Abnormal female reproductive system physiology (HP:0030012)
Synonyms: Abnormal female reproductive system physiology, Abnormal female genital system physiology
Cross References: UMLS:C4020714, UMLS:C4022678
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | GnRH secretion | 0.000003690 | 0.00002583 | 140.02 | 1751.57 |
| 2 | Neuroactive ligand-receptor interaction | 3.287e-7 | 0.000004602 | 58.49 | 873.21 |
| 3 | GnRH signaling pathway | 0.0009395 | 0.004384 | 54.67 | 381.04 |
| 4 | Melanoma | 0.03543 | 0.1240 | 31.17 | 104.12 |
| 5 | Breast cancer | 0.07113 | 0.1448 | 15.10 | 39.92 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neuroepithelial cell differentiation (GO:0060563) | 0.002997 | 0.03670 | 444.11 | 2580.41 |
| 2 | negative regulation of striated muscle tissue development (GO:0045843) | 0.003495 | 0.03670 | 370.07 | 2093.27 |
| 3 | regulation of growth hormone secretion (GO:0060123) | 0.003495 | 0.03670 | 370.07 | 2093.27 |
| 4 | nose development (GO:0043584) | 0.003495 | 0.03670 | 370.07 | 2093.27 |
| 5 | limb development (GO:0060173) | 0.00009070 | 0.007618 | 184.84 | 1720.52 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | type 1 fibroblast growth factor receptor binding (GO:0005105) | 0.002498 | 0.02123 | 555.17 | 3326.77 |
| 2 | type 2 fibroblast growth factor receptor binding (GO:0005111) | 0.002498 | 0.02123 | 555.17 | 3326.77 |
| 3 | interleukin-17 receptor activity (GO:0030368) | 0.003994 | 0.02263 | 317.19 | 1751.86 |
| 4 | peptide hormone receptor binding (GO:0051428) | 0.006979 | 0.02366 | 170.74 | 847.70 |
| 5 | neuropeptide receptor binding (GO:0071855) | 0.008966 | 0.02366 | 130.54 | 615.43 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cilium (GO:0005929) | 0.1124 | 0.4624 | 9.30 | 20.33 |
| 2 | Golgi membrane (GO:0000139) | 0.2125 | 0.4624 | 4.60 | 7.13 |
| 3 | integral component of plasma membrane (GO:0005887) | 0.1613 | 0.4624 | 3.19 | 5.82 |
| 4 | neuron projection (GO:0043005) | 0.2457 | 0.4624 | 3.89 | 5.46 |
| 5 | nucleolus (GO:0005730) | 0.3117 | 0.4624 | 2.92 | 3.41 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| GNRH1 | ZALCITABINE, GOSERELIN, AMINOGLUTETHIMIDE, DITIOCARB, DAPSONE, CAPTOPRIL |
| GNRHR | NAFARELIN, GONADORELIN, GANIRELIX ACETATE, DEGARELIX, CETRORELIX, ABARELIX, BUSERELIN, ELAGOLIX, LEUPROLIDE, TRIPTORELIN PAMOATE |
| KISS1R | – |
| KAL1 | – |
| TAC3 | LIOTHYRONINE SODIUM |
| FGF8 | – |
| FEZF1 | – |
| CHD7 | – |
| KISS1 | – |
| IL17RD | – |
