Long COVID – Skeletal muscle atrophy

Skeletal muscle atrophy (HP:0003202)

The presence of skeletal muscular atrophy (which is also known as amyotrophy).

Synonyms:    Muscle wasting, Muscle degeneration, Amyotrophy, Amyotrophy involving the extremities, Muscle atrophy, Muscle atrophy, neurogenic, Muscle hypotrophy, Muscular atrophy, Neurogenic muscle atrophy, Neurogenic muscle atrophy, especially in the lower limbs, Neurogenic muscular atrophy

Cross References:    MSH:D009133, SNOMEDCT_US:74035001, UMLS:C0234958, UMLS:C0270948, UMLS:C0541794, UMLS:C1843479

GO: Biological Process

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1cilium assembly (GO:0060271)5.098e-163.772e-14580.8720453.89
2pigment granule transport (GO:0051904)7.315e-89.022e-7570.719377.24
3melanosome transport (GO:0032402)7.315e-89.022e-7570.719377.24
4establishment of melanosome localization (GO:0032401)8.685e-89.181e-7535.028698.92
5melanosome localization (GO:0032400)1.191e-70.000001102475.527581.26

GO: Molecular Function

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1patched binding (GO:0005113)0.0034950.006990370.072093.27
2RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)1.780e-88.402e-8107.051910.30
3DNA-binding transcription factor binding (GO:0140297)2.801e-88.402e-897.471695.14
4phosphatidylinositol-3-phosphate binding (GO:0032266)0.019330.0290058.34230.20
5phosphatidylinositol phosphate binding (GO:1901981)0.049860.0598321.8865.61

GO: Cellular Component

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1motile cilium (GO:0031514)0.033490.0669833.04112.22
2neuron projection (GO:0043005)0.029940.066988.7730.77
3cilium (GO:0005929)0.11240.12769.3020.33
4cell-cell junction (GO:0005911)0.12760.12768.1216.71

Hub genes predicted as biomarkers & predicted FDA approved drugs

Hub Genes (ranked)FDA-Approved Drugs
BBS5–
BBS7–
BBS1–
LZTFL1–
BBS2–
BBS10–
WDPCP–
BBS12–
MKS1–
SDCCAG8–