Anorexia (HP:0002039)
A lack or loss of appetite for food (as a medical condition).
Synonyms: Anorexia
Comment: Note that this term does not refer to the condition anorexia nervosa (A disorder characterized by an obsessive desire to lose weight by refusing to eat).
Cross References: MSH:D000855, SNOMEDCT_US:79890006, UMLS:C0003123
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Chronic myeloid leukemia | 0.000006207 | 0.0002193 | 116.93 | 1401.96 |
| 2 | Primary immunodeficiency | 0.0001567 | 0.001186 | 138.57 | 1214.06 |
| 3 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 0.000009993 | 0.0002468 | 99.19 | 1142.03 |
| 4 | Homologous recombination | 0.0001826 | 0.001290 | 127.89 | 1100.92 |
| 5 | AGE-RAGE signaling pathway in diabetic complications | 0.00001419 | 0.0002468 | 87.89 | 981.15 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of histone H3-K9 acetylation (GO:2000617) | 0.000002248 | 0.0002439 | 1665.58 | 21661.60 |
| 2 | positive thymic T cell selection (GO:0045059) | 0.000002248 | 0.0002439 | 1665.58 | 21661.60 |
| 3 | regulation of histone H3-K9 acetylation (GO:2000615) | 0.00001235 | 0.001072 | 555.03 | 6273.06 |
| 4 | positive regulation of histone H3-K4 methylation (GO:0051571) | 0.00002354 | 0.001459 | 384.17 | 4094.01 |
| 5 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 0.00002690 | 0.001459 | 356.71 | 3753.85 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Y-form DNA binding (GO:0000403) | 0.002498 | 0.02034 | 555.17 | 3326.77 |
| 2 | R-SMAD binding (GO:0070412) | 0.00003830 | 0.002183 | 293.72 | 2987.15 |
| 3 | non-membrane spanning protein tyrosine phosphatase activity (GO:0004726) | 0.002997 | 0.02135 | 444.11 | 2580.41 |
| 4 | cyclin-dependent protein serine/threonine kinase inhibitor activity (GO:0004861) | 0.004990 | 0.02844 | 246.68 | 1307.49 |
| 5 | I-SMAD binding (GO:0070411) | 0.006482 | 0.03194 | 184.98 | 932.06 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | T cell receptor complex (GO:0042101) | 1.975e-8 | 5.136e-7 | 951.48 | 16879.14 |
| 2 | alpha-beta T cell receptor complex (GO:0042105) | 0.000003371 | 0.00004383 | 1249.13 | 15739.23 |
| 3 | Cul4A-RING E3 ubiquitin ligase complex (GO:0031464) | 0.005488 | 0.03890 | 222.00 | 1155.57 |
| 4 | early phagosome (GO:0032009) | 0.005985 | 0.03890 | 201.81 | 1032.95 |
| 5 | Cul4-RING E3 ubiquitin ligase complex (GO:0080008) | 0.01687 | 0.07312 | 67.20 | 274.29 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| BRCA1 | – |
| SMAD4 | LYSINE, ALECTINIB |
| KRAS | PANITUMUMAB, CETUXIMAB |
| CDKN1B | RALTITREXED |
| PTPN22 | – |
| CD3D | MUROMMONAB-CD3, CATUMAXOMAB, BLINATUMOMAB |
| CD3E | MUROMMONAB-CD3, CATUMAXOMAB, BLINATUMOMAB |
| SYK | FOSTAMATINIB |
| MEN1 | OLSALAZINE |
| PALB2 | OLAPARIB, MITOMYCIN |
