Anaphylactic shock -GO

May 19, 2022 Off By admin

Anaphylactic shock (HP:0100845)

GENE ONTOLOGY

GO: Biological Process

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	entry of bacterium into host cell (GO:0035635)	0.000006290	0.0001510	832.67	9972.50
2	positive regulation of intracellular signal transduction (GO:1902533)	7.703e-14	2.403e-11	326.03	9844.29
3	positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068)	1.840e-10	2.870e-8	276.64	6201.20
4	epidermal growth factor receptor signaling pathway (GO:0007173)	5.561e-9	3.470e-7	309.26	5878.15
5	embryonic hemopoiesis (GO:0035162)	0.00001750	0.0003211	454.07	4973.59
6	entry into host (GO:0044409)	0.00001750	0.0003211	454.07	4973.59
7	regulation of phospholipase C activity (GO:1900274)	0.00002354	0.0003866	384.17	4094.01
8	regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)	9.380e-10	9.755e-8	196.92	4093.45
9	ERBB signaling pathway (GO:0038127)	2.237e-8	8.724e-7	214.28	3774.65
10	positive regulation of smooth muscle cell differentiation (GO:0051152)	0.002498	0.009061	555.17	3326.77
11	regulation of miRNA metabolic process (GO:2000628)	0.002498	0.009061	555.17	3326.77
12	positive regulation of leukocyte mediated immunity (GO:0002705)	0.002498	0.009061	555.17	3326.77
13	immature B cell differentiation (GO:0002327)	0.002498	0.009061	555.17	3326.77
14	regulation of dendritic cell cytokine production (GO:0002730)	0.002498	0.009061	555.17	3326.77
15	cellular response to erythropoietin (GO:0036018)	0.002498	0.009061	555.17	3326.77
16	interleukin-6-mediated signaling pathway (GO:0070102)	0.00003428	0.0005347	312.09	3208.63
17	regulation of focal adhesion disassembly (GO:0120182)	0.002997	0.01050	444.11	2580.41
18	megakaryocyte development (GO:0035855)	0.002997	0.01050	444.11	2580.41
19	positive regulation of focal adhesion disassembly (GO:0120183)	0.002997	0.01050	444.11	2580.41
20	positive regulation of protein kinase B signaling (GO:0051897)	7.747e-9	4.028e-7	127.14	2374.48
21	positive regulation of phospholipase activity (GO:0010518)	0.00006174	0.0008755	226.91	2199.35
22	regulation of vascular associated smooth muscle cell differentiation (GO:1905063)	0.003495	0.01160	370.07	2093.27
23	positive regulation of vascular associated smooth muscle cell differentiation (GO:1905065)	0.003495	0.01160	370.07	2093.27
24	positive regulation of miRNA metabolic process (GO:2000630)	0.003495	0.01160	370.07	2093.27
25	positive regulation of glucose import (GO:0046326)	0.00007266	0.0009446	207.98	1981.99
26	MAPK cascade (GO:0000165)	2.296e-9	1.791e-7	99.46	1978.44
27	cellular response to interleukin-6 (GO:0071354)	0.00008446	0.001054	191.96	1800.45
28	mast cell activation involved in immune response (GO:0002279)	0.003994	0.01285	317.19	1751.86
29	mast cell degranulation (GO:0043303)	0.003994	0.01285	317.19	1751.86
30	positive regulation of dendritic cell cytokine production (GO:0002732)	0.003994	0.01285	317.19	1751.86
31	regulation of protein kinase B signaling (GO:0051896)	2.734e-8	9.477e-7	97.96	1705.98
32	positive regulation of small GTPase mediated signal transduction (GO:0051057)	0.00009715	0.001123	178.23	1646.74
33	regulation of type I interferon-mediated signaling pathway (GO:0060338)	0.00009715	0.001123	178.23	1646.74
34	ERBB2 signaling pathway (GO:0038128)	0.0001107	0.001191	166.33	1515.06
35	positive regulation of glucose transmembrane transport (GO:0010828)	0.0001107	0.001191	166.33	1515.06
36	mast cell mediated immunity (GO:0002448)	0.004492	0.01401	277.53	1500.17
37	bone cell development (GO:0098751)	0.004492	0.01401	277.53	1500.17
38	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	0.004492	0.01401	277.53	1500.17
39	fibroblast growth factor receptor signaling pathway (GO:0008543)	0.000005964	0.0001510	118.56	1426.25
40	peptidyl-tyrosine dephosphorylation (GO:0035335)	0.0001327	0.001294	151.19	1349.73
41	regulation of phosphatidylinositol 3-kinase activity (GO:0043551)	0.0001327	0.001294	151.19	1349.73
42	transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	1.284e-8	5.722e-7	73.84	1341.72
43	regulation of endoplasmic reticulum unfolded protein response (GO:1900101)	0.004990	0.01535	246.68	1307.49
44	regulation of glucose import (GO:0046324)	0.0001485	0.001404	142.54	1256.48
45	regulation of lipid kinase activity (GO:0043550)	0.005488	0.01631	222.00	1155.57
46	insulin-like growth factor receptor signaling pathway (GO:0048009)	0.005488	0.01631	222.00	1155.57
47	negative regulation of ERBB signaling pathway (GO:1901185)	0.0001737	0.001594	131.26	1136.48
48	cellular response to fibroblast growth factor stimulus (GO:0044344)	0.00001104	0.0002461	95.83	1093.80
49	cellular response to cytokine stimulus (GO:0071345)	3.675e-8	0.000001147	61.49	1052.72
50	positive regulation of phospholipase C activity (GO:0010863)	0.0002010	0.001608	121.64	1035.45
51	male gonad development (GO:0008584)	0.0002010	0.001608	121.64	1035.45
52	development of primary male sexual characteristics (GO:0046546)	0.0002010	0.001608	121.64	1035.45
53	epithelial cell-cell adhesion (GO:0090136)	0.005985	0.01682	201.81	1032.95
54	cellular response to growth hormone stimulus (GO:0071378)	0.005985	0.01682	201.81	1032.95
55	megakaryocyte differentiation (GO:0030219)	0.005985	0.01682	201.81	1032.95
56	melanocyte differentiation (GO:0030318)	0.005985	0.01682	201.81	1032.95
57	positive regulation of endoplasmic reticulum unfolded protein response (GO:1900103)	0.005985	0.01682	201.81	1032.95
58	digestive system development (GO:0055123)	0.005985	0.01682	201.81	1032.95
59	negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)	0.0002105	0.001642	118.74	1005.25
60	positive regulation of RNA metabolic process (GO:0051254)	0.0002202	0.001676	115.97	976.58
61	cellular response to interleukin-15 (GO:0071350)	0.006482	0.01714	184.98	932.06
62	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	0.006482	0.01714	184.98	932.06
63	positive regulation of ruffle assembly (GO:1900029)	0.006482	0.01714	184.98	932.06
64	positive regulation of insulin receptor signaling pathway (GO:0046628)	0.006482	0.01714	184.98	932.06
65	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	0.006482	0.01714	184.98	932.06
66	interleukin-15-mediated signaling pathway (GO:0035723)	0.006482	0.01714	184.98	932.06
67	small GTPase mediated signal transduction (GO:0007264)	0.00001690	0.0003211	82.75	909.24
68	cellular response to ionizing radiation (GO:0071479)	0.0002507	0.001862	108.39	898.70
69	negative regulation of cartilage development (GO:0061037)	0.006979	0.01742	170.74	847.70
70	positive regulation of cellular response to insulin stimulus (GO:1900078)	0.006979	0.01742	170.74	847.70
71	genitalia development (GO:0048806)	0.006979	0.01742	170.74	847.70
72	ovarian follicle development (GO:0001541)	0.006979	0.01742	170.74	847.70
73	immune response-regulating cell surface receptor signaling pathway (GO:0002768)	0.006979	0.01742	170.74	847.70
74	Fc receptor signaling pathway (GO:0038093)	0.00001994	0.0003455	78.17	846.03
75	gonad development (GO:0008406)	0.0002832	0.002015	101.74	831.17
76	negative regulation of chondrocyte differentiation (GO:0032331)	0.007476	0.01822	158.54	776.21
77	neurotrophin TRK receptor signaling pathway (GO:0048011)	0.007476	0.01822	158.54	776.21
78	detection of mechanical stimulus involved in sensory perception (GO:0050974)	0.007476	0.01822	158.54	776.21
79	cytokine-mediated signaling pathway (GO:0019221)	1.652e-7	0.000004685	47.26	737.96
80	peptidyl-tyrosine modification (GO:0018212)	0.0003416	0.002368	92.30	736.71
81	positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081)	0.007973	0.01914	147.96	714.91
82	cellular response to gamma radiation (GO:0071480)	0.008469	0.02017	138.71	661.82
83	actin cytoskeleton reorganization (GO:0031532)	0.0004323	0.002810	81.68	632.69
84	positive regulation of Ras protein signal transduction (GO:0046579)	0.0004323	0.002810	81.68	632.69
85	regulation of innate immune response (GO:0045088)	0.0004462	0.002841	80.35	619.92
86	Ras protein signal transduction (GO:0007265)	0.00004054	0.0006023	61.21	618.98
87	positive regulation of response to endoplasmic reticulum stress (GO:1905898)	0.008966	0.02119	130.54	615.43
88	embryonic organ development (GO:0048568)	0.0004745	0.002961	77.84	595.70
89	regulation of epidermal growth factor receptor signaling pathway (GO:0042058)	0.0004889	0.002991	76.63	584.21
90	positive regulation of actin cytoskeleton reorganization (GO:2000251)	0.009462	0.02220	123.28	574.57
91	peptidyl-tyrosine phosphorylation (GO:0018108)	0.0005185	0.003052	74.34	562.35
92	positive regulation of MAP kinase activity (GO:0043406)	0.0005185	0.003052	74.34	562.35
93	Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)	0.0005489	0.003172	72.18	541.87
94	growth hormone receptor signaling pathway (GO:0060396)	0.009957	0.02301	116.79	538.34
95	myeloid cell development (GO:0061515)	0.009957	0.02301	116.79	538.34
96	Fc-gamma receptor signaling pathway (GO:0038094)	0.0005645	0.003202	71.14	532.12
97	insulin receptor signaling pathway (GO:0008286)	0.0005802	0.003207	70.14	522.67
98	Fc receptor mediated stimulatory signaling pathway (GO:0002431)	0.0005962	0.003207	69.16	513.51
99	regulation of cytokine-mediated signaling pathway (GO:0001959)	0.0005962	0.003207	69.16	513.51
100	neurotrophin signaling pathway (GO:0038179)	0.01045	0.02398	110.94	506.01
101	regulation of MAPK cascade (GO:0043408)	0.00006456	0.0008757	52.13	502.95
102	female gonad development (GO:0008585)	0.01095	0.02493	105.66	476.99
103	negative regulation of GTPase activity (GO:0034260)	0.01144	0.02569	100.85	450.83
104	ephrin receptor signaling pathway (GO:0048013)	0.0007315	0.003868	62.22	449.25
105	positive regulation of plasma membrane bounded cell projection assembly (GO:0120034)	0.0007493	0.003896	61.45	442.20
106	negative regulation of stress fiber assembly (GO:0051497)	0.01194	0.02569	96.46	427.12
107	regulation of ruffle assembly (GO:1900027)	0.01194	0.02569	96.46	427.12
108	positive regulation of cell-substrate junction organization (GO:0150117)	0.01194	0.02569	96.46	427.12
109	positive regulation of protein targeting to membrane (GO:0090314)	0.01194	0.02569	96.46	427.12
110	response to gamma radiation (GO:0010332)	0.01194	0.02569	96.46	427.12
111	positive regulation of lamellipodium assembly (GO:0010592)	0.01194	0.02569	96.46	427.12
112	negative regulation of protein tyrosine kinase activity (GO:0061099)	0.01194	0.02569	96.46	427.12
113	regulation of Ras protein signal transduction (GO:0046578)	0.0008042	0.004113	59.24	422.16
114	positive regulation of ERBB signaling pathway (GO:1901186)	0.01243	0.02657	92.44	405.55
115	regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	0.0009195	0.004627	55.28	386.48
116	negative regulation of signaling receptor activity (GO:2000272)	0.01293	0.02689	88.73	385.85
117	lamellipodium assembly (GO:0030032)	0.01293	0.02689	88.73	385.85
118	positive regulation of filopodium assembly (GO:0051491)	0.01293	0.02689	88.73	385.85
119	regulation of chondrocyte differentiation (GO:0032330)	0.01293	0.02689	88.73	385.85
120	axon guidance (GO:0007411)	0.0001173	0.001220	42.41	383.81
121	hemopoiesis (GO:0030097)	0.0009597	0.004753	54.07	375.73
122	cellular senescence (GO:0090398)	0.01342	0.02737	85.32	367.79
123	regulation of epidermal growth factor-activated receptor activity (GO:0007176)	0.01342	0.02737	85.32	367.79
124	negative regulation of actin filament bundle assembly (GO:0032232)	0.01342	0.02737	85.32	367.79
125	regulation of MAP kinase activity (GO:0043405)	0.001021	0.004979	52.36	360.55
126	positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)	0.01392	0.02764	82.15	351.18
127	positive regulation of protein import into nucleus (GO:0042307)	0.01392	0.02764	82.15	351.18
128	positive regulation of response to wounding (GO:1903036)	0.01392	0.02764	82.15	351.18
129	cellular response to epidermal growth factor stimulus (GO:0071364)	0.01392	0.02764	82.15	351.18
130	positive regulation of protein localization to membrane (GO:1905477)	0.001107	0.005312	50.23	341.88
131	regulation of protein targeting to membrane (GO:0090313)	0.01441	0.02810	79.21	335.86
132	lamellipodium organization (GO:0097581)	0.01441	0.02810	79.21	335.86
133	positive regulation of protein import (GO:1904591)	0.01490	0.02835	76.48	321.69
134	positive regulation of lipid kinase activity (GO:0090218)	0.01490	0.02835	76.48	321.69
135	positive regulation of protein serine/threonine kinase activity (GO:0071902)	0.001218	0.005757	47.80	320.79
136	regulation of ERK1 and ERK2 cascade (GO:0070372)	0.0001877	0.001608	36.03	309.13
137	positive regulation of RNA splicing (GO:0033120)	0.01540	0.02876	73.93	308.54
138	negative regulation of interleukin-6 production (GO:0032715)	0.01540	0.02876	73.93	308.54
139	negative regulation of peptidyl-tyrosine phosphorylation (GO:0050732)	0.01540	0.02876	73.93	308.54
140	axonogenesis (GO:0007409)	0.0001924	0.001608	35.72	305.61
141	regulation of interleukin-6 production (GO:0032675)	0.001311	0.006103	46.02	305.47
142	Fc-epsilon receptor signaling pathway (GO:0038095)	0.001334	0.006122	45.60	301.83
143	positive regulation of receptor signaling pathway via STAT (GO:1904894)	0.01589	0.02916	71.54	296.32
144	hematopoietic progenitor cell differentiation (GO:0002244)	0.01589	0.02916	71.54	296.32
145	positive regulation of lamellipodium organization (GO:1902745)	0.01589	0.02916	71.54	296.32
146	cellular response to lectin (GO:1990858)	0.001431	0.006289	43.98	288.01
147	stimulatory C-type lectin receptor signaling pathway (GO:0002223)	0.001431	0.006289	43.98	288.01
148	positive regulation of receptor signaling pathway via JAK-STAT (GO:0046427)	0.01638	0.02972	69.30	284.93
149	positive regulation of cytokine production involved in immune response (GO:0002720)	0.01638	0.02972	69.30	284.93
150	innate immune response activating cell surface receptor signaling pathway (GO:0002220)	0.001531	0.006635	42.46	275.24
151	regulation of lamellipodium assembly (GO:0010591)	0.01687	0.02974	67.20	274.29
152	positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)	0.01687	0.02974	67.20	274.29
153	regulation of cell adhesion mediated by integrin (GO:0033628)	0.01687	0.02974	67.20	274.29
154	phosphatidylinositol 3-kinase signaling (GO:0014065)	0.01687	0.02974	67.20	274.29
155	cellular response to organic substance (GO:0071310)	0.001635	0.006892	41.05	263.40
156	positive regulation of epithelial cell proliferation (GO:0050679)	0.001635	0.006892	41.05	263.40
157	regulation of tumor necrosis factor production (GO:0032680)	0.001661	0.006910	40.71	260.58
158	regulation of cell cycle G1/S phase transition (GO:1902806)	0.01786	0.03078	63.35	255.00
159	positive regulation of interferon-beta production (GO:0032728)	0.01786	0.03078	63.35	255.00
160	regulation of ossification (GO:0030278)	0.01786	0.03078	63.35	255.00
161	regulation of protein import into nucleus (GO:0042306)	0.01786	0.03078	63.35	255.00
162	positive regulation of MAPK cascade (GO:0043410)	0.0002842	0.002015	31.18	254.65
163	cellular response to insulin stimulus (GO:0032869)	0.001796	0.007372	39.10	247.21
164	lysosome localization (GO:0032418)	0.01835	0.03129	61.59	246.23
165	regulation of actin cytoskeleton reorganization (GO:2000249)	0.01835	0.03129	61.59	246.23
166	positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	0.001936	0.007843	37.61	234.96
167	regulation of receptor-mediated endocytosis (GO:0048259)	0.01933	0.03261	58.34	230.20
168	regulation of cellular component biogenesis (GO:0044087)	0.01933	0.03261	58.34	230.20
169	protein dephosphorylation (GO:0006470)	0.002081	0.008322	36.23	223.71
170	positive regulation of ossification (GO:0045778)	0.01983	0.03273	56.84	222.86
171	stem cell differentiation (GO:0048863)	0.01983	0.03273	56.84	222.86
172	digestive tract development (GO:0048565)	0.01983	0.03273	56.84	222.86
173	positive regulation of wound healing (GO:0090303)	0.01983	0.03273	56.84	222.86
174	epithelial cell migration (GO:0010631)	0.02032	0.03301	55.42	215.92
175	regulation of filopodium assembly (GO:0051489)	0.02032	0.03301	55.42	215.92
176	T cell differentiation (GO:0030217)	0.02032	0.03301	55.42	215.92
177	phosphatidylinositol phosphate biosynthetic process (GO:0046854)	0.02081	0.03364	54.06	209.35
178	positive regulation of intracellular protein transport (GO:0090316)	0.002354	0.009061	33.98	205.63
179	cellular glucose homeostasis (GO:0001678)	0.02130	0.03425	52.77	203.13
180	response to cytokine (GO:0034097)	0.002417	0.009061	33.52	201.95
181	positive regulation of receptor-mediated endocytosis (GO:0048260)	0.02179	0.03486	51.54	197.22
182	regulation of receptor signaling pathway via JAK-STAT (GO:0046425)	0.02228	0.03511	50.37	191.61
183	cellular response to radiation (GO:0071478)	0.02228	0.03511	50.37	191.61
184	regulation of insulin receptor signaling pathway (GO:0046626)	0.02228	0.03511	50.37	191.61
185	erythrocyte differentiation (GO:0030218)	0.02277	0.03530	49.25	186.27
186	positive regulation of nucleocytoplasmic transport (GO:0046824)	0.02277	0.03530	49.25	186.27
187	negative regulation of tumor necrosis factor production (GO:0032720)	0.02277	0.03530	49.25	186.27
188	regulation of wound healing (GO:0061041)	0.02326	0.03540	48.17	181.19
189	negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)	0.02375	0.03545	47.15	176.34
190	substrate adhesion-dependent cell spreading (GO:0034446)	0.02375	0.03545	47.15	176.34
191	positive regulation of endocytosis (GO:0045807)	0.02375	0.03545	47.15	176.34
192	regulation of interferon-beta production (GO:0032648)	0.02424	0.03550	46.16	171.72
193	receptor internalization (GO:0031623)	0.02424	0.03550	46.16	171.72
194	positive regulation of reactive oxygen species metabolic process (GO:2000379)	0.02424	0.03550	46.16	171.72
195	positive regulation of ERK1 and ERK2 cascade (GO:0070374)	0.003162	0.01084	29.15	167.78
196	inositol lipid-mediated signaling (GO:0048017)	0.02521	0.03676	44.31	163.08
197	signal transduction in response to DNA damage (GO:0042770)	0.02570	0.03679	43.44	159.04
198	positive regulation of protein localization to cell periphery (GO:1904377)	0.02570	0.03679	43.44	159.04
199	positive regulation of protein localization to plasma membrane (GO:1903078)	0.02570	0.03679	43.44	159.04
200	myeloid cell differentiation (GO:0030099)	0.02570	0.03679	43.44	159.04
201	regulation of reactive oxygen species metabolic process (GO:2000377)	0.02814	0.04009	39.55	141.22
202	receptor metabolic process (GO:0043112)	0.02863	0.04042	38.86	138.07
203	negative regulation of hydrolase activity (GO:0051346)	0.02863	0.04042	38.86	138.07
204	positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	0.02912	0.04092	38.18	135.03
205	regulation of cell population proliferation (GO:0042127)	0.0003690	0.002502	16.87	133.34
206	B cell differentiation (GO:0030183)	0.03009	0.04210	36.91	129.31
207	positive regulation of cell motility (GO:2000147)	0.005159	0.01563	22.57	118.87
208	positive regulation of cell population proliferation (GO:0008284)	0.001402	0.006289	17.76	116.69
209	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	0.03301	0.04577	33.54	114.41
210	positive regulation of protein localization to nucleus (GO:1900182)	0.03349	0.04603	33.04	112.22
211	regulation of tyrosine phosphorylation of STAT protein (GO:0042509)	0.03349	0.04603	33.04	112.22
212	cell chemotaxis (GO:0060326)	0.03398	0.04649	32.55	110.09
213	regulation of G1/S transition of mitotic cell cycle (GO:2000045)	0.03495	0.04720	31.62	106.05
214	phosphatidylinositol-mediated signaling (GO:0048015)	0.03495	0.04720	31.62	106.05
215	myeloid leukocyte differentiation (GO:0002573)	0.03495	0.04720	31.62	106.05
216	membrane organization (GO:0061024)	0.006154	0.01714	20.57	104.73
217	response to ionizing radiation (GO:0010212)	0.03543	0.04744	31.17	104.12
218	cell morphogenesis involved in differentiation (GO:0000904)	0.03543	0.04744	31.17	104.12
219	positive regulation of JNK cascade (GO:0046330)	0.03591	0.04789	30.74	102.25
220	regulation of stress fiber assembly (GO:0051492)	0.03640	0.04832	30.32	100.44
221	positive regulation of signal transduction (GO:0009967)	0.006657	0.01742	19.74	98.94
222	regulation of hematopoietic progenitor cell differentiation (GO:1901532)	0.03688	0.04876	29.90	98.68
223	positive regulation of phosphorylation (GO:0042327)	0.006708	0.01742	19.66	98.39
224	regulation of RNA splicing (GO:0043484)	0.03736	0.04898	29.50	96.98
225	positive regulation of interleukin-6 production (GO:0032755)	0.03736	0.04898	29.50	96.98
226	positive regulation of endothelial cell proliferation (GO:0001938)	0.03785	0.04900	29.11	95.32
227	positive regulation of tumor necrosis factor production (GO:0032760)	0.03785	0.04900	29.11	95.32
228	positive regulation of type I interferon production (GO:0032481)	0.03785	0.04900	29.11	95.32
229	regulation of protein localization to plasma membrane (GO:1903076)	0.03930	0.05066	28.00	90.64
230	positive regulation of cell migration (GO:0030335)	0.007553	0.01827	18.47	90.23
231	positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)	0.03978	0.05107	27.65	89.16
232	positive regulation of cytoskeleton organization (GO:0051495)	0.04026	0.05148	27.31	87.73
233	lymphocyte differentiation (GO:0030098)	0.04122	0.05228	26.65	84.98
234	response to insulin (GO:0032868)	0.04122	0.05228	26.65	84.98
235	B cell activation (GO:0042113)	0.04171	0.05268	26.33	83.66
236	glucose homeostasis (GO:0042593)	0.04219	0.05307	26.02	82.37
237	transforming growth factor beta receptor signaling pathway (GO:0007179)	0.04363	0.05467	25.13	78.70
238	positive regulation of cellular process (GO:0048522)	0.003092	0.01072	13.34	77.12
239	sensory perception of sound (GO:0007605)	0.04459	0.05565	24.57	76.41
240	T cell activation (GO:0042110)	0.04507	0.05580	24.30	75.31
241	regulation of endothelial cell proliferation (GO:0001936)	0.04507	0.05580	24.30	75.31
242	regulation of epithelial cell proliferation (GO:0050678)	0.04555	0.05617	24.03	74.23
243	regulation of kinase activity (GO:0043549)	0.04603	0.05654	23.77	73.18
244	positive regulation of stress-activated MAPK cascade (GO:0032874)	0.04842	0.05925	22.55	68.29
245	positive regulation of cellular metabolic process (GO:0031325)	0.05129	0.06226	21.25	63.11
246	regulation of JNK cascade (GO:0046328)	0.05129	0.06226	21.25	63.11
247	cellular response to peptide hormone stimulus (GO:0071375)	0.05176	0.06260	21.04	62.31
248	response to endoplasmic reticulum stress (GO:0034976)	0.05367	0.06465	20.27	59.28
249	regulation of apoptotic process (GO:0042981)	0.005019	0.01535	11.16	59.11
250	phosphatidylinositol metabolic process (GO:0046488)	0.05462	0.06555	19.90	57.85
251	positive regulation of protein phosphorylation (GO:0001934)	0.01400	0.02764	13.29	56.75
252	cellular response to transforming growth factor beta stimulus (GO:0071560)	0.05557	0.06618	19.54	56.49
253	positive regulation of kinase activity (GO:0033674)	0.05557	0.06618	19.54	56.49
254	regulation of protein-containing complex assembly (GO:0043254)	0.05652	0.06705	19.20	55.17
255	negative regulation of cell population proliferation (GO:0008285)	0.01457	0.02824	13.01	55.00
256	negative regulation of programmed cell death (GO:0043069)	0.01472	0.02835	12.94	54.57
257	circulatory system development (GO:0072359)	0.06126	0.07212	17.66	49.31
258	phosphatidylinositol biosynthetic process (GO:0006661)	0.06126	0.07212	17.66	49.31
259	regulation of cell migration (GO:0030334)	0.01676	0.02974	12.06	49.30
260	transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178)	0.06456	0.07544	16.72	45.80
261	regulation of cell adhesion (GO:0030155)	0.06456	0.07544	16.72	45.80
262	regulation of cellular component organization (GO:0051128)	0.06738	0.07844	15.98	43.11
263	enzyme linked receptor protein signaling pathway (GO:0007167)	0.06785	0.07870	15.87	42.69
264	receptor-mediated endocytosis (GO:0006898)	0.06926	0.08003	15.53	41.47
265	positive regulation of transferase activity (GO:0051347)	0.07160	0.08243	15.00	39.55
266	positive regulation of hydrolase activity (GO:0051345)	0.07207	0.08266	14.90	39.18
267	brain development (GO:0007420)	0.07253	0.08283	14.80	38.82
268	neutrophil degranulation (GO:0043312)	0.02286	0.03530	10.18	38.48
269	negative regulation of protein phosphorylation (GO:0001933)	0.07347	0.08335	14.60	38.11
270	negative regulation of apoptotic process (GO:0043066)	0.02321	0.03540	10.10	37.99
271	neutrophil activation involved in immune response (GO:0002283)	0.02321	0.03540	10.10	37.99
272	dephosphorylation (GO:0016311)	0.07394	0.08358	14.50	37.77
273	neutrophil mediated immunity (GO:0002446)	0.02348	0.03545	10.03	37.64
274	protein phosphorylation (GO:0006468)	0.02421	0.03550	9.87	36.71
275	cellular response to growth factor stimulus (GO:0071363)	0.07627	0.08559	14.04	36.12
276	T cell receptor signaling pathway (GO:0050852)	0.07627	0.08559	14.04	36.12
277	protein autophosphorylation (GO:0046777)	0.07673	0.08581	13.95	35.81
278	heart development (GO:0007507)	0.07906	0.08809	13.52	34.30
279	glycerophospholipid biosynthetic process (GO:0046474)	0.08508	0.09446	12.51	30.82
280	protein stabilization (GO:0050821)	0.08600	0.09515	12.37	30.34
281	negative regulation of cellular process (GO:0048523)	0.03095	0.04311	8.61	29.93
282	negative regulation of cytokine production (GO:0001818)	0.08738	0.09634	12.16	29.64
283	antigen receptor-mediated signaling pathway (GO:0050851)	0.08876	0.09740	11.96	28.97
284	regulation of mitotic cell cycle phase transition (GO:1901990)	0.09014	0.09834	11.77	28.31
285	regulation of GTPase activity (GO:0043087)	0.09060	0.09849	11.70	28.10
286	negative regulation of cell differentiation (GO:0045596)	0.09152	0.09914	11.58	27.69
287	negative regulation of macromolecule metabolic process (GO:0010605)	0.09289	0.09994	11.40	27.08
288	regulation of programmed cell death (GO:0043067)	0.09289	0.09994	11.40	27.08
289	modification-dependent protein catabolic process (GO:0019941)	0.09609	0.1030	10.99	25.75
290	positive regulation of protein modification process (GO:0031401)	0.1020	0.1086	10.32	23.55
291	positive regulation of GTPase activity (GO:0043547)	0.1020	0.1086	10.32	23.55
292	inflammatory response (GO:0006954)	0.1093	0.1159	9.59	21.23
293	positive regulation of DNA-binding transcription factor activity (GO:0051091)	0.1164	0.1227	8.95	19.26
294	positive regulation of cell differentiation (GO:0045597)	0.1218	0.1279	8.53	17.96
295	regulation of protein phosphorylation (GO:0001932)	0.1253	0.1312	8.27	17.18
296	central nervous system development (GO:0007417)	0.1262	0.1317	8.21	16.99
297	plasma membrane bounded cell projection assembly (GO:0120031)	0.1306	0.1359	7.91	16.09
298	regulation of cell cycle (GO:0051726)	0.1386	0.1436	7.42	14.66
299	positive regulation of transcription by RNA polymerase II (GO:0045944)	0.07274	0.08283	5.27	13.80
300	negative regulation of gene expression (GO:0010629)	0.1499	0.1548	6.81	12.92
301	positive regulation of cytokine production (GO:0001819)	0.1555	0.1601	6.54	12.17
302	positive regulation of multicellular organismal process (GO:0051240)	0.1597	0.1639	6.35	11.64
303	cellular response to DNA damage stimulus (GO:0006974)	0.1619	0.1656	6.25	11.39
304	ubiquitin-dependent protein catabolic process (GO:0006511)	0.1636	0.1668	6.18	11.19
305	protein modification by small protein conjugation (GO:0032446)	0.1867	0.1897	5.33	8.95
306	positive regulation of transcription, DNA-templated (GO:0045893)	0.1148	0.1214	3.98	8.62
307	regulation of transcription by RNA polymerase II (GO:0006357)	0.08897	0.09740	3.46	8.37
308	positive regulation of gene expression (GO:0010628)	0.2165	0.2193	4.51	6.90
309	protein ubiquitination (GO:0016567)	0.2336	0.2359	4.13	6.00
310	cellular protein modification process (GO:0006464)	0.4092	0.4118	2.06	1.84
311	regulation of gene expression (GO:0010468)	0.4258	0.4271	1.95	1.66
312	regulation of transcription, DNA-templated (GO:0006355)	0.6959	0.6959	0.88	0.32

GO: Molecular Function

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	neurotrophin TRK receptor binding (GO:0005167)	0.000003371	0.00003624	1249.13	15739.23
2	neurotrophin TRKA receptor binding (GO:0005168)	0.000003371	0.00003624	1249.13	15739.23
3	phosphotyrosine residue binding (GO:0001784)	2.064e-9	7.512e-8	403.17	8062.84
4	protein phosphorylated amino acid binding (GO:0045309)	3.494e-9	7.512e-8	350.04	6815.94
5	ErbB-3 class receptor binding (GO:0043125)	0.002498	0.007672	555.17	3326.77
6	ephrin receptor binding (GO:0046875)	0.00004701	0.0004043	262.78	2618.60
7	non-membrane spanning protein tyrosine phosphatase activity (GO:0004726)	0.002997	0.008590	444.11	2580.41
8	signaling receptor complex adaptor activity (GO:0030159)	0.0001651	0.001183	134.82	1174.13
9	transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068)	0.005985	0.01355	201.81	1032.95
10	insulin-like growth factor receptor binding (GO:0005159)	0.006979	0.01442	170.74	847.70
11	receptor tyrosine kinase binding (GO:0030971)	0.0003416	0.002098	92.30	736.71
12	1-phosphatidylinositol-3-kinase regulator activity (GO:0046935)	0.007973	0.01442	147.96	714.91
13	transmembrane receptor protein phosphatase activity (GO:0019198)	0.007973	0.01442	147.96	714.91
14	transmembrane receptor protein tyrosine phosphatase activity (GO:0005001)	0.007973	0.01442	147.96	714.91
15	SH3 domain binding (GO:0017124)	0.0004187	0.002251	83.04	645.92
16	GDP binding (GO:0019003)	0.0004889	0.002331	76.63	584.21
17	phosphatidylinositol 3-kinase regulator activity (GO:0035014)	0.009462	0.01627	123.28	574.57
18	protein tyrosine kinase binding (GO:1990782)	0.0005645	0.002331	71.14	532.12
19	protein tyrosine phosphatase activity (GO:0004725)	0.0005962	0.002331	69.16	513.51
20	epidermal growth factor receptor binding (GO:0005154)	0.01293	0.02059	88.73	385.85
21	GTP binding (GO:0005525)	0.003803	0.01022	26.47	147.52
22	transmembrane receptor protein kinase activity (GO:0019199)	0.02960	0.04243	37.53	132.12
23	transmembrane receptor protein tyrosine kinase activity (GO:0004714)	0.02960	0.04243	37.53	132.12
24	guanyl ribonucleotide binding (GO:0032561)	0.004846	0.01179	23.32	124.30
25	GTPase activity (GO:0003924)	0.004935	0.01179	23.10	122.71
26	kinase binding (GO:0019900)	0.001294	0.004637	18.28	121.54
27	protein kinase binding (GO:0019901)	0.001692	0.005596	16.60	105.96
28	nucleoside-triphosphatase activity (GO:0017111)	0.008048	0.01442	17.86	86.11
29	cytokine receptor activity (GO:0004896)	0.04315	0.05985	25.42	79.89
30	cadherin binding (GO:0045296)	0.01068	0.01766	15.37	69.76
31	growth factor receptor binding (GO:0070851)	0.05129	0.06667	21.25	63.11
32	cytokine receptor binding (GO:0005126)	0.05129	0.06667	21.25	63.11
33	protein tyrosine kinase activity (GO:0004713)	0.05272	0.06667	20.65	60.76
34	phosphatase binding (GO:0019902)	0.05557	0.06827	19.54	56.49
35	protein phosphatase binding (GO:0019903)	0.05984	0.07147	18.09	50.96
36	purine ribonucleoside triphosphate binding (GO:0035639)	0.02102	0.03228	10.66	41.18
37	cytokine activity (GO:0005125)	0.08323	0.09672	12.80	31.83
38	ubiquitin protein ligase activity (GO:0061630)	0.1240	0.1402	8.37	17.46
39	ubiquitin-like protein ligase activity (GO:0061659)	0.1271	0.1402	8.15	16.80
40	receptor ligand activity (GO:0048018)	0.1433	0.1541	7.15	13.88
41	ubiquitin-protein transferase activity (GO:0004842)	0.1796	0.1884	5.57	9.56
42	protein homodimerization activity (GO:0042803)	0.2762	0.2828	3.39	4.36
43	RNA binding (GO:0003723)	0.5177	0.5177	1.47	0.97

GO: Cellular Component

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	phosphatidylinositol 3-kinase complex, class I (GO:0097651)	0.002498	0.03312	555.17	3326.77
2	tertiary granule (GO:0070820)	0.002880	0.03312	30.60	179.00
3	tertiary granule lumen (GO:1904724)	0.02717	0.09534	41.02	147.91
4	filopodium (GO:0030175)	0.02863	0.09534	38.86	138.07
5	specific granule lumen (GO:0035580)	0.03058	0.09534	36.30	126.60
6	glutamatergic synapse (GO:0098978)	0.03398	0.09534	32.55	110.09
7	tertiary granule membrane (GO:0070821)	0.03591	0.09534	30.74	102.25
8	actin-based cell projection (GO:0098858)	0.04074	0.09534	26.98	86.34
9	Golgi membrane (GO:0000139)	0.02206	0.09534	10.38	39.60
10	specific granule (GO:0042581)	0.07720	0.1205	13.86	35.50
11	membrane raft (GO:0045121)	0.07859	0.1205	13.60	34.59
12	endoplasmic reticulum membrane (GO:0005789)	0.04712	0.09534	6.79	20.74
13	cilium (GO:0005929)	0.1124	0.1521	9.30	20.33
14	nucleolus (GO:0005730)	0.04966	0.09534	6.59	19.78
15	nuclear lumen (GO:0031981)	0.05114	0.09534	6.48	19.26
16	bounding membrane of organelle (GO:0098588)	0.05389	0.09534	6.28	18.35
17	secretory granule membrane (GO:0030667)	0.1289	0.1647	8.02	16.44
18	secretory granule lumen (GO:0034774)	0.1473	0.1783	6.94	13.29
19	intracellular non-membrane-bounded organelle (GO:0043232)	0.1107	0.1521	4.07	8.96
20	integral component of plasma membrane (GO:0005887)	0.1613	0.1831	3.19	5.82
21	nucleus (GO:0005634)	0.1672	0.1831	2.31	4.13
22	intracellular membrane-bounded organelle (GO:0043231)	0.2469	0.2581	1.90	2.66
23	intracellular organelle lumen (GO:0070013)	0.3517	0.3517	2.51	2.62

Categoryautoimmunity

Anaphylactic Shock – KEGG Pathway

Antinuclear antibody positivity -KEGG Pathway