Abnormal reflex (HP:0031826)
Any anomaly of a reflex, i.e., of an automatic response mediated by the nervous system (a reflex does not need the intervention of conscious thought to occur).
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Phototransduction | 2.929e-7 | 0.000001758 | 342.26 | 5148.70 |
| 2 | Retinol metabolism | 0.03349 | 0.09654 | 33.04 | 112.22 |
| 3 | Purine metabolism | 0.06267 | 0.09654 | 17.24 | 47.76 |
| 4 | Spliceosome | 0.07253 | 0.09654 | 14.80 | 38.82 |
| 5 | cGMP-PKG signaling pathway | 0.08045 | 0.09654 | 13.27 | 33.44 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | rhodopsin mediated signaling pathway (GO:0016056) | 0.00001235 | 0.0001580 | 555.03 | 6273.06 |
| 2 | regulation of rhodopsin mediated signaling pathway (GO:0022400) | 2.058e-7 | 0.000004391 | 388.99 | 5988.96 |
| 3 | phototransduction, visible light (GO:0007603) | 0.00002354 | 0.0002511 | 384.17 | 4094.01 |
| 4 | visual perception (GO:0007601) | 9.004e-8 | 0.000003140 | 149.07 | 2418.38 |
| 5 | sensory perception of light stimulus (GO:0050953) | 9.813e-8 | 0.000003140 | 145.78 | 2352.45 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | guanylate cyclase activator activity (GO:0030250) | 0.002498 | 0.02195 | 555.17 | 3326.77 |
| 2 | NADP-retinol dehydrogenase activity (GO:0052650) | 0.002997 | 0.02195 | 444.11 | 2580.41 |
| 3 | intracellular cGMP-activated cation channel activity (GO:0005223) | 0.003495 | 0.02195 | 370.07 | 2093.27 |
| 4 | intracellular cAMP-activated cation channel activity (GO:0005222) | 0.004492 | 0.02195 | 277.53 | 1500.17 |
| 5 | leucine zipper domain binding (GO:0043522) | 0.004990 | 0.02195 | 246.68 | 1307.49 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | spliceosomal tri-snRNP complex (GO:0097526) | 0.01589 | 0.05160 | 71.54 | 296.32 |
| 2 | U4/U6 x U5 tri-snRNP complex (GO:0046540) | 0.01589 | 0.05160 | 71.54 | 296.32 |
| 3 | U2-type precatalytic spliceosome (GO:0071005) | 0.02473 | 0.05160 | 45.22 | 167.30 |
| 4 | precatalytic spliceosome (GO:0071011) | 0.02570 | 0.05160 | 43.44 | 159.04 |
| 5 | sperm flagellum (GO:0036126) | 0.02570 | 0.05160 | 43.44 | 159.04 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| RDH12 | – |
| NR2E3 | – |
| CRX | – |
| GUCA1B | – |
| PRPH2 | – |
| RPGR | – |
| TULP1 | – |
| PRPF3 | – |
| PDE6G | PENTOXIFYLLINE |
| CNGA1 | DEQUALINIUM |
