (GO:0045579) | 0.000008085 | 0.0003315 | 713.68 | 8368.26 |
| 4 | negative regulation of B cell proliferation (GO:0030889) | 0.00001481 | 0.0004554 | 499.50 | 5554.53 |
| 5 | negative regulation of dendritic cell differentiation (GO:2001199) | 0.002498 | 0.01707 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phospholipase binding (GO:0043274) | 0.00002041 | 0.0004286 | 416.21 | 4494.85 |
| 2 | IgG binding (GO:0019864) | 0.002498 | 0.01259 | 555.17 | 3326.77 |
| 3 | MHC class II protein binding (GO:0042289) | 0.002997 | 0.01259 | 444.11 | 2580.41 |
| 4 | non-membrane spanning protein tyrosine kinase activity (GO:0004715) | 0.0001327 | 0.001393 | 151.19 | 1349.73 |
| 5 | phospholipase activator activity (GO:0016004) | 0.005488 | 0.01571 | 222.00 | 1155.57 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | early phagosome (GO:0032009) | 0.005985 | 0.02155 | 201.81 | 1032.95 |
| 2 | T cell receptor complex (GO:0042101) | 0.005985 | 0.02155 | 201.81 | 1032.95 |
| 3 | collagen-containing extracellular matrix (GO:0062023) | 5.619e-7 | 0.00001011 | 52.31 | 752.79 |
| 4 | endoplasmic reticulum lumen (GO:0005788) | 0.0003190 | 0.002871 | 29.95 | 241.12 |
| 5 | basement membrane (GO:0005604) | 0.02570 | 0.07335 | 43.44 | 159.04 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| COL2A1 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| SYK | FOSTAMATINIB |
| BTK | IBRUTINIB |
| CD79B | POLATUZUMAB VEDOTIN |
| ACAN | – |
| FCGR2B | – |
| COL9A3 | – |
| MATN3 | – |
| ASPN | – |
