Abnormality of the digestive system (HP:0025031)
Synonyms: No synonyms found for this term.
Comment: Any anomaly of the digestive system, a collection of organs that is made up of the gastrointestinal tract and the liver, pancreas, and gallbladder. The gastrointestinal tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus, including the mouth, esophagus, stomach, small intestine, large intestine and anus.
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | axoneme assembly (GO:0035082) | 2.534e-18 | 9.374e-17 | 1725.20 | 69899.68 |
| 2 | regulation of cilium movement (GO:0003352) | 6.605e-12 | 8.147e-11 | 2220.44 | 57161.21 |
| 3 | determination of digestive tract left/right asymmetry (GO:0071907) | 3.147e-9 | 2.911e-8 | 2141.36 | 41921.23 |
| 4 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 7.548e-9 | 5.072e-8 | 1427.43 | 26695.75 |
| 5 | determination of pancreatic left/right asymmetry (GO:0035469) | 0.000002248 | 0.000004621 | 1665.58 | 21661.60 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | protein homodimerization activity (GO:0042803) | 0.2762 | 0.2762 | 3.39 | 4.36 |
GO: Cellular Conponent
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cilium (GO:0005929) | 0.000003817 | 0.00002672 | 56.53 | 705.26 |
| 2 | motile cilium (GO:0031514) | 0.0005036 | 0.001763 | 75.47 | 573.09 |
| 3 | nucleolus (GO:0005730) | 0.3117 | 0.5529 | 2.92 | 3.41 |
| 4 | nuclear lumen (GO:0031981) | 0.3159 | 0.5529 | 2.87 | 3.31 |
| 5 | intracellular non-membrane-bounded organelle (GO:0043232) | 0.4493 | 0.6290 | 1.81 | 1.45 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| DRC1 | – |
| CCDC65 | – |
| HYDIN | – |
| RSPH4A | – |
| RSPH1 | – |
| CCDC103 | – |
| HEATR2 | – |
| DYX1C1 | – |
| CCDC40 | – |
| CCDC39 | – |
