Spasticity (HP:0001257)
A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes.
Synonyms: Involuntary muscle stiffness, contraction, or spasm, Muscle spasticity, Muscular spasticity
Cross References: MSH:D009128, SNOMEDCT_US:221360009, SNOMEDCT_US:397790002, UMLS:C0026838
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Lysosome | 0.00002973 | 0.0003271 | 68.11 | 709.91 |
| 2 | Non-small cell lung cancer | 0.03543 | 0.07795 | 31.17 | 104.12 |
| 3 | Endocytosis | 0.006657 | 0.03661 | 19.74 | 98.94 |
| 4 | Amyotrophic lateral sclerosis | 0.01350 | 0.04949 | 13.56 | 58.36 |
| 5 | Dopaminergic synapse | 0.06409 | 0.1175 | 16.84 | 46.28 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | synaptic vesicle transport (GO:0048489) | 0.00001235 | 0.0002012 | 555.03 | 6273.06 |
| 2 | synaptic vesicle localization (GO:0097479) | 0.00001750 | 0.0002012 | 454.07 | 4973.59 |
| 3 | anterograde dendritic transport (GO:0098937) | 0.002498 | 0.01413 | 555.17 | 3326.77 |
| 4 | anterograde dendritic transport of neurotransmitter receptor complex (GO:0098971) | 0.002498 | 0.01413 | 555.17 | 3326.77 |
| 5 | establishment of vesicle localization (GO:0051650) | 0.00003428 | 0.0002628 | 312.09 | 3208.63 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | olfactory receptor binding (GO:0031849) | 0.002997 | 0.01512 | 444.11 | 2580.41 |
| 2 | CD4 receptor binding (GO:0042609) | 0.003994 | 0.01512 | 317.19 | 1751.86 |
| 3 | microtubule motor activity (GO:0003777) | 0.02766 | 0.04336 | 40.27 | 144.50 |
| 4 | motor activity (GO:0003774) | 0.03252 | 0.04336 | 34.06 | 116.68 |
| 5 | microtubule binding (GO:0008017) | 0.005670 | 0.01512 | 21.48 | 111.10 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | endosome lumen (GO:0031904) | 2.326e-7 | 0.000006745 | 372.06 | 5682.76 |
| 2 | trans-Golgi network membrane (GO:0032588) | 0.00001377 | 0.0001996 | 88.81 | 994.11 |
| 3 | trans-Golgi network transport vesicle (GO:0030140) | 0.007476 | 0.03097 | 158.54 | 776.21 |
| 4 | endoplasmic reticulum tubular network (GO:0071782) | 0.01144 | 0.04148 | 100.85 | 450.83 |
| 5 | trans-Golgi network (GO:0005802) | 0.0001901 | 0.001837 | 35.87 | 307.37 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| SPG11 | – |
| REEP1 | – |
| RTN2 | – |
| SPG21 | – |
| KIAA0196 | – |
| NIPA1 | – |
| AP4E1 | – |
| AP4B1 | – |
| AP4S1 | – |
| KIF5A | – |
