Somatic sensory dysfunction (HP:0003474)
An abnormality of the primary sensation that is mediated by peripheral nerves (pain, temperature, touch, vibration, joint position). The word hypoesthesia (or hypesthesia) refers to a reduction in cutaneous sensation to a specific type of testing.
Synonyms: Sensory impairment
Comment: This term does not include abnormalities of cortical sensation such as two-point discrimination, stereognosis, and graphesthesia.
Cross References: MSH:D006987, SNOMEDCT_US:397974008, SNOMEDCT_US:398026008, SNOMEDCT_US:59073000, UMLS:C0020580
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Non-small cell lung cancer | 0.03543 | 0.1299 | 31.17 | 104.12 |
| 2 | Amyotrophic lateral sclerosis | 0.01350 | 0.1228 | 13.56 | 58.36 |
| 3 | Dopaminergic synapse | 0.06409 | 0.1570 | 16.84 | 46.28 |
| 4 | Cell adhesion molecules | 0.07160 | 0.1570 | 15.00 | 39.55 |
| 5 | Pathways of neurodegeneration | 0.02233 | 0.1228 | 10.32 | 39.22 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | synaptic vesicle transport (GO:0048489) | 0.00001235 | 0.0006828 | 555.03 | 6273.06 |
| 2 | synaptic vesicle localization (GO:0097479) | 0.00001750 | 0.0006828 | 454.07 | 4973.59 |
| 3 | endoplasmic reticulum tubular network organization (GO:0071786) | 0.00002354 | 0.0006828 | 384.17 | 4094.01 |
| 4 | anterograde dendritic transport (GO:0098937) | 0.002498 | 0.01672 | 555.17 | 3326.77 |
| 5 | anterograde dendritic transport of neurotransmitter receptor complex (GO:0098971) | 0.002498 | 0.01672 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | olfactory receptor binding (GO:0031849) | 0.002997 | 0.01299 | 444.11 | 2580.41 |
| 2 | microtubule binding (GO:0008017) | 0.0001741 | 0.002263 | 36.98 | 320.12 |
| 3 | alpha-tubulin binding (GO:0043014) | 0.01540 | 0.03443 | 73.93 | 308.54 |
| 4 | beta-tubulin binding (GO:0048487) | 0.01589 | 0.03443 | 71.54 | 296.32 |
| 5 | tubulin binding (GO:0015631) | 0.0003968 | 0.002579 | 27.75 | 217.37 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | endoplasmic reticulum tubular network membrane (GO:0098826) | 0.002498 | 0.01748 | 555.17 | 3326.77 |
| 2 | endoplasmic reticulum tubular network (GO:0071782) | 0.00005661 | 0.001585 | 237.73 | 2324.81 |
| 3 | Golgi cis cisterna (GO:0000137) | 0.01243 | 0.03868 | 92.44 | 405.55 |
| 4 | intrinsic component of endoplasmic reticulum membrane (GO:0031227) | 0.001583 | 0.01748 | 41.75 | 269.21 |
| 5 | integral component of endoplasmic reticulum membrane (GO:0030176) | 0.002170 | 0.01748 | 35.45 | 217.39 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| BSCL2 | – |
| REEP1 | – |
| KIF5A | – |
| SPG11 | – |
| NIPA1 | – |
| KIAA0196 | – |
| RTN2 | – |
| SPAST | – |
| ATL1 | – |
| MPZ | – |
