Abnormal pericardium morphology (HP:0001697)
An abnormality of the pericardium, i.e., of the fluid filled sac that surrounds the heart and the proximal ends of the aorta, vena cava, and the pulmonary artery.
Synonyms:Abnormality of the pericardium
Cross References:Fyler:1900, UMLS:C4025754
KEGG pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Autoimmune thyroid disease | 0.000002081 | 0.0001145 | 170.91 | 2236.02 |
| 2 | Allograft rejection | 0.0001567 | 0.002763 | 138.57 | 1214.06 |
| 3 | Graft-versus-host disease | 0.0001917 | 0.002763 | 124.69 | 1067.29 |
| 4 | Type I diabetes mellitus | 0.0002010 | 0.002763 | 121.64 | 1035.45 |
| 5 | Inflammatory bowel disease | 0.0004602 | 0.005062 | 79.08 | 607.60 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of natural killer cell proliferation (GO:0032817) | 0.000004719 | 0.0002982 | 999.25 | 12254.80 |
| 2 | positive regulation of memory T cell differentiation (GO:0043382) | 0.000008085 | 0.0003505 | 713.68 | 8368.26 |
| 3 | regulation of memory T cell differentiation (GO:0043380) | 0.00001010 | 0.0003536 | 624.44 | 7182.69 |
| 4 | negative regulation of B cell proliferation (GO:0030889) | 0.00001481 | 0.0004712 | 499.50 | 5554.53 |
| 5 | negative regulation of interleukin-10 production (GO:0032693) | 0.00003048 | 0.0008889 | 332.92 | 3461.84 |
GO: Molecular function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | IgG binding (GO:0019864) | 0.002498 | 0.01940 | 555.17 | 3326.77 |
| 2 | ATP-activated inward rectifier potassium channel activity (GO:0015272) | 0.002997 | 0.01940 | 444.11 | 2580.41 |
| 3 | interleukin-12 receptor binding (GO:0005143) | 0.002997 | 0.01940 | 444.11 | 2580.41 |
| 4 | non-membrane spanning protein tyrosine phosphatase activity (GO:0004726) | 0.002997 | 0.01940 | 444.11 | 2580.41 |
| 5 | myosin heavy chain binding (GO:0032036) | 0.003495 | 0.01940 | 370.07 | 2093.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cardiac myofibril (GO:0097512) | 0.002498 | 0.02498 | 555.17 | 3326.77 |
| 2 | CD95 death-inducing signaling complex (GO:0031265) | 0.002498 | 0.02498 | 555.17 | 3326.77 |
| 3 | death-inducing signaling complex (GO:0031264) | 0.003994 | 0.02662 | 317.19 | 1751.86 |
| 4 | MHC class II protein complex (GO:0042613) | 0.006482 | 0.03704 | 184.98 | 932.06 |
| 5 | cation-transporting ATPase complex (GO:0090533) | 0.007973 | 0.03986 | 147.96 | 714.91 |
Hub genes as predicted biomarker & predicted FDA approved drugs
| Hub genes (ranked) | FDA approved drugs |
| CTLA4 | IPILIMUMAB, ABATACEPT |
| PTPN22 | – |
| HLA-DRB1 | CLAVULANIC ACID, PITAVASTATIN |
| IL23R | – |
| MYBPC3 | – |
| CCBE1 | – |
| FAS | TENIPOSIDE |
| FCGR2B | – |
| ABCC9 | NICORANDIL, PINACIDIL, TOLBUTAMIDE, GLIMEPIRIDE |
| PTPN14 | – |
