Anti-thyroid peroxidase antibody positivity-GO

May 23, 2022 Off By admin

Anti-thyroid peroxidase antibody positivity (HP:0025379) -GO

GO: Biological Process

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	negative regulation of neurotransmitter secretion (GO:0046929)	0.000004719	0.0002463	999.25	12254.80
2	regulation of phospholipase C activity (GO:1900274)	4.082e-8	0.000005327	713.50	12139.53
3	negative regulation of regulated secretory pathway (GO:1903306)	0.000006290	0.0002736	832.67	9972.50
4	Rap protein signal transduction (GO:0032486)	0.00001010	0.0003767	624.44	7182.69
5	positive regulation of integrin activation (GO:0033625)	0.00001235	0.0004028	555.03	6273.06
6	Ras protein signal transduction (GO:0007265)	2.362e-11	6.166e-9	218.98	5358.13
7	microvillus organization (GO:0032528)	0.00002041	0.0004160	416.21	4494.85
8	regulation of integrin activation (GO:0033623)	0.00002354	0.0004160	384.17	4094.01
9	microvillus assembly (GO:0030033)	0.00002354	0.0004160	384.17	4094.01
10	regulation of miRNA metabolic process (GO:2000628)	0.002498	0.01207	555.17	3326.77
11	regulation of synaptic vesicle exocytosis (GO:2000300)	0.00003830	0.0005880	293.72	2987.15
12	positive regulation of cell-cell adhesion mediated by integrin (GO:0033634)	0.002997	0.01372	444.11	2580.41
13	positive regulation of phospholipase activity (GO:0010518)	0.00006174	0.0008057	226.91	2199.35
14	negative regulation of T cell apoptotic process (GO:0070233)	0.003495	0.01546	370.07	2093.27
15	positive regulation of miRNA metabolic process (GO:2000630)	0.003495	0.01546	370.07	2093.27
16	small GTPase mediated signal transduction (GO:0007264)	1.527e-7	0.00001193	129.99	2040.10
17	endothelial cell development (GO:0001885)	0.00007266	0.0008620	207.98	1981.99
18	regulation of cell junction assembly (GO:1901888)	0.00007845	0.0008902	199.65	1887.30
19	positive regulation of adaptive immune response (GO:0002821)	0.003994	0.01737	317.19	1751.86
20	establishment of endothelial barrier (GO:0061028)	0.00009070	0.0009469	184.84	1720.52
21	positive regulation of leukocyte cell-cell adhesion (GO:1903039)	0.0001038	0.0009677	172.08	1578.44
22	cellular response to cAMP (GO:0071320)	0.0001038	0.0009677	172.08	1578.44
23	lipid phosphorylation (GO:0046834)	0.004990	0.01944	246.68	1307.49
24	nerve growth factor signaling pathway (GO:0038180)	0.004990	0.01944	246.68	1307.49
25	regulation of T-helper 17 type immune response (GO:2000316)	0.004990	0.01944	246.68	1307.49
26	regulation of cell-cell adhesion mediated by integrin (GO:0033632)	0.004990	0.01944	246.68	1307.49
27	negative regulation of lymphocyte apoptotic process (GO:0070229)	0.004990	0.01944	246.68	1307.49
28	positive regulation of vasculogenesis (GO:2001214)	0.004990	0.01944	246.68	1307.49
29	response to cAMP (GO:0051591)	0.0001567	0.001319	138.57	1214.06
30	regulation of cellular component biogenesis (GO:0044087)	0.0001651	0.001347	134.82	1174.13
31	regulation of T cell apoptotic process (GO:0070232)	0.005488	0.02046	222.00	1155.57
32	glycerolipid metabolic process (GO:0046486)	0.005488	0.02046	222.00	1155.57
33	regulation of phospholipase activity (GO:0010517)	0.005488	0.02046	222.00	1155.57
34	positive regulation of phospholipase C activity (GO:0010863)	0.0002010	0.001543	121.64	1035.45
35	regulation of leukocyte cell-cell adhesion (GO:1903037)	0.005985	0.02165	201.81	1032.95
36	positive regulation of T-helper 17 type immune response (GO:2000318)	0.005985	0.02165	201.81	1032.95
37	MAPK cascade (GO:0000165)	1.829e-7	0.00001193	66.08	1025.21
38	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824)	0.006482	0.02169	184.98	932.06
39	positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)	0.006482	0.02169	184.98	932.06
40	regulation of homotypic cell-cell adhesion (GO:0034110)	0.006482	0.02169	184.98	932.06
41	positive regulation of ruffle assembly (GO:1900029)	0.006482	0.02169	184.98	932.06
42	positive regulation of vascular endothelial cell proliferation (GO:1905564)	0.006482	0.02169	184.98	932.06
43	regulation of vasculogenesis (GO:2001212)	0.006979	0.02277	170.74	847.70
44	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	0.006979	0.02277	170.74	847.70
45	cellular response to lectin (GO:1990858)	0.00002158	0.0004160	76.06	817.21
46	stimulatory C-type lectin receptor signaling pathway (GO:0002223)	0.00002158	0.0004160	76.06	817.21
47	innate immune response activating cell surface receptor signaling pathway (GO:0002220)	0.00002391	0.0004160	73.43	781.36
48	T cell proliferation (GO:0042098)	0.007476	0.02375	158.54	776.21
49	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	0.007476	0.02375	158.54	776.21
50	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	0.007973	0.02414	147.96	714.91
51	positive regulation of endothelial cell apoptotic process (GO:2000353)	0.007973	0.02414	147.96	714.91
52	regulation of establishment of cell polarity (GO:2000114)	0.007973	0.02414	147.96	714.91
53	cellular response to gamma radiation (GO:0071480)	0.008469	0.02463	138.71	661.82
54	positive regulation of telomere capping (GO:1904355)	0.008469	0.02463	138.71	661.82
55	regulation of cellular component organization (GO:0051128)	0.00003804	0.0005880	62.57	636.72
56	positive regulation of cell adhesion mediated by integrin (GO:0033630)	0.008966	0.02463	130.54	615.43
57	regulation of adaptive immune response (GO:0002819)	0.008966	0.02463	130.54	615.43
58	regulation of vascular endothelial cell proliferation (GO:1905562)	0.008966	0.02463	130.54	615.43
59	positive regulation of interleukin-4 production (GO:0032753)	0.008966	0.02463	130.54	615.43
60	regulation of platelet aggregation (GO:0090330)	0.008966	0.02463	130.54	615.43
61	regulation of establishment or maintenance of cell polarity (GO:0032878)	0.008966	0.02463	130.54	615.43
62	positive regulation of hydrolase activity (GO:0051345)	0.00004680	0.0006786	58.25	580.74
63	negative regulation of T cell receptor signaling pathway (GO:0050860)	0.009462	0.02546	123.28	574.57
64	positive regulation of actin cytoskeleton reorganization (GO:2000251)	0.009462	0.02546	123.28	574.57
65	positive regulation of MAP kinase activity (GO:0043406)	0.0005185	0.003561	74.34	562.35
66	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	0.009957	0.02652	116.79	538.34
67	T cell receptor signaling pathway (GO:0050852)	0.00005573	0.0007656	54.84	537.19
68	positive regulation of JNK cascade (GO:0046330)	0.0005802	0.003883	70.14	522.67
69	neurotrophin signaling pathway (GO:0038179)	0.01045	0.02708	110.94	506.01
70	positive regulation of endothelial cell proliferation (GO:0001938)	0.0006453	0.004211	66.38	487.64
71	positive regulation of ERK1 and ERK2 cascade (GO:0070374)	0.00007175	0.0008620	50.26	479.64
72	cellular response to nerve growth factor stimulus (GO:1990090)	0.01095	0.02708	105.66	476.99
73	regulation of platelet activation (GO:0010543)	0.01095	0.02708	105.66	476.99
74	positive regulation of natural killer cell mediated immunity (GO:0002717)	0.01144	0.02708	100.85	450.83
75	regulation of interleukin-4 production (GO:0032673)	0.01144	0.02708	100.85	450.83
76	regulation of telomere capping (GO:1904353)	0.01144	0.02708	100.85	450.83
77	membrane protein ectodomain proteolysis (GO:0006509)	0.01144	0.02708	100.85	450.83
78	negative regulation of GTPase activity (GO:0034260)	0.01144	0.02708	100.85	450.83
79	positive regulation of epithelial cell apoptotic process (GO:1904037)	0.01144	0.02708	100.85	450.83
80	diacylglycerol metabolic process (GO:0046339)	0.01144	0.02708	100.85	450.83
81	positive regulation of interleukin-17 production (GO:0032740)	0.01144	0.02708	100.85	450.83
82	antigen receptor-mediated signaling pathway (GO:0050851)	0.00008908	0.0009469	46.64	435.00
83	regulation of ruffle assembly (GO:1900027)	0.01194	0.02733	96.46	427.12
84	positive regulation of protein targeting to membrane (GO:0090314)	0.01194	0.02733	96.46	427.12
85	response to gamma radiation (GO:0010332)	0.01194	0.02733	96.46	427.12
86	regulation of GTPase activity (GO:0043087)	0.00009492	0.0009528	45.63	422.66
87	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	0.01243	0.02797	92.44	405.55
88	regulation of heterotypic cell-cell adhesion (GO:0034114)	0.01243	0.02797	92.44	405.55
89	positive regulation of protein phosphorylation (GO:0001934)	0.00002240	0.0004160	35.65	381.65
90	positive regulation of calcium ion transmembrane transport (GO:1904427)	0.01342	0.02944	85.32	367.79
91	cellular senescence (GO:0090398)	0.01342	0.02944	85.32	367.79
92	negative regulation of insulin receptor signaling pathway (GO:0046627)	0.01342	0.02944	85.32	367.79
93	regulation of MAP kinase activity (GO:0043405)	0.001021	0.006502	52.36	360.55
94	positive regulation of protein modification process (GO:0031401)	0.0001371	0.001193	40.17	357.33
95	positive regulation of GTPase activity (GO:0043547)	0.0001371	0.001193	40.17	357.33
96	negative regulation of cellular response to insulin stimulus (GO:1900077)	0.01392	0.02977	82.15	351.18
97	positive regulation of response to wounding (GO:1903036)	0.01392	0.02977	82.15	351.18
98	cellular response to epidermal growth factor stimulus (GO:0071364)	0.01392	0.02977	82.15	351.18
99	positive regulation of stress-activated MAPK cascade (GO:0032874)	0.001064	0.006610	51.27	351.00
100	regulation of protein targeting to membrane (GO:0090313)	0.01441	0.03033	79.21	335.86
101	cellular response to organonitrogen compound (GO:0071417)	0.001151	0.006983	49.23	333.17
102	regulation of JNK cascade (GO:0046328)	0.001195	0.007064	48.27	324.82
103	positive regulation of small GTPase mediated signal transduction (GO:0051057)	0.01490	0.03063	76.48	321.69
104	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	0.01490	0.03063	76.48	321.69
105	positive regulation of lipid kinase activity (GO:0090218)	0.01490	0.03063	76.48	321.69
106	positive regulation of protein serine/threonine kinase activity (GO:0071902)	0.001218	0.007064	47.80	320.79
107	regulation of ERK1 and ERK2 cascade (GO:0070372)	0.0001877	0.001485	36.03	309.13
108	Fc-epsilon receptor signaling pathway (GO:0038095)	0.001334	0.007542	45.60	301.83
109	Fc receptor signaling pathway (GO:0038093)	0.001358	0.007542	45.18	298.27
110	activation of phospholipase C activity (GO:0007202)	0.01589	0.03190	71.54	296.32
111	B cell proliferation (GO:0042100)	0.01589	0.03190	71.54	296.32
112	positive regulation of telomere maintenance (GO:0032206)	0.01589	0.03190	71.54	296.32
113	regulation of interleukin-17 production (GO:0032660)	0.01638	0.03239	69.30	284.93
114	positive regulation of telomere maintenance via telomerase (GO:0032212)	0.01638	0.03239	69.30	284.93
115	positive regulation of phosphorylation (GO:0042327)	0.0002248	0.001676	33.84	284.27
116	positive regulation of protein-containing complex assembly (GO:0031334)	0.001506	0.007802	42.83	278.34
117	positive regulation of calcium ion transport into cytosol (GO:0010524)	0.01687	0.03262	67.20	274.29
118	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	0.01687	0.03262	67.20	274.29
119	positive regulation of telomerase activity (GO:0051973)	0.01687	0.03262	67.20	274.29
120	regulation of protein phosphorylation (GO:0001932)	0.0002605	0.001889	32.15	265.30
121	regulation of T cell receptor signaling pathway (GO:0050856)	0.01737	0.03309	65.22	264.33
122	positive regulation of lymphocyte activation (GO:0051251)	0.01737	0.03309	65.22	264.33
123	positive regulation of epithelial cell proliferation (GO:0050679)	0.001635	0.008204	41.05	263.40
124	positive regulation of telomere maintenance via telomere lengthening (GO:1904358)	0.01786	0.03378	63.35	255.00
125	positive regulation of MAPK cascade (GO:0043410)	0.0002842	0.002005	31.18	254.65
126	regulation of actin cytoskeleton reorganization (GO:2000249)	0.01835	0.03421	61.59	246.23
127	regulation of p38MAPK cascade (GO:1900744)	0.01835	0.03421	61.59	246.23
128	lymphocyte proliferation (GO:0046651)	0.01884	0.03488	59.92	237.98
129	membrane protein proteolysis (GO:0033619)	0.01933	0.03554	58.34	230.20
130	positive regulation of wound healing (GO:0090303)	0.01983	0.03618	56.84	222.86
131	acylglycerol metabolic process (GO:0006639)	0.02032	0.03682	55.42	215.92
132	lipid modification (GO:0030258)	0.02130	0.03756	52.77	203.13
133	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	0.02130	0.03756	52.77	203.13
134	natural killer cell activation (GO:0030101)	0.02130	0.03756	52.77	203.13
135	cellular response to organic cyclic compound (GO:0071407)	0.002417	0.01190	33.52	201.95
136	positive regulation of cell-matrix adhesion (GO:0001954)	0.02179	0.03756	51.54	197.22
137	regulation of endothelial cell apoptotic process (GO:2000351)	0.02179	0.03756	51.54	197.22
138	regulation of insulin receptor signaling pathway (GO:0046626)	0.02228	0.03756	50.37	191.61
139	positive regulation of RNA metabolic process (GO:0051254)	0.02228	0.03756	50.37	191.61
140	cellular response to growth factor stimulus (GO:0071363)	0.002677	0.01270	31.79	188.27
141	regulation of synaptic transmission, glutamatergic (GO:0051966)	0.02277	0.03756	49.25	186.27
142	regulation of telomerase activity (GO:0051972)	0.02277	0.03756	49.25	186.27
143	interleukin-12-mediated signaling pathway (GO:0035722)	0.02277	0.03756	49.25	186.27
144	epidermal growth factor receptor signaling pathway (GO:0007173)	0.02326	0.03756	48.17	181.19
145	positive regulation of cell-cell adhesion (GO:0022409)	0.02326	0.03756	48.17	181.19
146	regulation of T cell activation (GO:0050863)	0.02326	0.03756	48.17	181.19
147	regulation of wound healing (GO:0061041)	0.02326	0.03756	48.17	181.19
148	polyol metabolic process (GO:0019751)	0.02326	0.03756	48.17	181.19
149	cellular response to interleukin-12 (GO:0071349)	0.02375	0.03756	47.15	176.34
150	cellular response to ionizing radiation (GO:0071479)	0.02375	0.03756	47.15	176.34
151	positive regulation of blood vessel endothelial cell migration (GO:0043536)	0.02375	0.03756	47.15	176.34
152	phosphatidic acid biosynthetic process (GO:0006654)	0.02375	0.03756	47.15	176.34
153	inositol phosphate metabolic process (GO:0043647)	0.02375	0.03756	47.15	176.34
154	regulation of MAPK cascade (GO:0043408)	0.002950	0.01372	30.22	176.08
155	regulation of stress-activated MAPK cascade (GO:0032872)	0.02424	0.03811	46.16	171.72
156	phosphatidic acid metabolic process (GO:0046473)	0.02473	0.03864	45.22	167.30
157	regulation of epithelial cell migration (GO:0010632)	0.02521	0.03917	44.31	163.08
158	regulation of release of sequestered calcium ion into cytosol (GO:0051279)	0.02570	0.03946	43.44	159.04
159	regulation of telomere maintenance via telomerase (GO:0032210)	0.02570	0.03946	43.44	159.04
160	regulation of megakaryocyte differentiation (GO:0045652)	0.02668	0.04072	41.80	151.46
161	regulation of blood vessel endothelial cell migration (GO:0043535)	0.02717	0.04123	41.02	147.91
162	positive regulation of interferon-gamma production (GO:0032729)	0.02814	0.04246	39.55	141.22
163	negative regulation of hydrolase activity (GO:0051346)	0.02863	0.04295	38.86	138.07
164	axon guidance (GO:0007411)	0.004372	0.01871	24.61	133.71
165	positive regulation of DNA biosynthetic process (GO:2000573)	0.03009	0.04488	36.91	129.31
166	positive regulation of Ras protein signal transduction (GO:0046579)	0.03106	0.04607	35.71	123.99
167	regulation of cell-matrix adhesion (GO:0001952)	0.03204	0.04724	34.59	119.03
168	ERBB signaling pathway (GO:0038127)	0.03252	0.04769	34.06	116.68
169	neutrophil degranulation (GO:0043312)	0.001462	0.007802	17.49	114.20
170	neutrophil activation involved in immune response (GO:0002283)	0.001498	0.007802	17.35	112.81
171	regulation of myeloid cell differentiation (GO:0045637)	0.03349	0.04883	33.04	112.22
172	neutrophil mediated immunity (GO:0002446)	0.001524	0.007802	17.24	111.79
173	cell chemotaxis (GO:0060326)	0.03398	0.04927	32.55	110.09
174	positive regulation of cell-substrate adhesion (GO:0010811)	0.03446	0.04969	32.08	108.04
175	Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)	0.03495	0.05011	31.62	106.05
176	axonogenesis (GO:0007409)	0.006056	0.02165	20.75	105.95
177	Fc-gamma receptor signaling pathway (GO:0038094)	0.03543	0.05053	31.17	104.12
178	Fc receptor mediated stimulatory signaling pathway (GO:0002431)	0.03640	0.05135	30.32	100.44
179	regulation of peptide hormone secretion (GO:0090276)	0.03640	0.05135	30.32	100.44
180	positive regulation of T cell activation (GO:0050870)	0.03688	0.05148	29.90	98.68
181	positive regulation of immune response (GO:0050778)	0.03688	0.05148	29.90	98.68
182	positive regulation of tumor necrosis factor production (GO:0032760)	0.03785	0.05227	29.11	95.32
183	glycerophospholipid metabolic process (GO:0006650)	0.03930	0.05398	28.00	90.64
184	positive regulation of cell migration (GO:0030335)	0.007553	0.02375	18.47	90.23
185	positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)	0.03978	0.05436	27.65	89.16
186	positive regulation of cytoskeleton organization (GO:0051495)	0.04026	0.05445	27.31	87.73
187	ephrin receptor signaling pathway (GO:0048013)	0.04026	0.05445	27.31	87.73
188	positive regulation of plasma membrane bounded cell projection assembly (GO:0120034)	0.04074	0.05481	26.98	86.34
189	plasma membrane bounded cell projection assembly (GO:0120031)	0.008048	0.02414	17.86	86.11
190	B cell activation (GO:0042113)	0.04171	0.05561	26.33	83.66
191	regulation of Ras protein signal transduction (GO:0046578)	0.04219	0.05561	26.02	82.37
192	regulation of interferon-gamma production (GO:0032649)	0.04219	0.05561	26.02	82.37
193	positive regulation of endothelial cell migration (GO:0010595)	0.04219	0.05561	26.02	82.37
194	positive regulation of neuron projection development (GO:0010976)	0.04315	0.05659	25.42	79.89
195	second-messenger-mediated signaling (GO:0019932)	0.04363	0.05694	25.13	78.70
196	T cell activation (GO:0042110)	0.04507	0.05823	24.30	75.31
197	regulation of endothelial cell proliferation (GO:0001936)	0.04507	0.05823	24.30	75.31
198	regulation of epithelial cell proliferation (GO:0050678)	0.04555	0.05856	24.03	74.23
199	positive regulation of epithelial cell migration (GO:0010634)	0.04603	0.05889	23.77	73.18
200	cellular response to oxygen-containing compound (GO:1901701)	0.01074	0.02708	15.32	69.45
201	positive regulation of protein localization to membrane (GO:1905477)	0.04938	0.06286	22.10	66.48
202	positive regulation of cytokine production (GO:0001819)	0.01152	0.02708	14.76	65.88
203	calcium-mediated signaling (GO:0019722)	0.04986	0.06286	21.88	65.61
204	positive regulation of vasculature development (GO:1904018)	0.04986	0.06286	21.88	65.61
205	regulation of insulin secretion (GO:0050796)	0.05081	0.06376	21.45	63.92
206	activation of GTPase activity (GO:0090630)	0.05129	0.06405	21.25	63.11
207	modulation of chemical synaptic transmission (GO:0050804)	0.05319	0.06607	20.45	60.01
208	regulation of protein kinase activity (GO:0045859)	0.05367	0.06607	20.27	59.28
209	phosphatidylinositol metabolic process (GO:0046488)	0.05462	0.06693	19.90	57.85
210	positive regulation of kinase activity (GO:0033674)	0.05557	0.06778	19.54	56.49
211	positive regulation of protein metabolic process (GO:0051247)	0.05605	0.06804	19.37	55.82
212	positive regulation of angiogenesis (GO:0045766)	0.05652	0.06830	19.20	55.17
213	positive regulation of cell projection organization (GO:0031346)	0.05700	0.06855	19.04	54.53
214	regulation of tumor necrosis factor production (GO:0032680)	0.06031	0.07221	17.95	50.40
215	regulation of protein secretion (GO:0050708)	0.06078	0.07244	17.80	49.85
216	protein localization to plasma membrane (GO:0072659)	0.06597	0.07791	16.34	44.43
217	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	0.06597	0.07791	16.34	44.43
218	regulation of inflammatory response to antigenic stimulus (GO:0002861)	0.06644	0.07811	16.22	43.98
219	protein localization to cell periphery (GO:1990778)	0.06785	0.07941	15.87	42.69
220	positive regulation of transferase activity (GO:0051347)	0.07160	0.08305	15.00	39.55
221	positive regulation of intracellular protein transport (GO:0090316)	0.07160	0.08305	15.00	39.55
222	positive regulation of cell population proliferation (GO:0008284)	0.02224	0.03756	10.34	39.35
223	positive regulation of protein kinase activity (GO:0045860)	0.07440	0.08555	14.41	37.43
224	positive regulation of NF-kappaB transcription factor activity (GO:0051092)	0.07487	0.08570	14.31	37.10
225	peptidyl-serine phosphorylation (GO:0018105)	0.07533	0.08586	14.22	36.77
226	regulation of neuron projection development (GO:0010975)	0.07952	0.09024	13.43	34.01
227	peptidyl-serine modification (GO:0018209)	0.08138	0.09194	13.11	32.89
228	regulation of gene expression (GO:0010468)	0.01412	0.02996	7.53	32.09
229	glycerophospholipid biosynthetic process (GO:0046474)	0.08508	0.09571	12.51	30.82
230	negative regulation of immune response (GO:0050777)	0.08554	0.09582	12.44	30.58
231	negative regulation of macromolecule metabolic process (GO:0010605)	0.09289	0.1036	11.40	27.08
232	protein localization to membrane (GO:0072657)	0.09335	0.1037	11.34	26.89
233	positive regulation of cellular process (GO:0048522)	0.03715	0.05158	7.77	25.59
234	regulation of angiogenesis (GO:0045765)	0.09701	0.1073	10.88	25.39
235	negative regulation of inflammatory response (GO:0050728)	0.1011	0.1109	10.42	23.87
236	phosphate-containing compound metabolic process (GO:0006796)	0.1011	0.1109	10.42	23.87
237	regulation of cell growth (GO:0001558)	0.1034	0.1129	10.17	23.08
238	positive regulation of cell motility (GO:2000147)	0.1052	0.1144	9.98	22.49
239	positive regulation of DNA-binding transcription factor activity (GO:0051091)	0.1164	0.1256	8.95	19.26
240	regulation of cell population proliferation (GO:0042127)	0.05351	0.06607	6.31	18.47
241	positive regulation of cell differentiation (GO:0045597)	0.1218	0.1308	8.53	17.96
242	negative regulation of signal transduction (GO:0009968)	0.1258	0.1345	8.24	17.08
243	regulation of cell cycle (GO:0051726)	0.1386	0.1476	7.42	14.66
244	positive regulation of transcription by RNA polymerase II (GO:0045944)	0.07274	0.08401	5.27	13.80
245	negative regulation of gene expression (GO:0010629)	0.1499	0.1590	6.81	12.92
246	negative regulation of cell population proliferation (GO:0008285)	0.1742	0.1840	5.76	10.08
247	positive regulation of macromolecule metabolic process (GO:0010604)	0.1763	0.1855	5.69	9.87
248	phosphorylation (GO:0016310)	0.1830	0.1918	5.46	9.27
249	transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	0.1846	0.1928	5.40	9.12
250	regulation of cell migration (GO:0030334)	0.1863	0.1937	5.35	8.98
251	positive regulation of transcription, DNA-templated (GO:0045893)	0.1148	0.1243	3.98	8.62
252	regulation of nucleic acid-templated transcription (GO:1903506)	0.1954	0.2024	5.07	8.27
253	regulation of cellular macromolecule biosynthetic process (GO:2000112)	0.2109	0.2175	4.65	7.23
254	positive regulation of gene expression (GO:0010628)	0.2165	0.2225	4.51	6.90
255	protein phosphorylation (GO:0006468)	0.2221	0.2273	4.38	6.58
256	positive regulation of nucleic acid-templated transcription (GO:1903508)	0.2281	0.2325	4.24	6.27
257	positive regulation of intracellular signal transduction (GO:1902533)	0.2418	0.2456	3.96	5.63
258	negative regulation of cellular process (GO:0048523)	0.2496	0.2525	3.82	5.30
259	cytokine-mediated signaling pathway (GO:0019221)	0.2706	0.2727	3.47	4.54
260	regulation of transcription by RNA polymerase II (GO:0006357)	0.3040	0.3051	2.02	2.40
261	regulation of transcription, DNA-templated (GO:0006355)	0.3114	0.3114	1.98	2.31

GO: Molecular Function

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	GDP binding (GO:0019003)	9.011e-11	2.433e-9	321.42	7434.41
2	neurotrophin TRK receptor binding (GO:0005167)	0.002997	0.008990	444.11	2580.41
3	neurotrophin TRKA receptor binding (GO:0005168)	0.002997	0.008990	444.11	2580.41
4	GTP binding (GO:0005525)	1.733e-8	2.283e-7	107.64	1923.63
5	guanyl ribonucleotide binding (GO:0032561)	3.229e-8	2.283e-7	94.65	1632.51
6	GTPase activity (GO:0003924)	3.383e-8	2.283e-7	93.74	1612.51
7	diacylglycerol kinase activity (GO:0004143)	0.005488	0.01482	222.00	1155.57
8	nucleoside-triphosphatase activity (GO:0017111)	1.192e-7	6.434e-7	72.22	1151.45
9	protein kinase C activity (GO:0004697)	0.006979	0.01713	170.74	847.70
10	purine ribonucleoside triphosphate binding (GO:0035639)	0.000001443	0.000006493	42.93	577.42
11	phosphatidylinositol phospholipase C activity (GO:0004435)	0.01144	0.02398	100.85	450.83
12	phospholipase C activity (GO:0004629)	0.01243	0.02398	92.44	405.55
13	SH2 domain binding (GO:0042169)	0.01589	0.02860	71.54	296.32
14	guanyl-nucleotide exchange factor activity (GO:0005085)	0.002386	0.008990	33.75	203.77
15	SH3 domain binding (GO:0017124)	0.03058	0.04587	36.30	126.60
16	phosphotransferase activity, alcohol group as acceptor (GO:0016773)	0.03688	0.05241	29.90	98.68
17	GTPase activator activity (GO:0005096)	0.01158	0.02398	14.71	65.59
18	kinase activity (GO:0016301)	0.05462	0.07145	19.90	57.85
19	phosphatase binding (GO:0019902)	0.05557	0.07145	19.54	56.49
20	protein phosphatase binding (GO:0019903)	0.05984	0.07344	18.09	50.96
21	kinase binding (GO:0019900)	0.02111	0.03562	10.64	41.04
22	protein kinase binding (GO:0019901)	0.02513	0.03991	9.67	35.61
23	zinc ion binding (GO:0008270)	0.1559	0.1739	6.52	12.12
24	protein serine/threonine kinase activity (GO:0004674)	0.1593	0.1739	6.36	11.69
25	calcium ion binding (GO:0005509)	0.1610	0.1739	6.29	11.49
26	transition metal ion binding (GO:0046914)	0.2015	0.2093	4.89	7.84
27	metal ion binding (GO:0046872)	0.2305	0.2305	4.19	6.15

GO: Cellular Component

Index	Name	P-value	Adjusted p-value	Odds Ratio	Combined score
1	glutamatergic synapse (GO:0098978)	0.0005185	0.005012	74.34	562.35
2	aggresome (GO:0016235)	0.01737	0.07195	65.22	264.33
3	secretory granule membrane (GO:0030667)	0.0002842	0.005012	31.18	254.65
4	membrane raft (GO:0045121)	0.002846	0.01651	30.79	180.49
5	azurophil granule membrane (GO:0035577)	0.02863	0.1038	38.86	138.07
6	bounding membrane of organelle (GO:0098588)	0.0003745	0.005012	16.80	132.55
7	Golgi membrane (GO:0000139)	0.001385	0.01004	17.84	117.41
8	tertiary granule membrane (GO:0070821)	0.03591	0.1061	30.74	102.25
9	lipid droplet (GO:0005811)	0.03785	0.1061	29.11	95.32
10	plasma membrane raft (GO:0044853)	0.04026	0.1061	27.31	87.73
11	specific granule membrane (GO:0035579)	0.04459	0.1078	24.57	76.41
12	endoplasmic reticulum membrane (GO:0005789)	0.004470	0.02160	11.65	63.06
13	mitochondrial outer membrane (GO:0005741)	0.06126	0.1349	17.66	49.31
14	organelle outer membrane (GO:0031968)	0.06879	0.1349	15.64	41.87
15	azurophil granule (GO:0042582)	0.07487	0.1349	14.31	37.10
16	specific granule (GO:0042581)	0.07720	0.1349	13.86	35.50
17	tertiary granule (GO:0070820)	0.07906	0.1349	13.52	34.30
18	late endosome (GO:0005770)	0.09060	0.1460	11.70	28.10
19	early endosome (GO:0005769)	0.1253	0.1850	8.27	17.18
20	cell-cell junction (GO:0005911)	0.1276	0.1850	8.12	16.71
21	endosome membrane (GO:0010008)	0.1511	0.2021	6.74	12.74
22	lysosomal membrane (GO:0005765)	0.1533	0.2021	6.64	12.45
23	cytoplasmic vesicle membrane (GO:0030659)	0.1746	0.2093	5.75	10.03
24	focal adhesion (GO:0005925)	0.1775	0.2093	5.64	9.75
25	cell-substrate junction (GO:0030055)	0.1805	0.2093	5.54	9.49
26	mitochondrial membrane (GO:0031966)	0.2113	0.2357	4.63	7.21
27	intracellular non-membrane-bounded organelle (GO:0043232)	0.4493	0.4826	1.81	1.45
28	nucleus (GO:0005634)	0.9211	0.9505	0.38	0.03
29	intracellular membrane-bounded organelle (GO:0043231)	0.9505	0.9505	0.32	0.02

Categoryautoimmunity

Anti-thyroid peroxidase antibody positivity-KEGG Pathway

Autoimmunity- Anti-thyroglobulin antibody positivity