Anosmia (HP:0000458)
An inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell.
Synonyms: Lost smell, Loss of smell
Cross References: MSH:D000857, SNOMEDCT_US:44169009, UMLS:C0003126
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | GnRH secretion | 0.000003690 | 0.00005167 | 140.02 | 1751.57 |
| 2 | Neuroactive ligand-receptor interaction | 0.00001608 | 0.0001125 | 38.88 | 429.14 |
| 3 | Melanoma | 0.03543 | 0.1448 | 31.17 | 104.12 |
| 4 | GnRH signaling pathway | 0.04555 | 0.1448 | 24.03 | 74.23 |
| 5 | Breast cancer | 0.07113 | 0.1448 | 15.10 | 39.92 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neuroepithelial cell differentiation (GO:0060563) | 0.002997 | 0.03670 | 444.11 | 2580.41 |
| 2 | negative regulation of striated muscle tissue development (GO:0045843) | 0.003495 | 0.03670 | 370.07 | 2093.27 |
| 3 | regulation of growth hormone secretion (GO:0060123) | 0.003495 | 0.03670 | 370.07 | 2093.27 |
| 4 | nose development (GO:0043584) | 0.003495 | 0.03670 | 370.07 | 2093.27 |
| 5 | limb development (GO:0060173) | 0.00009070 | 0.007618 | 184.84 | 1720.52 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | type 1 fibroblast growth factor receptor binding (GO:0005105) | 0.002498 | 0.02123 | 555.17 | 3326.77 |
| 2 | type 2 fibroblast growth factor receptor binding (GO:0005111) | 0.002498 | 0.02123 | 555.17 | 3326.77 |
| 3 | interleukin-17 receptor activity (GO:0030368) | 0.003994 | 0.02263 | 317.19 | 1751.86 |
| 4 | peptide hormone receptor binding (GO:0051428) | 0.006979 | 0.02366 | 170.74 | 847.70 |
| 5 | neuropeptide receptor binding (GO:0071855) | 0.008966 | 0.02366 | 130.54 | 615.43 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cilium (GO:0005929) | 0.1124 | 0.4624 | 9.30 | 20.33 |
| 2 | Golgi membrane (GO:0000139) | 0.2125 | 0.4624 | 4.60 | 7.13 |
| 3 | integral component of plasma membrane (GO:0005887) | 0.1613 | 0.4624 | 3.19 | 5.82 |
| 4 | neuron projection (GO:0043005) | 0.2457 | 0.4624 | 3.89 | 5.46 |
| 5 | nucleolus (GO:0005730) | 0.3117 | 0.4624 | 2.92 | 3.41 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| FGF8 | – |
| KAL1 | – |
| GNRH1 | ZALCITABINE, GOSERELIN, AMINOGLUTETHIMIDE, DITIOCARB, DAPSONE, CAPTOPRIL |
| TAC3 | LIOTHYRONINE SODIUM |
| FEZF1 | – |
| CHD7 | – |
| PROKR2 | – |
| KISS1R | – |
| IL17RD | – |
| KISS1 | – |
