Abnormal emotion/affect behavior (HP:0100851)
An abnormality of emotional behaviour.
Synonyms: Abnormal emotion/affect behaviour
Cross References: UMLS:C4020949
KEGG Pathway
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | Nicotine addiction | 5.437e-21 | 2.882e-19 | 2494.75 | 116407.64 |
| 2 | Amphetamine addiction | 5.059e-16 | 1.341e-14 | 749.98 | 26414.43 |
| 3 | Circadian entrainment | 6.002e-15 | 1.060e-13 | 515.93 | 16894.89 |
| 4 | Long-term potentiation | 9.011e-11 | 5.970e-10 | 321.42 | 7434.41 |
| 5 | Glutamatergic synapse | 6.187e-12 | 5.466e-11 | 276.14 | 7126.73 |
GO: Biological Process
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | regulation of NMDA receptor activity (GO:2000310) | 1.586e-18 | 1.950e-16 | 1863.40 | 76372.57 |
| 2 | excitatory chemical synaptic transmission (GO:0098976) | 3.147e-9 | 4.838e-8 | 2141.36 | 41921.23 |
| 3 | regulation of neurotransmitter receptor activity (GO:0099601) | 1.412e-16 | 5.788e-15 | 912.24 | 33293.64 |
| 4 | glutamate receptor signaling pathway (GO:0007215) | 5.464e-15 | 1.120e-13 | 965.76 | 31715.99 |
| 5 | anterograde trans-synaptic signaling (GO:0098916) | 5.108e-17 | 3.142e-15 | 756.57 | 28381.44 |
GO: Molecular Function
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | ionotropic glutamate receptor activity (GO:0004970) | 2.918e-17 | 1.430e-15 | 2724.41 | 103726.10 |
| 2 | glutamate-gated calcium ion channel activity (GO:0022849) | 8.995e-10 | 6.296e-9 | 4283.14 | 89214.48 |
| 3 | ligand-gated channel activity (GO:0022834) | 1.397e-15 | 2.830e-14 | 1247.88 | 42682.61 |
| 4 | ligand-gated ion channel activity (GO:0015276) | 1.732e-15 | 2.830e-14 | 1197.90 | 40715.77 |
| 5 | NMDA glutamate receptor activity (GO:0004972) | 5.033e-9 | 2.740e-8 | 1713.00 | 32730.63 |
GO: Cellular Component
| Index | Name | P-value | Adjusted p-value | Odds Ratio | Combined score |
| 1 | ionotropic glutamate receptor complex (GO:0008328) | 2.132e-15 | 6.395e-14 | 1151.77 | 38908.86 |
| 2 | NMDA selective glutamate receptor complex (GO:0017146) | 5.033e-9 | 3.775e-8 | 1713.00 | 32730.63 |
| 3 | cation channel complex (GO:0034703) | 3.977e-13 | 5.966e-12 | 446.04 | 12735.72 |
| 4 | AMPA glutamate receptor complex (GO:0032281) | 1.021e-7 | 6.129e-7 | 503.52 | 8105.11 |
| 5 | synaptic membrane (GO:0097060) | 2.326e-7 | 0.000001163 | 372.06 | 5682.76 |
Hub genes predicted as biomarkers & predicted FDA approved drugs
| Hub Genes (ranked) | FDA-Approved Drugs |
| GRIA2 | PERAMPANEL |
| SLC6A1 | TIAGABINE, TIAGABINE HYDROCHLORIDE |
| GRIN2A | MEMANTINE, GLYCINE, DEXTROMETHORPHAN POLISTIREX |
| GRIN1 | MEMANTINE, ORPHENADRINE |
| GRIA3 | PERAMPANEL |
| CAMK2A | – |
| GABRG2 | – |
| GABRA1 | METHOHEXITAL, BARBITAL, THIAMYLAL, ZALEPLON, ZOPICLONE, ZOLPIDEM |
| GRIA4 | PERAMPANEL, PIRACETAM |
| GRIN2B | MEMANTINE, FELBAMATE, ACAMPROSATE |
