Hyperkinetic movements (HP:0002487)
Motor hyperactivity with excessive movement of muscles of the body as a whole.
Synonyms: Muscle spasms, Hyperkinesia, Hyperkinesis
Cross References: MSH:D006948, MSH:D013035, SNOMEDCT_US:44548000, SNOMEDCT_US:45352006, UMLS:C0037763, UMLS:C0424295
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 8.806e-7 | 0.00001843 | 231.12 | 3222.36 |
| 2 | Dopaminergic synapse | 2.847e-9 | 1.281e-7 | 156.40 | 3077.49 |
| 3 | Cocaine addiction | 0.000001638 | 0.00001843 | 185.81 | 2475.38 |
| 4 | Butanoate metabolism | 0.00008446 | 0.0003801 | 191.96 | 1800.45 |
| 5 | Amphetamine addiction | 0.000004635 | 0.00004171 | 129.38 | 1588.99 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | gamma-aminobutyric acid metabolic process (GO:0009448) | 0.000002248 | 0.0001158 | 1665.58 | 21661.60 |
| 2 | excitatory chemical synaptic transmission (GO:0098976) | 0.000004719 | 0.0001215 | 999.25 | 12254.80 |
| 3 | response to ethanol (GO:0045471) | 0.00002354 | 0.0004042 | 384.17 | 4094.01 |
| 4 | glutamate catabolic process (GO:0006538) | 0.002498 | 0.008039 | 555.17 | 3326.77 |
| 5 | excitatory postsynaptic potential (GO:0060079) | 0.00003830 | 0.0005636 | 293.72 | 2987.15 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | glutamate-gated calcium ion channel activity (GO:0022849) | 0.000002248 | 0.00007644 | 1665.58 | 21661.60 |
| 2 | NMDA glutamate receptor activity (GO:0004972) | 0.000006290 | 0.00008213 | 832.67 | 9972.50 |
| 3 | ionotropic glutamate receptor activity (GO:0004970) | 0.00003048 | 0.0002072 | 332.92 | 3461.84 |
| 4 | opioid receptor binding (GO:0031628) | 0.002498 | 0.007077 | 555.17 | 3326.77 |
| 5 | ligand-gated calcium channel activity (GO:0099604) | 0.00003830 | 0.0002170 | 293.72 | 2987.15 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | NMDA selective glutamate receptor complex (GO:0017146) | 0.000006290 | 0.0001698 | 832.67 | 9972.50 |
| 2 | flotillin complex (GO:0016600) | 0.002498 | 0.008430 | 555.17 | 3326.77 |
| 3 | synaptic membrane (GO:0097060) | 0.00007266 | 0.0009809 | 207.98 | 1981.99 |
| 4 | clathrin-sculpted gamma-aminobutyric acid transport vesicle (GO:0061200) | 0.003994 | 0.009933 | 317.19 | 1751.86 |
| 5 | clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane (GO:0061202) | 0.003994 | 0.009933 | 317.19 | 1751.86 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| GRIN2A | MEMANTINE, GLYCINE, DEXTROMETHORPHAN POLISTIREX |
| GAD1 | METHADONE |
| CACNA1B | ZICONOTIDE, ZICONOTIDE ACETATE, AMLODIPINE, LEVETIRACETAM |
| GRIN1 | MEMANTINE, ORPHENADRINE |
| SCN1A | ETHOSUXIMIDE |
| GNAO1 | – |
| SLC6A3 | DEXMETHYLPHENIDATE, PHENMETRAZINE, MAZINDOL, DIETHYLPROPION, ARMODAFNIL, DEXTROAMPHETAMINE, PHENTERMINE, BUPROPION, MODAFINIL, LISDEXAMFETAMINE |
| IQSEC2 | – |
| ALDH5A1 | CHLORMERODRIN, VALPROATE SODIUM, DIVALPROEX SODIUM, VALPROIC ACID |
| PNKD | – |
