Arthralgia (HP:0002829)
Joint pain.
Synonyms: Joint pain, Joint pains, Arthralgias, Arthritic pain
Comment: Arthralgia is distinct from Arthritis, which is not a symptom but a diagnosis with articular inflammation or signs of osteoarthritis.
Cross References: MSH:D018771, SNOMEDCT_US:57676002, UMLS:C0003862
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Primary immunodeficiency | 7.523e-7 | 0.00001843 | 244.35 | 3445.31 |
| 2 | Hematopoietic cell lineage | 1.159e-7 | 0.000005680 | 139.61 | 2229.69 |
| 3 | Intestinal immune network for IgA production | 0.0002507 | 0.002457 | 108.39 | 898.70 |
| 4 | Autoimmune thyroid disease | 0.0003059 | 0.002498 | 97.74 | 790.95 |
| 5 | Cytokine-cytokine receptor interaction | 0.000009081 | 0.0001483 | 45.13 | 523.92 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | negative regulation of B cell proliferation (GO:0030889) | 0.00001481 | 0.0004628 | 499.50 | 5554.53 |
| 2 | B cell proliferation (GO:0042100) | 4.430e-7 | 0.00003339 | 294.99 | 4315.59 |
| 3 | B cell receptor signaling pathway (GO:0050853) | 5.342e-7 | 0.00003339 | 275.93 | 3985.12 |
| 4 | embryonic skeletal joint morphogenesis (GO:0060272) | 0.002498 | 0.01559 | 555.17 | 3326.77 |
| 5 | negative regulation of regulatory T cell differentiation (GO:0045590) | 0.002498 | 0.01559 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | MHC class II protein binding (GO:0042289) | 0.002997 | 0.01317 | 444.11 | 2580.41 |
| 2 | tumor necrosis factor-activated receptor activity (GO:0005031) | 0.004492 | 0.01317 | 277.53 | 1500.17 |
| 3 | platelet-derived growth factor binding (GO:0048407) | 0.005488 | 0.01317 | 222.00 | 1155.57 |
| 4 | complement receptor activity (GO:0004875) | 0.005488 | 0.01317 | 222.00 | 1155.57 |
| 5 | death receptor activity (GO:0005035) | 0.005985 | 0.01317 | 201.81 | 1032.95 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | CD95 death-inducing signaling complex (GO:0031265) | 0.002498 | 0.01125 | 555.17 | 3326.77 |
| 2 | death-inducing signaling complex (GO:0031264) | 0.003994 | 0.01125 | 317.19 | 1751.86 |
| 3 | membrane raft (GO:0045121) | 0.002846 | 0.01125 | 30.79 | 180.49 |
| 4 | clathrin-coated vesicle (GO:0030136) | 0.03930 | 0.05097 | 28.00 | 90.64 |
| 5 | plasma membrane raft (GO:0044853) | 0.04026 | 0.05097 | 27.31 | 87.73 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| CD19 | BLINATUMOMAB |
| CR2 | PROGESTERONE |
| TNFRSF13B | – |
| TNFRSF13C | – |
| FAS | TENIPOSIDE |
| MS4A1 | TOSITUMOMAB, OFATUMUMAB, OBINUTUZUMAB, OCRELIZUMAB, IBRITUMOMAB TIUXETAN, YTTRIUM Y 90 IBRITUMOMAB TIUXETAN, RITUXIMAB |
| IL2RA | BASILIXIMAB, DACLIZUMAB, ALDESLEUKIN, DENILEUKIN DIFTITOX, CETIRIZINE |
| COL2A1 | COLLAGENASE CLOSTRIDIUM HISTOLYTICUM, OCRIPLASMIN |
| COL10A1 | – |
