Expressive aphasia (HP:0002427)
Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it.
Synonyms: Non-fluent aphasia, Loss of expressive speech, Broca’s aphasia, Motor aphasia
Cross References: MSH:D001039, SNOMEDCT_US:229654003, SNOMEDCT_US:229665008, SNOMEDCT_US:328681008, UMLS:C0003550, UMLS:C0917814
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Osteoclast differentiation | 0.03135 | 0.1067 | 39.42 | 136.50 |
| 2 | mTOR signaling pathway | 0.03792 | 0.1067 | 32.42 | 106.10 |
| 3 | Parkinson disease | 0.06072 | 0.1067 | 19.91 | 55.77 |
| 4 | MAPK signaling pathway | 0.07138 | 0.1067 | 16.81 | 44.38 |
| 5 | Alzheimer disease | 0.08892 | 0.1067 | 13.33 | 32.27 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of hippocampal neuron apoptotic process (GO:0110089) | 0.001249 | 0.01102 | 1249.44 | 8352.53 |
| 2 | negative regulation of tubulin deacetylation (GO:1904428) | 0.001249 | 0.01102 | 1249.44 | 8352.53 |
| 3 | positive regulation of protein localization to synapse (GO:1902474) | 0.001249 | 0.01102 | 1249.44 | 8352.53 |
| 4 | chemokine (C-X-C motif) ligand 12 signaling pathway (GO:0038146) | 0.001249 | 0.01102 | 1249.44 | 8352.53 |
| 5 | regulation of inward rectifier potassium channel activity (GO:1901979) | 0.001249 | 0.01102 | 1249.44 | 8352.53 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | apolipoprotein A-I binding (GO:0034186) | 0.001249 | 0.01154 | 1249.44 | 8352.53 |
| 2 | lipoprotein particle binding (GO:0071813) | 0.00001377 | 0.0004544 | 605.24 | 6774.51 |
| 3 | sulfatide binding (GO:0120146) | 0.001499 | 0.01154 | 999.50 | 6499.56 |
| 4 | high-density lipoprotein particle binding (GO:0008035) | 0.001499 | 0.01154 | 999.50 | 6499.56 |
| 5 | minor groove of adenine-thymine-rich DNA binding (GO:0003680) | 0.001749 | 0.01154 | 832.88 | 5287.72 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | neurofibrillary tangle (GO:0097418) | 0.001249 | 0.01187 | 1249.44 | 8352.53 |
| 2 | glial cell projection (GO:0097386) | 0.003495 | 0.02214 | 384.27 | 2173.55 |
| 3 | connexin complex (GO:0005922) | 0.005239 | 0.02275 | 249.69 | 1311.24 |
| 4 | gap junction (GO:0005921) | 0.005986 | 0.02275 | 217.09 | 1111.12 |
| 5 | membrane raft (GO:0045121) | 0.0006496 | 0.01187 | 82.13 | 602.75 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| C9orf72 | – |
| MAPT | – |
| TREM2 | – |
| NPRL3 | – |
| GJB1 | CARBENOXOLONE |
