Long COVID – Abnormal fear/anxiety-related behavior

Abnormal fear/anxiety-related behavior (HP:0100852)

An abnormality of fear/anxiety-related behavior, which may relate to either abnormally reduced fear/anxiety-related response or increased fear/anxiety-related response.

Synonyms:    Abnormal fear/anxiety-related behaviour

Cross References:    UMLS:C4018849

GO: Biological Process

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1equilibrioception (GO:0050957)5.668e-173.287e-1519989.00747771.16
2neuromuscular process controlling balance (GO:0050885)1.888e-142.738e-132220.1170156.55
3sensory perception (GO:0007600)4.223e-144.899e-13664.8320473.93
4sensory perception of mechanical stimulus (GO:0050954)2.969e-157.316e-14573.5119184.17
5sensory perception of sound (GO:0007605)3.784e-157.316e-14552.9418362.12

GO: Molecular Function

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1myosin binding (GO:0017022)0.027660.0553140.27144.50
2calcium ion binding (GO:0005509)0.012390.0553114.1962.33
3magnesium ion binding (GO:0000287)0.070660.106015.2140.30
4metal ion binding (GO:0046872)0.026160.055319.4534.45
5cadherin binding (GO:0045296)0.14990.17986.8112.92

GO: Cellular Component

IndexNameP-valueAdjusted p-valueOdds RatioCombined score
1microvillus (GO:0005902)0.00035390.00389390.61720.07
2actin-based cell projection (GO:0098858)0.00074930.00412161.45442.20
3catenin complex (GO:0016342)0.015400.0564573.93308.54
4basement membrane (GO:0005604)0.025700.0706843.44159.04
5cilium (GO:0005929)0.11240.24739.3020.33

Hub genes predicted as biomarkers & predicted FDA approved drugs

Hub Genes (ranked)FDA-Approved Drugs
GPR98–
USH1C–
CLRN1–
PDZD7–
USH2A–
USH1G–
PCDH15–
DFNB31–
CIB2–
CDH23METHYLPHENIDATE