Antinuclear antibody positivity – GO

May 20, 2022 Off By admin

Antinuclear antibody positivity (HP:0003493)

GENE ONTOLOGY

GO: Biological Process

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	T cell apoptotic process (GO:0070231)	3.147e-9	0.000001026	2141.36	41921.23
2	lymphocyte apoptotic process (GO:0070227)	0.000003371	0.0002005	1249.13	15739.23
3	negative regulation of B cell proliferation (GO:0030889)	0.00001481	0.0004023	499.50	5554.53
4	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)	5.342e-7	0.00008708	275.93	3985.12
5	necroptotic process (GO:0070266)	0.00002690	0.0006264	356.71	3753.85
6	positive regulation of necrotic cell death (GO:0010940)	0.002498	0.01429	555.17	3326.77
7	positive regulation of cell fate commitment (GO:0010455)	0.002498	0.01429	555.17	3326.77
8	negative regulation of dendritic cell differentiation (GO:2001199)	0.002498	0.01429	555.17	3326.77
9	negative regulation of immunoglobulin production (GO:0002638)	0.002498	0.01429	555.17	3326.77
10	positive regulation of toll-like receptor 9 signaling pathway (GO:0034165)	0.002498	0.01429	555.17	3326.77
11	negative regulation of leukocyte differentiation (GO:1902106)	0.002498	0.01429	555.17	3326.77
12	regulation of neutrophil activation (GO:1902563)	0.002498	0.01429	555.17	3326.77
13	negative regulation of regulatory T cell differentiation (GO:0045590)	0.002498	0.01429	555.17	3326.77
14	programmed necrotic cell death (GO:0097300)	0.00003428	0.0007450	312.09	3208.63
15	regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041)	0.000001023	0.0001111	219.24	3024.01
16	negative regulation of B cell receptor signaling pathway (GO:0050859)	0.002997	0.01458	444.11	2580.41
17	regulation of T-helper 17 cell lineage commitment (GO:2000328)	0.002997	0.01458	444.11	2580.41
18	positive regulation of toll-like receptor 3 signaling pathway (GO:0034141)	0.002997	0.01458	444.11	2580.41
19	positive regulation of toll-like receptor 7 signaling pathway (GO:0034157)	0.002997	0.01458	444.11	2580.41
20	regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway (GO:0070432)	0.002997	0.01458	444.11	2580.41
21	negative regulation of B cell activation (GO:0050869)	0.00005170	0.0009914	249.63	2463.82
22	negative regulation of lymphocyte activation (GO:0051250)	0.00005170	0.0009914	249.63	2463.82
23	regulation of B cell receptor signaling pathway (GO:0050855)	0.00005661	0.001025	237.73	2324.81
24	positive regulation of oxidative stress-induced cell death (GO:1903209)	0.003495	0.01458	370.07	2093.27
25	flavin-containing compound metabolic process (GO:0042726)	0.003495	0.01458	370.07	2093.27
26	regulation of T cell tolerance induction (GO:0002664)	0.003495	0.01458	370.07	2093.27
27	regulation of toll-like receptor 7 signaling pathway (GO:0034155)	0.003495	0.01458	370.07	2093.27
28	positive regulation of T-helper 17 cell differentiation (GO:2000321)	0.003495	0.01458	370.07	2093.27
29	release of sequestered calcium ion into cytosol by endoplasmic reticulum (GO:1903514)	0.003495	0.01458	370.07	2093.27
30	death-inducing signaling complex assembly (GO:0071550)	0.003495	0.01458	370.07	2093.27
31	regulation of natural killer cell proliferation (GO:0032817)	0.003495	0.01458	370.07	2093.27
32	regulation of necrotic cell death (GO:0010939)	0.003495	0.01458	370.07	2093.27
33	positive regulation of humoral immune response (GO:0002922)	0.003495	0.01458	370.07	2093.27
34	riboflavin metabolic process (GO:0006771)	0.003495	0.01458	370.07	2093.27
35	negative regulation of p38MAPK cascade (GO:1903753)	0.003495	0.01458	370.07	2093.27
36	negative regulation of acute inflammatory response (GO:0002674)	0.003495	0.01458	370.07	2093.27
37	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	0.00006709	0.001094	217.03	2085.58
38	regulation of regulatory T cell differentiation (GO:0045589)	0.00007266	0.001128	207.98	1981.99
39	positive regulation of defense response to virus by host (GO:0002230)	0.00008446	0.001232	191.96	1800.45
40	negative regulation of T cell mediated cytotoxicity (GO:0001915)	0.003994	0.01479	317.19	1751.86
41	store-operated calcium entry (GO:0002115)	0.003994	0.01479	317.19	1751.86
42	regulation of toll-like receptor 3 signaling pathway (GO:0034139)	0.003994	0.01479	317.19	1751.86
43	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001269)	0.003994	0.01479	317.19	1751.86
44	regulation of CD8-positive, alpha-beta T cell proliferation (GO:2000564)	0.003994	0.01479	317.19	1751.86
45	peptidyl-serine autophosphorylation (GO:0036289)	0.003994	0.01479	317.19	1751.86
46	regulation of dendritic spine maintenance (GO:1902950)	0.003994	0.01479	317.19	1751.86
47	regulation of protein K63-linked ubiquitination (GO:1900044)	0.003994	0.01479	317.19	1751.86
48	regulation of extrinsic apoptotic signaling pathway (GO:2001236)	0.000003690	0.0002005	140.02	1751.57
49	regulation of response to biotic stimulus (GO:0002831)	0.00009070	0.001232	184.84	1720.52
50	extrinsic apoptotic signaling pathway (GO:0097191)	0.000005272	0.0002455	123.73	1503.75
51	cellular response to muramyl dipeptide (GO:0071225)	0.004492	0.01479	277.53	1500.17
52	positive regulation of CD8-positive, alpha-beta T cell activation (GO:2001187)	0.004492	0.01479	277.53	1500.17
53	positive regulation of protein polyubiquitination (GO:1902916)	0.004492	0.01479	277.53	1500.17
54	regulation of T-helper 1 type immune response (GO:0002825)	0.004492	0.01479	277.53	1500.17
55	bone resorption (GO:0045453)	0.004492	0.01479	277.53	1500.17
56	negative regulation of leukocyte degranulation (GO:0043301)	0.004492	0.01479	277.53	1500.17
57	negative regulation of necroptotic process (GO:0060546)	0.004492	0.01479	277.53	1500.17
58	regulation of dendritic cell antigen processing and presentation (GO:0002604)	0.004492	0.01479	277.53	1500.17
59	negative regulation of production of molecular mediator of immune response (GO:0002701)	0.004492	0.01479	277.53	1500.17
60	positive regulation of memory T cell differentiation (GO:0043382)	0.004492	0.01479	277.53	1500.17
61	interleukin-23-mediated signaling pathway (GO:0038155)	0.004492	0.01479	277.53	1500.17
62	B cell receptor signaling pathway (GO:0050853)	0.0001252	0.001632	155.92	1401.11
63	negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	0.000007247	0.0002619	110.83	1311.70
64	regulation of hydrogen peroxide-induced cell death (GO:1903205)	0.004990	0.01516	246.68	1307.49
65	regulation of T-helper 17 type immune response (GO:2000316)	0.004990	0.01516	246.68	1307.49
66	regulation of memory T cell differentiation (GO:0043380)	0.004990	0.01516	246.68	1307.49
67	negative regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002924)	0.004990	0.01516	246.68	1307.49
68	positive regulation of toll-like receptor 4 signaling pathway (GO:0034145)	0.004990	0.01516	246.68	1307.49
69	immunoglobulin mediated immune response (GO:0016064)	0.004990	0.01516	246.68	1307.49
70	regulation of defense response to virus by host (GO:0050691)	0.0001405	0.001761	146.74	1301.62
71	activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919)	0.000007524	0.0002619	109.41	1290.72
72	regulation of T cell differentiation (GO:0045580)	0.0001651	0.001872	134.82	1174.13
73	negative regulation of lymphocyte proliferation (GO:0050672)	0.0001651	0.001872	134.82	1174.13
74	cellular response to increased oxygen levels (GO:0036295)	0.005488	0.01516	222.00	1155.57
75	cellular response to interleukin-2 (GO:0071352)	0.005488	0.01516	222.00	1155.57
76	positive regulation of production of miRNAs involved in gene silencing by miRNA (GO:1903800)	0.005488	0.01516	222.00	1155.57
77	regulation of stress-activated protein kinase signaling cascade (GO:0070302)	0.005488	0.01516	222.00	1155.57
78	regulation of toll-like receptor 9 signaling pathway (GO:0034163)	0.005488	0.01516	222.00	1155.57
79	T cell homeostasis (GO:0043029)	0.005488	0.01516	222.00	1155.57
80	B cell mediated immunity (GO:0019724)	0.005488	0.01516	222.00	1155.57
81	regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001267)	0.005488	0.01516	222.00	1155.57
82	positive regulation of macrophage differentiation (GO:0045651)	0.005488	0.01516	222.00	1155.57
83	negative regulation of programmed necrotic cell death (GO:0062099)	0.005488	0.01516	222.00	1155.57
84	interleukin-2-mediated signaling pathway (GO:0038110)	0.005488	0.01516	222.00	1155.57
85	toll-like receptor 3 signaling pathway (GO:0034138)	0.005985	0.01561	201.81	1032.95
86	positive regulation of T-helper 1 type immune response (GO:0002827)	0.005985	0.01561	201.81	1032.95
87	positive regulation of T-helper 17 type immune response (GO:2000318)	0.005985	0.01561	201.81	1032.95
88	negative regulation of JUN kinase activity (GO:0043508)	0.005985	0.01561	201.81	1032.95
89	regulation of natural killer cell activation (GO:0032814)	0.005985	0.01561	201.81	1032.95
90	regulation of dendritic cell differentiation (GO:2001198)	0.005985	0.01561	201.81	1032.95
91	negative regulation of T cell activation (GO:0050868)	0.0002202	0.002393	115.97	976.58
92	regulation of B cell proliferation (GO:0030888)	0.0002302	0.002420	113.33	949.33
93	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824)	0.006482	0.01638	184.98	932.06
94	mature B cell differentiation involved in immune response (GO:0002313)	0.006482	0.01638	184.98	932.06
95	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	0.006482	0.01638	184.98	932.06
96	response to muramyl dipeptide (GO:0032495)	0.006482	0.01638	184.98	932.06
97	regulation of response to endoplasmic reticulum stress (GO:1905897)	0.006979	0.01724	170.74	847.70
98	negative regulation of T cell differentiation (GO:0045581)	0.006979	0.01724	170.74	847.70
99	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)	0.00002391	0.0005995	73.43	781.36
100	regulation of macrophage differentiation (GO:0045649)	0.007476	0.01766	158.54	776.21
101	negative regulation of leukocyte activation (GO:0002695)	0.007476	0.01766	158.54	776.21
102	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	0.007476	0.01766	158.54	776.21
103	calcium ion import into cytosol (GO:1902656)	0.007476	0.01766	158.54	776.21
104	apoptotic process (GO:0006915)	0.000003448	0.0002005	58.04	730.03
105	cellular response to peptide (GO:1901653)	0.0003539	0.003393	90.61	720.07
106	positive regulation of interferon-gamma production (GO:0032729)	0.0003539	0.003393	90.61	720.07
107	positive regulation of alpha-beta T cell proliferation (GO:0046641)	0.007973	0.01830	147.96	714.91
108	positive regulation of endothelial cell apoptotic process (GO:2000353)	0.007973	0.01830	147.96	714.91
109	B cell activation involved in immune response (GO:0002312)	0.007973	0.01830	147.96	714.91
110	negative regulation of macrophage activation (GO:0043031)	0.007973	0.01830	147.96	714.91
111	positive regulation of apoptotic signaling pathway (GO:2001235)	0.0003792	0.003532	87.43	688.70
112	negative regulation of interleukin-10 production (GO:0032693)	0.008469	0.01917	138.71	661.82
113	negative regulation of phagocytosis (GO:0050765)	0.008469	0.01917	138.71	661.82
114	regulation of innate immune response (GO:0045088)	0.0004462	0.004040	80.35	619.92
115	regulation of adaptive immune response (GO:0002819)	0.008966	0.01962	130.54	615.43
116	positive regulation of response to endoplasmic reticulum stress (GO:1905898)	0.008966	0.01962	130.54	615.43
117	negative regulation of interleukin-8 production (GO:0032717)	0.008966	0.01962	130.54	615.43
118	negative regulation of leukocyte cell-cell adhesion (GO:1903038)	0.008966	0.01962	130.54	615.43
119	regulation of production of miRNAs involved in gene silencing by miRNA (GO:1903798)	0.008966	0.01962	130.54	615.43
120	positive regulation of cell death (GO:0010942)	0.0004745	0.004180	77.84	595.70
121	negative regulation of T cell receptor signaling pathway (GO:0050860)	0.009462	0.02029	123.28	574.57
122	regulation of lymphocyte proliferation (GO:0050670)	0.009462	0.02029	123.28	574.57
123	negative regulation of immune system process (GO:0002683)	0.009462	0.02029	123.28	574.57
124	positive regulation of programmed cell death (GO:0043068)	0.000008035	0.0002619	46.59	546.59
125	positive regulation of activated T cell proliferation (GO:0042104)	0.009957	0.02094	116.79	538.34
126	lipopolysaccharide-mediated signaling pathway (GO:0031663)	0.009957	0.02094	116.79	538.34
127	regulation of programmed necrotic cell death (GO:0062098)	0.009957	0.02094	116.79	538.34
128	response to molecule of bacterial origin (GO:0002237)	0.0005802	0.004729	70.14	522.67
129	positive regulation of JNK cascade (GO:0046330)	0.0005802	0.004729	70.14	522.67
130	extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)	0.01045	0.02157	110.94	506.01
131	neuron apoptotic process (GO:0051402)	0.01045	0.02157	110.94	506.01
132	calcium ion transport into cytosol (GO:0060402)	0.01045	0.02157	110.94	506.01
133	positive regulation of immune response (GO:0050778)	0.0006123	0.004869	68.21	504.62
134	positive regulation of apoptotic process (GO:0043065)	0.00001104	0.0003273	42.88	489.47
135	regulation of interleukin-8 production (GO:0032677)	0.0007138	0.005541	63.01	456.50
136	regulation of toll-like receptor 4 signaling pathway (GO:0034143)	0.01144	0.02303	100.85	450.83
137	positive regulation of epithelial cell apoptotic process (GO:1904037)	0.01144	0.02303	100.85	450.83
138	regulation of necroptotic process (GO:0060544)	0.01144	0.02303	100.85	450.83
139	regulation of defense response (GO:0031347)	0.0007493	0.005681	61.45	442.20
140	lymphocyte differentiation (GO:0030098)	0.0007674	0.005686	60.70	435.34
141	antigen receptor-mediated signaling pathway (GO:0050851)	0.00008908	0.001232	46.64	435.00
142	regulation of interferon-gamma production (GO:0032649)	0.0008042	0.005826	59.24	422.16
143	positive regulation of T cell mediated cytotoxicity (GO:0001916)	0.01293	0.02585	88.73	385.85
144	release of sequestered calcium ion into cytosol (GO:0051209)	0.01342	0.02636	85.32	367.79
145	positive regulation of toll-like receptor signaling pathway (GO:0034123)	0.01342	0.02636	85.32	367.79
146	positive regulation of gene silencing by miRNA (GO:2000637)	0.01342	0.02636	85.32	367.79
147	regulation of immunoglobulin production (GO:0002637)	0.01392	0.02653	82.15	351.18
148	regulation of B cell activation (GO:0050864)	0.01392	0.02653	82.15	351.18
149	calcium ion import (GO:0070509)	0.01392	0.02653	82.15	351.18
150	regulation of plasma membrane bounded cell projection organization (GO:0120035)	0.01392	0.02653	82.15	351.18
151	regulation of postsynapse organization (GO:0099175)	0.01392	0.02653	82.15	351.18
152	positive regulation of stress-activated MAPK cascade (GO:0032874)	0.001064	0.007538	51.27	351.00
153	regulation of T cell mediated cytotoxicity (GO:0001914)	0.01441	0.02700	79.21	335.86
154	positive regulation of extrinsic apoptotic signaling pathway (GO:2001238)	0.01441	0.02700	79.21	335.86
155	regulation of JNK cascade (GO:0046328)	0.001195	0.008290	48.27	324.82
156	extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)	0.01490	0.02714	76.48	321.69
157	regulation of macrophage activation (GO:0043030)	0.01490	0.02714	76.48	321.69
158	TRIF-dependent toll-like receptor signaling pathway (GO:0035666)	0.01490	0.02714	76.48	321.69
159	plasma membrane invagination (GO:0099024)	0.01490	0.02714	76.48	321.69
160	negative regulation of interleukin-6 production (GO:0032715)	0.01540	0.02773	73.93	308.54
161	MyD88-independent toll-like receptor signaling pathway (GO:0002756)	0.01540	0.02773	73.93	308.54
162	B cell proliferation (GO:0042100)	0.01589	0.02830	71.54	296.32
163	positive regulation of immune effector process (GO:0002699)	0.01589	0.02830	71.54	296.32
164	negative regulation of JNK cascade (GO:0046329)	0.01638	0.02902	69.30	284.93
165	regulation of activated T cell proliferation (GO:0046006)	0.01687	0.02974	67.20	274.29
166	cellular response to hydrogen peroxide (GO:0070301)	0.01737	0.02980	65.22	264.33
167	regulation of T cell receptor signaling pathway (GO:0050856)	0.01737	0.02980	65.22	264.33
168	regulation of JUN kinase activity (GO:0043506)	0.01737	0.02980	65.22	264.33
169	peptidyl-tyrosine dephosphorylation (GO:0035335)	0.01737	0.02980	65.22	264.33
170	cellular response to amyloid-beta (GO:1904646)	0.01737	0.02980	65.22	264.33
171	cellular response to cytokine stimulus (GO:0071345)	0.00006234	0.001070	27.21	263.51
172	regulation of tumor necrosis factor production (GO:0032680)	0.001661	0.01128	40.71	260.58
173	positive regulation of myeloid leukocyte differentiation (GO:0002763)	0.01786	0.03017	63.35	255.00
174	positive regulation of cytokine-mediated signaling pathway (GO:0001961)	0.01786	0.03017	63.35	255.00
175	positive regulation of T cell mediated immunity (GO:0002711)	0.01786	0.03017	63.35	255.00
176	negative regulation of stress-activated MAPK cascade (GO:0032873)	0.01835	0.03052	61.59	246.23
177	regulation of p38MAPK cascade (GO:1900744)	0.01835	0.03052	61.59	246.23
178	phagocytosis, engulfment (GO:0006911)	0.01835	0.03052	61.59	246.23
179	regulation of response to external stimulus (GO:0032101)	0.001823	0.01213	38.79	244.67
180	positive regulation of production of molecular mediator of immune response (GO:0002702)	0.01884	0.03087	59.92	237.98
181	lymphocyte proliferation (GO:0046651)	0.01884	0.03087	59.92	237.98
182	regulation of apoptotic signaling pathway (GO:2001233)	0.01884	0.03087	59.92	237.98
183	regulation of ion transmembrane transporter activity (GO:0032412)	0.01933	0.03151	58.34	230.20
184	negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)	0.01983	0.03215	56.84	222.86
185	T cell differentiation (GO:0030217)	0.02032	0.03279	55.42	215.92
186	positive regulation of T cell differentiation (GO:0045582)	0.02130	0.03403	52.77	203.13
187	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	0.02130	0.03403	52.77	203.13
188	response to amyloid-beta (GO:1904645)	0.02179	0.03448	51.54	197.22
189	regulation of endothelial cell apoptotic process (GO:2000351)	0.02179	0.03448	51.54	197.22
190	positive regulation of cytokine production (GO:0001819)	0.0005121	0.004394	25.38	192.27
191	positive regulation of RNA metabolic process (GO:0051254)	0.02228	0.03509	50.37	191.61
192	T cell receptor signaling pathway (GO:0050852)	0.002677	0.01458	31.79	188.27
193	negative regulation of tumor necrosis factor production (GO:0032720)	0.02277	0.03535	49.25	186.27
194	positive regulation of response to stimulus (GO:0048584)	0.02277	0.03535	49.25	186.27
195	interleukin-12-mediated signaling pathway (GO:0035722)	0.02277	0.03535	49.25	186.27
196	cytokine-mediated signaling pathway (GO:0019221)	0.0001665	0.001872	20.93	182.12
197	positive regulation of neuron death (GO:1901216)	0.02326	0.03543	48.17	181.19
198	regulation of T cell activation (GO:0050863)	0.02326	0.03543	48.17	181.19
199	cellular response to interleukin-12 (GO:0071349)	0.02375	0.03551	47.15	176.34
200	negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)	0.02375	0.03551	47.15	176.34
201	regulation of interleukin-10 production (GO:0032653)	0.02375	0.03551	47.15	176.34
202	negative regulation of MAP kinase activity (GO:0043407)	0.02375	0.03551	47.15	176.34
203	cellular response to mechanical stimulus (GO:0071260)	0.02424	0.03559	46.16	171.72
204	regulation of stress-activated MAPK cascade (GO:0032872)	0.02424	0.03559	46.16	171.72
205	positive regulation of reactive oxygen species metabolic process (GO:2000379)	0.02424	0.03559	46.16	171.72
206	response to hydrogen peroxide (GO:0042542)	0.02424	0.03559	46.16	171.72
207	positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	0.003126	0.01458	29.32	169.12
208	negative regulation of transport (GO:0051051)	0.02521	0.03686	44.31	163.08
209	regulation of immune response (GO:0050776)	0.003419	0.01458	27.98	158.91
210	negative regulation of cytokine production (GO:0001818)	0.003532	0.01458	27.51	155.34
211	positive regulation of phagocytosis (GO:0050766)	0.02619	0.03778	42.60	155.17
212	regulation of immune effector process (GO:0002697)	0.02619	0.03778	42.60	155.17
213	cellular macromolecule catabolic process (GO:0044265)	0.02619	0.03778	42.60	155.17
214	regulation of humoral immune response (GO:0002920)	0.02668	0.03832	41.80	151.46
215	regulation of programmed cell death (GO:0043067)	0.004002	0.01479	25.78	142.32
216	regulation of reactive oxygen species metabolic process (GO:2000377)	0.02814	0.04024	39.55	141.22
217	regulation of apoptotic process (GO:0042981)	0.0003300	0.003361	17.39	139.42
218	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	0.02863	0.04058	38.86	138.07
219	regulation of phagocytosis (GO:0050764)	0.02863	0.04058	38.86	138.07
220	negative regulation of autophagy (GO:0010507)	0.02912	0.04092	38.18	135.03
221	cellular protein catabolic process (GO:0044257)	0.02960	0.04142	37.53	132.12
222	negative regulation of response to stimulus (GO:0048585)	0.03009	0.04157	36.91	129.31
223	B cell differentiation (GO:0030183)	0.03009	0.04157	36.91	129.31
224	positive regulation of interleukin-8 production (GO:0032757)	0.03009	0.04157	36.91	129.31
225	I-kappaB kinase/NF-kappaB signaling (GO:0007249)	0.03058	0.04206	36.30	126.60
226	positive regulation of protein modification process (GO:0031401)	0.004846	0.01516	23.32	124.30
227	cellular response to reactive oxygen species (GO:0034614)	0.03106	0.04237	35.71	123.99
228	amyloid fibril formation (GO:1990000)	0.03106	0.04237	35.71	123.99
229	protein catabolic process (GO:0030163)	0.03155	0.04286	35.14	121.47
230	positive regulation of T cell proliferation (GO:0042102)	0.03252	0.04399	34.06	116.68
231	regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	0.005297	0.01516	22.26	116.66
232	inflammatory response (GO:0006954)	0.005576	0.01527	21.67	112.45
233	negative regulation of cellular catabolic process (GO:0031330)	0.03398	0.04577	32.55	110.09
234	protein tetramerization (GO:0051262)	0.03495	0.04669	31.62	106.05
235	Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)	0.03495	0.04669	31.62	106.05
236	Fc-gamma receptor signaling pathway (GO:0038094)	0.03543	0.04714	31.17	104.12
237	Fc receptor mediated stimulatory signaling pathway (GO:0002431)	0.03640	0.04785	30.32	100.44
238	regulation of cytokine-mediated signaling pathway (GO:0001959)	0.03640	0.04785	30.32	100.44
239	cellular response to amino acid starvation (GO:0034198)	0.03640	0.04785	30.32	100.44
240	response to amino acid starvation (GO:1990928)	0.03688	0.04829	29.90	98.68
241	positive regulation of phosphorylation (GO:0042327)	0.006708	0.01682	19.66	98.39
242	water-soluble vitamin metabolic process (GO:0006767)	0.03736	0.04872	29.50	96.98
243	positive regulation of tumor necrosis factor production (GO:0032760)	0.03785	0.04896	29.11	95.32
244	positive regulation of type I interferon production (GO:0032481)	0.03785	0.04896	29.11	95.32
245	negative regulation of apoptotic signaling pathway (GO:2001234)	0.03833	0.04920	28.73	93.72
246	negative regulation of blood vessel morphogenesis (GO:2000181)	0.03833	0.04920	28.73	93.72
247	regulation of protein phosphorylation (GO:0001932)	0.007391	0.01766	18.68	91.67
248	protein-containing complex assembly (GO:0065003)	0.007445	0.01766	18.61	91.19
249	response to interferon-gamma (GO:0034341)	0.03930	0.05004	28.00	90.64
250	regulation of NIK/NF-kappaB signaling (GO:1901222)	0.03930	0.05004	28.00	90.64
251	positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)	0.03978	0.05046	27.65	89.16
252	B cell activation (GO:0042113)	0.04171	0.05270	26.33	83.66
253	regulation of neuron death (GO:1901214)	0.04219	0.05310	26.02	82.37
254	negative regulation of angiogenesis (GO:0016525)	0.04267	0.05350	25.72	81.12
255	regulation of type I interferon production (GO:0032479)	0.04363	0.05429	25.13	78.70
256	positive regulation of inflammatory response (GO:0050729)	0.04363	0.05429	25.13	78.70
257	protein complex oligomerization (GO:0051259)	0.04411	0.05468	24.85	77.54
258	toll-like receptor signaling pathway (GO:0002224)	0.04459	0.05485	24.57	76.41
259	positive regulation of transport (GO:0051050)	0.04459	0.05485	24.57	76.41
260	T cell activation (GO:0042110)	0.04507	0.05524	24.30	75.31
261	negative regulation of gene expression (GO:0010629)	0.01068	0.02189	15.37	69.76
262	antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)	0.04794	0.05832	22.79	69.22
263	positive regulation of defense response (GO:0031349)	0.04794	0.05832	22.79	69.22
264	antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)	0.04890	0.05926	22.32	67.37
265	cellular response to chemical stress (GO:0062197)	0.04938	0.05962	22.10	66.48
266	antigen processing and presentation of exogenous peptide antigen (GO:0002478)	0.05033	0.06055	21.66	64.76
267	positive regulation of cellular metabolic process (GO:0031325)	0.05129	0.06147	21.25	63.11
268	regulation of interleukin-6 production (GO:0032675)	0.05367	0.06386	20.27	59.28
269	response to tumor necrosis factor (GO:0034612)	0.05367	0.06386	20.27	59.28
270	protein-containing complex subunit organization (GO:0043933)	0.05462	0.06475	19.90	57.85
271	positive regulation of protein phosphorylation (GO:0001934)	0.01400	0.02653	13.29	56.75
272	response to lipid (GO:0033993)	0.05557	0.06564	19.54	56.49
273	cellular response to molecule of bacterial origin (GO:0071219)	0.05605	0.06572	19.37	55.82
274	calcium ion transport (GO:0006816)	0.05605	0.06572	19.37	55.82
275	tumor necrosis factor-mediated signaling pathway (GO:0033209)	0.05652	0.06604	19.20	55.17
276	negative regulation of programmed cell death (GO:0043069)	0.01472	0.02714	12.94	54.57
277	cellular response to lipopolysaccharide (GO:0071222)	0.05842	0.06802	18.55	52.69
278	cellular response to interferon-gamma (GO:0071346)	0.05889	0.06832	18.40	52.10
279	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	0.06597	0.07626	16.34	44.43
280	positive regulation of response to external stimulus (GO:0032103)	0.06738	0.07735	15.98	43.11
281	protein dephosphorylation (GO:0006470)	0.06738	0.07735	15.98	43.11
282	receptor-mediated endocytosis (GO:0006898)	0.06926	0.07922	15.53	41.47
283	response to cytokine (GO:0034097)	0.07253	0.08239	14.80	38.82
284	regulation of cytokine production (GO:0001817)	0.07253	0.08239	14.80	38.82
285	positive regulation of gene expression (GO:0010628)	0.02295	0.03543	10.16	38.36
286	negative regulation of apoptotic process (GO:0043066)	0.02321	0.03543	10.10	37.99
287	dephosphorylation (GO:0016311)	0.07394	0.08369	14.50	37.77
288	positive regulation of NF-kappaB transcription factor activity (GO:0051092)	0.07487	0.08445	14.31	37.10
289	peptidyl-serine phosphorylation (GO:0018105)	0.07533	0.08469	14.22	36.77
290	cellular response to starvation (GO:0009267)	0.07627	0.08537	14.04	36.12
291	response to lipopolysaccharide (GO:0032496)	0.07673	0.08537	13.95	35.81
292	protein autophosphorylation (GO:0046777)	0.07673	0.08537	13.95	35.81
293	regulation of MAPK cascade (GO:0043408)	0.07998	0.08869	13.35	33.72
294	positive regulation of ERK1 and ERK2 cascade (GO:0070374)	0.08276	0.09146	12.88	32.09
295	positive regulation of intracellular signal transduction (GO:1902533)	0.02895	0.04086	8.94	31.65
296	negative regulation of immune response (GO:0050777)	0.08554	0.09421	12.44	30.58
297	cellular response to tumor necrosis factor (GO:0071356)	0.09289	0.1016	11.40	27.08
298	negative regulation of macromolecule metabolic process (GO:0010605)	0.09289	0.1016	11.40	27.08
299	negative regulation of intracellular signal transduction (GO:1902532)	0.09472	0.1033	11.16	26.31
300	regulation of angiogenesis (GO:0045765)	0.09701	0.1054	10.88	25.39
301	regulation of inflammatory response (GO:0050727)	0.09838	0.1065	10.72	24.87
302	negative regulation of multicellular organismal process (GO:0051241)	0.1020	0.1101	10.32	23.55
303	regulation of autophagy (GO:0010506)	0.1097	0.1180	9.55	21.10
304	regulation of ERK1 and ERK2 cascade (GO:0070372)	0.1128	0.1210	9.26	20.20
305	positive regulation of DNA-binding transcription factor activity (GO:0051091)	0.1164	0.1245	8.95	19.26
306	positive regulation of signal transduction (GO:0009967)	0.1191	0.1269	8.74	18.59
307	cellular component assembly (GO:0022607)	0.1231	0.1307	8.43	17.66
308	protein deubiquitination (GO:0016579)	0.1258	0.1331	8.24	17.08
309	positive regulation of MAPK cascade (GO:0043410)	0.1289	0.1360	8.02	16.44
310	protein modification by small protein removal (GO:0070646)	0.1298	0.1365	7.97	16.27
311	MAPK cascade (GO:0000165)	0.1416	0.1484	7.24	14.16
312	cellular response to DNA damage stimulus (GO:0006974)	0.1619	0.1690	6.25	11.39
313	supramolecular fiber organization (GO:0097435)	0.1623	0.1690	6.23	11.34
314	positive regulation of macromolecule metabolic process (GO:0010604)	0.1763	0.1830	5.69	9.87
315	cellular protein metabolic process (GO:0044267)	0.1900	0.1967	5.23	8.68
316	regulation of intracellular signal transduction (GO:1902531)	0.1983	0.2045	4.98	8.06
317	protein phosphorylation (GO:0006468)	0.2221	0.2284	4.38	6.58
318	negative regulation of cellular process (GO:0048523)	0.2496	0.2559	3.82	5.30
319	positive regulation of cellular process (GO:0048522)	0.2721	0.2780	3.45	4.49
320	negative regulation of transcription by RNA polymerase II (GO:0000122)	0.2939	0.2995	3.14	3.85
321	regulation of transcription by RNA polymerase II (GO:0006357)	0.3040	0.3087	2.02	2.40
322	positive regulation of transcription by RNA polymerase II (GO:0045944)	0.3717	0.3763	2.34	2.31
323	negative regulation of transcription, DNA-templated (GO:0045892)	0.3847	0.3883	2.23	2.13
324	cellular protein modification process (GO:0006464)	0.4092	0.4117	2.06	1.84
325	regulation of gene expression (GO:0010468)	0.4258	0.4271	1.95	1.66
326	positive regulation of transcription, DNA-templated (GO:0045893)	0.4566	0.4566	1.77	1.39

GO: Molecular Function

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	IgG binding (GO:0019864)	0.002498	0.01298	555.17	3326.77
2	acid phosphatase activity (GO:0003993)	0.002997	0.01298	444.11	2580.41
3	interleukin-12 receptor binding (GO:0005143)	0.002997	0.01298	444.11	2580.41
4	non-membrane spanning protein tyrosine phosphatase activity (GO:0004726)	0.002997	0.01298	444.11	2580.41
5	ferric iron binding (GO:0008199)	0.003495	0.01298	370.07	2093.27
6	tumor necrosis factor-activated receptor activity (GO:0005031)	0.004492	0.01460	277.53	1500.17
7	death domain binding (GO:0070513)	0.005488	0.01556	222.00	1155.57
8	death receptor activity (GO:0005035)	0.005985	0.01556	201.81	1032.95
9	death receptor binding (GO:0005123)	0.007476	0.01573	158.54	776.21
10	MHC class II protein complex binding (GO:0023026)	0.008469	0.01573	138.71	661.82
11	phosphatase activity (GO:0016791)	0.0006791	0.01094	64.65	471.62
12	ferrous iron binding (GO:0008198)	0.01194	0.02069	96.46	427.12
13	cytokine receptor activity (GO:0004896)	0.0008418	0.01094	57.86	409.65
14	tumor necrosis factor receptor superfamily binding (GO:0032813)	0.01392	0.02261	82.15	351.18
15	phosphoric ester hydrolase activity (GO:0042578)	0.02619	0.03651	42.60	155.17
16	iron ion binding (GO:0005506)	0.02668	0.03651	41.80	151.46
17	SH3 domain binding (GO:0017124)	0.03058	0.03975	36.30	126.60
18	protein tyrosine phosphatase activity (GO:0004725)	0.03640	0.04506	30.32	100.44
19	ubiquitin protein ligase binding (GO:0031625)	0.007337	0.01573	18.75	92.16
20	amyloid-beta binding (GO:0001540)	0.03930	0.04644	28.00	90.64
21	ubiquitin-like protein ligase binding (GO:0044389)	0.008273	0.01573	17.60	84.38
22	growth factor receptor binding (GO:0070851)	0.05129	0.05556	21.25	63.11
23	cytokine receptor binding (GO:0005126)	0.05129	0.05556	21.25	63.11
24	kinase binding (GO:0019900)	0.02111	0.03228	10.64	41.04
25	protein serine/threonine kinase activity (GO:0004674)	0.1593	0.1657	6.36	11.69
26	protein homodimerization activity (GO:0042803)	0.2762	0.2762	3.39	4.36

GO: Cellular Component

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	death-inducing signaling complex (GO:0031264)	0.000006290	0.00008806	832.67	9972.50
2	CD95 death-inducing signaling complex (GO:0031265)	0.002498	0.009961	555.17	3326.77
3	integral component of plasma membrane (GO:0005887)	0.00002378	0.0001664	19.21	204.50
4	membrane raft (GO:0045121)	0.002846	0.009961	30.79	180.49
5	cytoplasmic side of plasma membrane (GO:0009898)	0.02717	0.07298	41.02	147.91
6	clathrin-coated vesicle (GO:0030136)	0.03930	0.07298	28.00	90.64
7	plasma membrane raft (GO:0044853)	0.04026	0.07298	27.31	87.73
8	clathrin-coated endocytic vesicle (GO:0045334)	0.04171	0.07298	26.33	83.66
9	endocytic vesicle (GO:0030139)	0.09060	0.1409	11.70	28.10
10	endosome membrane (GO:0010008)	0.1511	0.2116	6.74	12.74
11	cytoplasmic vesicle membrane (GO:0030659)	0.1746	0.2222	5.75	10.03
12	bounding membrane of organelle (GO:0098588)	0.3237	0.3777	2.79	3.15
13	nucleus (GO:0005634)	0.6929	0.7462	0.87	0.32
14	intracellular membrane-bounded organelle (GO:0043231)	0.7770	0.7770	0.71	0.18

Categoryautoimmunity

Long COVID-Autoimmunity-Antinuclear antibody positivity

Autoimmunity- Anti-thyroid peroxidase antibody positivity