Abdominal pain (HP:0002027)
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
Synonyms: Gastro pain, Gastrointestinal pain, Abdominal pain, Pain in stomach, Abdominal discomfort, Stomach pain, Upset stomach
Comment: Abdominal pain can be crampy, achy, dull, intermittent or sharp. The terms stomach ache and stomach cramps are nonmedical terms often used to describe pain in the mid- or upper abdominal area, even though it is not the case that the (smooth) muscles of the stomach or the abdomen have cramps. Stomach pain is another layperson term commonly used to refer to abdominal pain.
Cross References: MEDDRA:10000081, MSH:D015746, SNOMEDCT_US:21522001, UMLS:C0000737
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Breast cancer | 2.916e-11 | 1.910e-9 | 211.16 | 5122.38 |
| 2 | Pathways in cancer | 1.006e-11 | 1.318e-9 | 148.89 | 3770.13 |
| 3 | Thyroid cancer | 6.931e-7 | 0.000006985 | 251.55 | 3567.44 |
| 4 | Central carbon metabolism in cancer | 2.843e-8 | 9.312e-7 | 201.25 | 3496.91 |
| 5 | Chronic myeloid leukemia | 3.973e-8 | 0.000001041 | 184.43 | 3142.85 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | positive regulation of histone H3-K9 acetylation (GO:2000617) | 0.000002248 | 0.0001365 | 1665.58 | 21661.60 |
| 2 | response to indole-3-methanol (GO:0071680) | 0.000002248 | 0.0001365 | 1665.58 | 21661.60 |
| 3 | cellular response to indole-3-methanol (GO:0071681) | 0.000002248 | 0.0001365 | 1665.58 | 21661.60 |
| 4 | positive regulation of histone H3-K4 methylation (GO:0051571) | 4.082e-8 | 0.00002302 | 713.50 | 12139.53 |
| 5 | regulation of histone H3-K4 methylation (GO:0051569) | 8.685e-8 | 0.00002449 | 535.02 | 8698.92 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | I-SMAD binding (GO:0070411) | 0.00001750 | 0.0005512 | 454.07 | 4973.59 |
| 2 | RNA polymerase II general transcription initiation factor binding (GO:0001091) | 0.002498 | 0.01311 | 555.17 | 3326.77 |
| 3 | transcription coactivator binding (GO:0001223) | 0.00004255 | 0.0008935 | 277.39 | 2791.90 |
| 4 | transcription coregulator binding (GO:0001221) | 0.000002081 | 0.0001311 | 170.91 | 2236.02 |
| 5 | 1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005) | 0.003495 | 0.01694 | 370.07 | 2093.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phosphatidylinositol 3-kinase complex, class I (GO:0097651) | 0.002498 | 0.04538 | 555.17 | 3326.77 |
| 2 | Cul4A-RING E3 ubiquitin ligase complex (GO:0031464) | 0.005488 | 0.04538 | 222.00 | 1155.57 |
| 3 | beta-catenin-TCF complex (GO:1990907) | 0.006482 | 0.04538 | 184.98 | 932.06 |
| 4 | intercalated disc (GO:0014704) | 0.01540 | 0.04725 | 73.93 | 308.54 |
| 5 | catenin complex (GO:0016342) | 0.01540 | 0.04725 | 73.93 | 308.54 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| KRAS | PANITUMUMAB, CETUXIMAB |
| SMAD4 | LYSINE, ALECTINIB |
| CTNNB1 | FLUORESCEN SODIUM |
| ESR1 | CLOMIPHENE, LEVONORGESTREL |
| PIK3CA | – |
| RET | CABOZANTINIB, VANDETANIB |
| KIT | NILOTINIB, IMATINIB |
| NF1 | TRAMETINIB, BINIMETINIB, COBIMETINIB, DABRAFENIB, VEMURAFENIB |
| BRCA1 | – |
| CDKN1B | RALTITREXED |
