Agnosia (HP:0010524)
Inability to recognize objects not because of sensory deficit but because of the inability to combine components of sensory impressions into a complete pattern. Thus, agnosia is a neurological condition which results in an inability to know, to name, to identify, and to extract meaning from visual, auditory, or tactile impressions.
Synonyms: No synonyms found for this term.
Cross References: MSH:D000377, SNOMEDCT_US:42341009, UMLS:C0001816
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Aldosterone-regulated sodium reabsorption | 0.0001189 | 0.003782 | 162.91 | 1472.21 |
| 2 | Fanconi anemia pathway | 0.0002545 | 0.003782 | 109.55 | 906.71 |
| 3 | Endometrial cancer | 0.0002937 | 0.003782 | 101.71 | 827.20 |
| 4 | VEGF signaling pathway | 0.0003039 | 0.003782 | 99.92 | 809.23 |
| 5 | GnRH secretion | 0.0003577 | 0.003782 | 91.84 | 728.82 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of amyloid-beta clearance (GO:1900223) | 0.000003775 | 0.0008690 | 1142.06 | 14260.84 |
| 2 | positive regulation of apoptotic cell clearance (GO:2000427) | 0.000005033 | 0.0008690 | 951.67 | 11609.88 |
| 3 | positive regulation of phagocytosis, engulfment (GO:0060100) | 0.000006469 | 0.0008690 | 815.67 | 9746.03 |
| 4 | regulation of amyloid-beta clearance (GO:1900221) | 0.00002153 | 0.002169 | 407.69 | 4381.12 |
| 5 | regulation of astrocyte activation (GO:0061888) | 0.002248 | 0.01960 | 624.59 | 3808.55 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | DNA insertion or deletion binding (GO:0032135) | 0.002248 | 0.01560 | 624.59 | 3808.55 |
| 2 | phosphatidylcholine floppase activity (GO:0090554) | 0.002248 | 0.01560 | 624.59 | 3808.55 |
| 3 | apolipoprotein A-I binding (GO:0034186) | 0.002248 | 0.01560 | 624.59 | 3808.55 |
| 4 | sulfatide binding (GO:0120146) | 0.002697 | 0.01560 | 499.65 | 2955.69 |
| 5 | high-density lipoprotein particle binding (GO:0008035) | 0.002697 | 0.01560 | 499.65 | 2955.69 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | glial cell projection (GO:0097386) | 0.00001633 | 0.0006207 | 475.69 | 5243.18 |
| 2 | phosphatidylinositol 3-kinase complex, class I (GO:0097651) | 0.002248 | 0.02174 | 624.59 | 3808.55 |
| 3 | neurofibrillary tangle (GO:0097418) | 0.002248 | 0.02174 | 624.59 | 3808.55 |
| 4 | proton-transporting V-type ATPase complex (GO:0033176) | 0.006731 | 0.05116 | 178.37 | 892.01 |
| 5 | vacuolar proton-transporting V-type ATPase complex (GO:0016471) | 0.008519 | 0.05395 | 138.70 | 660.97 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| TREM2 | – |
| MAPT | – |
| PIK3CA | – |
| PMS2 | NIVOLUMAB |
| ABCA7 | – |
| KRAS | PANITUMUMAB, CETUXIMAB |
| C9orf72 | – |
| FAN1 | – |
| ATP6AP2 | – |
