Aggressive behavior (HP:0000718)
Aggressive behavior can denote verbal aggression, physical aggression against objects, physical aggression against people, and may also include aggression towards oneself.
Synonyms: Aggression, Aggressive behavior, Aggressive behaviour, Aggressiveness, physical aggression
Cross References: MSH:D000374, SNOMEDCT_US:248004009, SNOMEDCT_US:61372001, UMLS:C0001807, UMLS:C0424323, UMLS:C1457883
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Thyroid hormone signaling pathway | 0.00002513 | 0.0008041 | 72.17 | 764.43 |
| 2 | Notch signaling pathway | 0.0003792 | 0.001952 | 87.43 | 688.70 |
| 3 | Long-term potentiation | 0.0004889 | 0.001952 | 76.63 | 584.21 |
| 4 | Renal cell carcinoma | 0.0005185 | 0.001952 | 74.34 | 562.35 |
| 5 | Adherens junction | 0.0005489 | 0.001952 | 72.18 | 541.87 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | peptidyl-lysine acetylation (GO:0018394) | 0.00001010 | 0.0001479 | 624.44 | 7182.69 |
| 2 | chromatin-mediated maintenance of transcription (GO:0048096) | 0.00001235 | 0.0001687 | 555.03 | 6273.06 |
| 3 | chromatin organization involved in regulation of transcription (GO:0034401) | 0.00001750 | 0.0002242 | 454.07 | 4973.59 |
| 4 | chromatin remodeling (GO:0006338) | 8.107e-10 | 1.662e-7 | 202.98 | 4248.99 |
| 5 | N-terminal protein amino acid acetylation (GO:0006474) | 0.00002690 | 0.0003064 | 356.71 | 3753.85 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor (GO:0004468) | 0.002498 | 0.009989 | 555.17 | 3326.77 |
| 2 | histone demethylase activity (H3-trimethyl-K4 specific) (GO:0034647) | 0.002498 | 0.009989 | 555.17 | 3326.77 |
| 3 | STAT family protein binding (GO:0097677) | 0.002997 | 0.009989 | 444.11 | 2580.41 |
| 4 | DNA-methyltransferase activity (GO:0009008) | 0.002997 | 0.009989 | 444.11 | 2580.41 |
| 5 | S-methyltransferase activity (GO:0008172) | 0.003495 | 0.01075 | 370.07 | 2093.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | nBAF complex (GO:0071565) | 3.267e-8 | 3.267e-7 | 778.40 | 13417.28 |
| 2 | SWI/SNF complex (GO:0016514) | 8.685e-8 | 4.342e-7 | 535.02 | 8698.92 |
| 3 | npBAF complex (GO:0071564) | 0.00001235 | 0.00004115 | 555.03 | 6273.06 |
| 4 | NURF complex (GO:0016589) | 0.002498 | 0.004163 | 555.17 | 3326.77 |
| 5 | ISWI-type complex (GO:0031010) | 0.004990 | 0.006859 | 246.68 | 1307.49 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| EP300 | – |
| CREBBP | – |
| ARID1A | ATEZOLIZUMAB, NIVOLUMAB, PEMBROLIZUMAB |
| DNMT3A | DECITABINE, IDARUBICIN, WARFARIN |
| KDM5C | EVEROLIMUS, SUNTINIB |
| SIN3A | – |
| SETD2 | – |
| SMARCC2 | – |
| BPTF | – |
| ARID1B | – |
