Abnormal calcium-phosphate regulating hormone level (HP:0100530)
Any deviation from the normal concentration in the blood circulation of a hormone that is involved in the regulation of phosphate and calcium.
Synonyms: Abnormal Ca-PHOS regulating hormone level, Abnormal Ca2+ PO4 regulating hormone level
Cross References: UMLS:C4022031
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Parathyroid hormone synthesis, secretion and action | 3.963e-12 | 1.189e-10 | 298.35 | 7832.87 |
| 2 | Mineral absorption | 1.516e-8 | 2.274e-7 | 237.31 | 4272.71 |
| 3 | Endocrine and other factor-regulated calcium reabsorption | 0.000002081 | 0.00002081 | 170.91 | 2236.02 |
| 4 | Ascorbate and aldarate metabolism | 0.01490 | 0.07865 | 76.48 | 321.69 |
| 5 | Citrate cycle (TCA cycle) | 0.01490 | 0.07865 | 76.48 | 321.69 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | cellular trivalent inorganic anion homeostasis (GO:0072502) | 0.000003371 | 0.0003860 | 1249.13 | 15739.23 |
| 2 | cellular phosphate ion homeostasis (GO:0030643) | 0.000003371 | 0.0003860 | 1249.13 | 15739.23 |
| 3 | phosphate ion homeostasis (GO:0055062) | 0.00001010 | 0.0007712 | 624.44 | 7182.69 |
| 4 | phosphate ion transport (GO:0006817) | 0.00003048 | 0.001745 | 332.92 | 3461.84 |
| 5 | cellular response to vitamin D (GO:0071305) | 0.002498 | 0.02737 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | sodium:phosphate symporter activity (GO:0005436) | 0.00001235 | 0.0004691 | 555.03 | 6273.06 |
| 2 | beta-glucosidase activity (GO:0008422) | 0.002997 | 0.02845 | 444.11 | 2580.41 |
| 3 | glucosidase activity (GO:0015926) | 0.003994 | 0.02845 | 317.19 | 1751.86 |
| 4 | solute:sodium symporter activity (GO:0015370) | 0.00009715 | 0.001846 | 178.23 | 1646.74 |
| 5 | phosphatidylethanolamine binding (GO:0008429) | 0.004492 | 0.02845 | 277.53 | 1500.17 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | brush border membrane (GO:0031526) | 0.01835 | 0.07799 | 61.59 | 246.23 |
| 2 | axon (GO:0030424) | 0.004415 | 0.03054 | 24.49 | 132.81 |
| 3 | vesicle (GO:0031982) | 0.005389 | 0.03054 | 22.06 | 115.23 |
| 4 | integral component of plasma membrane (GO:0005887) | 0.0003728 | 0.006338 | 12.80 | 101.01 |
| 5 | cell projection membrane (GO:0031253) | 0.04507 | 0.1277 | 24.30 | 75.31 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| PTH | IBANDRONIC ACID, CLOMIPHENE, CALCITONIN, TRILOSTANE, TERIPARATIDE, PENICILLAMINE, HYDROXYUREA, RANITIDINE |
| VDR | CALCIUM, DIHYDROTACHYSTEROL |
| KL | – |
| SLC34A3 | – |
| CASR | CINACALCET, VELCALCETIDE, CINACALCET HYDROCHLORIDE, PAMIDRONIC ACID |
| SLC34A1 | – |
| RET | CABOZANTINIB, VANDETANIB |
| NF1 | TRAMETINIB, BINIMETINIB, COBIMETINIB, DABRAFENIB, VEMURAFENIB |
| TRPV6 | – |
| SDHC | – |
