Migraine (HP:0002076)
Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.
Synonyms: Intermittent migraine headaches, Migraine, Migraine headache, Migraine headaches
Pubmed References: PMID:15304572
Cross References: MSH:D008881, SNOMEDCT_US:37796009, UMLS:C0149931, UMLS:C0744641
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Prolactin signaling pathway | 2.843e-8 | 0.000001801 | 201.25 | 3496.91 |
| 2 | Chronic myeloid leukemia | 3.973e-8 | 0.000001801 | 184.43 | 3142.85 |
| 3 | Pancreatic cancer | 3.973e-8 | 0.000001801 | 184.43 | 3142.85 |
| 4 | AGE-RAGE signaling pathway in diabetic complications | 1.207e-7 | 0.000002998 | 138.15 | 2200.74 |
| 5 | Thyroid hormone signaling pathway | 2.602e-7 | 0.000005539 | 113.24 | 1716.86 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | detection of stimulus involved in sensory perception of pain (GO:0062149) | 0.000004719 | 0.001949 | 999.25 | 12254.80 |
| 2 | detection of mechanical stimulus involved in sensory perception (GO:0050974) | 0.00002354 | 0.004270 | 384.17 | 4094.01 |
| 3 | positive regulation of cell proliferation involved in heart morphogenesis (GO:2000138) | 0.002498 | 0.02406 | 555.17 | 3326.77 |
| 4 | positive regulation of histone H3-K9 acetylation (GO:2000617) | 0.002498 | 0.02406 | 555.17 | 3326.77 |
| 5 | cardiac endothelial cell differentiation (GO:0003348) | 0.002498 | 0.02406 | 555.17 | 3326.77 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | transcription coactivator binding (GO:0001223) | 1.021e-7 | 0.000007457 | 503.52 | 8105.11 |
| 2 | RNA polymerase II general transcription initiation factor binding (GO:0001091) | 0.002498 | 0.02602 | 555.17 | 3326.77 |
| 3 | glutamate-gated calcium ion channel activity (GO:0022849) | 0.002498 | 0.02602 | 555.17 | 3326.77 |
| 4 | transcription coregulator binding (GO:0001221) | 0.000002081 | 0.00007596 | 170.91 | 2236.02 |
| 5 | 1-phosphatidylinositol-4-phosphate 3-kinase activity (GO:0035005) | 0.003495 | 0.02602 | 370.07 | 2093.27 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | phosphatidylinositol 3-kinase complex, class I (GO:0097651) | 0.002498 | 0.03039 | 555.17 | 3326.77 |
| 2 | NMDA selective glutamate receptor complex (GO:0017146) | 0.003994 | 0.03039 | 317.19 | 1751.86 |
| 3 | voltage-gated sodium channel complex (GO:0001518) | 0.008469 | 0.03949 | 138.71 | 661.82 |
| 4 | postsynaptic density membrane (GO:0098839) | 0.009957 | 0.03949 | 116.79 | 538.34 |
| 5 | postsynaptic specialization membrane (GO:0099634) | 0.01045 | 0.03949 | 110.94 | 506.01 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| KRAS | PANITUMUMAB, CETUXIMAB |
| PIK3CA | – |
| ESR1 | CLOMIPHENE, LEVONORGESTREL |
| SMAD4 | LYSINE, ALECTINIB |
| NF1 | TRAMETINIB, BINIMETINIB, COBIMETINIB, DABRAFENIB, VEMURAFENIB |
| NOTCH3 | – |
| RELA | – |
| SCN1A | ETHOSUXIMIDE |
| GRIN2A | MEMANTINE, GLYCINE, DEXTROMETHORPHAN POLISTIREX |
| KCNA1 | BUPIVACAINE, ISOFLURANE, DESFLURANE |
