Anomic aphasia (HP:0030784)
An inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name.
Synonyms: Word-finding difficulty, Amnesic aphasia, Amnestic aphasia, Anomia, Nominal aphasia
Pubmed References: PMID:18348092
Cross References: MSH:D000849, SNOMEDCT_US:10325006, UMLS:C0003113
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Osteoclast differentiation | 0.02516 | 0.08973 | 52.57 | 193.57 |
| 2 | Parkinson disease | 0.04888 | 0.08973 | 26.54 | 80.12 |
| 3 | MAPK signaling pathway | 0.05752 | 0.08973 | 22.42 | 64.01 |
| 4 | Alzheimer disease | 0.07179 | 0.08973 | 17.78 | 46.83 |
| 5 | Pathways of neurodegeneration | 0.09168 | 0.09168 | 13.73 | 32.80 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | microglial cell activation (GO:0001774) | 0.000006921 | 0.001545 | 998.80 | 11866.74 |
| 2 | regulation of hippocampal neuron apoptotic process (GO:0110089) | 0.0009997 | 0.008525 | 1666.00 | 11508.86 |
| 3 | negative regulation of tubulin deacetylation (GO:1904428) | 0.0009997 | 0.008525 | 1666.00 | 11508.86 |
| 4 | positive regulation of protein localization to synapse (GO:1902474) | 0.0009997 | 0.008525 | 1666.00 | 11508.86 |
| 5 | chemokine (C-X-C motif) ligand 12 signaling pathway (GO:0038146) | 0.0009997 | 0.008525 | 1666.00 | 11508.86 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | apolipoprotein A-I binding (GO:0034186) | 0.0009997 | 0.008116 | 1666.00 | 11508.86 |
| 2 | lipoprotein particle binding (GO:0071813) | 0.000008268 | 0.0002398 | 907.91 | 10625.40 |
| 3 | sulfatide binding (GO:0120146) | 0.001200 | 0.008116 | 1332.73 | 8963.74 |
| 4 | high-density lipoprotein particle binding (GO:0008035) | 0.001200 | 0.008116 | 1332.73 | 8963.74 |
| 5 | minor groove of adenine-thymine-rich DNA binding (GO:0003680) | 0.001399 | 0.008116 | 1110.56 | 7298.30 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neurofibrillary tangle (GO:0097418) | 0.0009997 | 0.006498 | 1666.00 | 11508.86 |
| 2 | glial cell projection (GO:0097386) | 0.002797 | 0.01212 | 512.38 | 3012.37 |
| 3 | membrane raft (GO:0045121) | 0.0003919 | 0.005094 | 123.20 | 966.45 |
| 4 | plasma membrane raft (GO:0044853) | 0.01630 | 0.05298 | 81.95 | 337.37 |
| 5 | microtubule (GO:0005874) | 0.03591 | 0.08599 | 36.49 | 121.40 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| MAPT | – |
| TREM2 | – |
| C9orf72 | – |
| PLP1 | – |
